L1CAM_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: L1CAM_RAT
• UniProt AC: Q05695
• Protein Name: Neural cell adhesion molecule L1
• Gene Name: L1cam
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1259
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Cell projection, growth cone . Colocalized with SHTN1 in close apposition with actin filaments in filopodia and lamellipodia of axonal growth cones of hippocampal neurons (PubMed:18519736).
• Protein Description: Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity..
• Protein Sequence: MVMMLWYVLPLLLCSPCLLIQIPDEYKGHHVLEPPVITEQSPRRLVVFPTDDISLKCEARGRPQVEFRWTKDGIHFKPKEELGVVVHEAPYSGSFTIEGNNSFAQRFQGIYRCYASNNLGTAMSHEIQLVAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAAPLRIYWMNSKILHIKQDERVSMGQNGDLYFANVLTSDNHSDYICNAHFPGTRTIIQKEPIDLRVKPTNSMIDRKPRLLFPTNSSSHLVALQGQSLILECIAEGFPTPTIKWLHPSDPMPTDRVIYQNHNKTLQLLNVGEEDDGEYTCLAENSLGSARHAYYVTVEAAPYWLQKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGMSIEKVNKDQKYRIEQGSLILSNVQPSDTMVTQCEARNQHGLLLANAYIYVVQLPARILTKDNQTYMAVEGSTAYLLCKAFGAPVPSVQWLDEEGTTVLQDERFFPYANGHLGIRDLQANDTGRYFCQAANDQNNVTILANLQVKEATQITQGPRSTIEKKGARVTFTCQASFDPSLQASITWRGDGRDLQERGDSDKYFIEDGQLVIKSLDYSDQGDYSCVASTELDEVESRAQLLVVGSPGPVPHLELSDRHLLKQSQVHLSWSPAEDHNSPIEKYDIEFEDKEMAPEKWFSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVRGEGNETNNMVITWKPLRWMDWNAPQIQYRVQWRPLGKQETWKEQTVSDPFLVVSNTSTFVPYEIKVQAVNNQGKGPEPQVTIGYSGEDYPQVSPELEDITIFNSSTVLVRWRPVDLAQVKGHLRGYNVTYWWKGSQRKHSKRHVHKSHMVVPANTTSAILSGLRPYSSYHVEVQAFNGRGLGPASEWTFSTPEGVPGHPEALHLECQSDTSLLLHWQPPLSHNGVLTGYLLSYHPLDGESKEQLFFNLSDPELRTHNLTNLNPDLQYRFQLQATTHQGPGEAIVREGGTMALFGKPDFGNISVTAGENYSVVSWVPREGQCNFRFHILFKALPEGKVSPDHQPQPQYVSYNQSSYTQWDLQPDTKYEIHLMREKVLLHHLAVKTNGTGPVRVSTTGSFASEGWFIAFVSAIILLLLILLILCFIKRSKGGKYSVKDKEDTQVDSEARPMKDETFGEYRSLESDNEEKAFGSSQPSLNGDIKPLGSDDSLADYGGSVDVQFNEDGSFIGQYSGKKEKEAAGGNDSSGATSPINPAVALE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
100	N-linked_Glycosylation	GSFTIEGNNSFAQRF CCEEEECCCHHHHHH	28.34	-
202	N-linked_Glycosylation	ANVLTSDNHSDYICN EEEECCCCCCCCEEC	36.01	24090084
246	N-linked_Glycosylation	PRLLFPTNSSSHLVA CCEECCCCCCCCEEE	39.88	-
293	N-linked_Glycosylation	RVIYQNHNKTLQLLN CEEEECCCCEEEECC	46.70	-
432	N-linked_Glycosylation	ARILTKDNQTYMAVE CEEECCCCCEEEEEC	37.34	-
489	N-linked_Glycosylation	GIRDLQANDTGRYFC EECCCCCCCCCCEEE	34.12	-
504	N-linked_Glycosylation	QAANDQNNVTILANL ECCCCCCCEEEEEEE	27.03	-
670	N-linked_Glycosylation	SLGKVPGNQTSTTLK ECCCCCCCCCCCEEE	35.57	24090084
725	N-linked_Glycosylation	VDVRGEGNETNNMVI CCCCCCCCCCCCEEE	48.92	24090084
776	N-linked_Glycosylation	DPFLVVSNTSTFVPY CCEEEEECCCCEECE	26.83	-
824	N-linked_Glycosylation	LEDITIFNSSTVLVR CEEEEEECCCCEEEE	31.06	-
848	N-linked_Glycosylation	KGHLRGYNVTYWWKG CCHHCCCEEEEEECC	23.60	-
875	N-linked_Glycosylation	SHMVVPANTTSAILS CCEEECCCCHHHHHH	37.51	-
968	N-linked_Glycosylation	SKEQLFFNLSDPELR CHHHEEEECCCHHHH	31.16	-
978	N-linked_Glycosylation	DPELRTHNLTNLNPD CHHHHHCCCCCCCCC	48.20	24090084
1021	N-linked_Glycosylation	FGKPDFGNISVTAGE ECCCCCCCEEEECCC	24.29	-
1029	N-linked_Glycosylation	ISVTAGENYSVVSWV EEEECCCCEEEEEEC	33.20	-
1072	N-linked_Glycosylation	QPQYVSYNQSSYTQW CCCEEECCCCCCCCC	27.96	24090084
1106	N-linked_Glycosylation	HHLAVKTNGTGPVRV EEEEECCCCCCCEEE	40.07	-
1153	Phosphorylation	KRSKGGKYSVKDKED HHHCCCCCCCCCCCC	23.21	18478542
1154	Phosphorylation	RSKGGKYSVKDKEDT HHCCCCCCCCCCCCC	26.61	8663493
1161	Phosphorylation	SVKDKEDTQVDSEAR CCCCCCCCCCCCCCC	31.42	30240740
1165	Phosphorylation	KEDTQVDSEARPMKD CCCCCCCCCCCCCCC	34.01	30240740
1174	Phosphorylation	ARPMKDETFGEYRSL CCCCCCCCCCCEECC	47.26	28551015
1178 (in isoform 2)	Phosphorylation	-	13.09	22108457
1178	Phosphorylation	KDETFGEYRSLESDN CCCCCCCEECCCCCC	13.09	15911348
1179 (in isoform 2)	Phosphorylation	-	30.39	22108457
1180	Phosphorylation	ETFGEYRSLESDNEE CCCCCEECCCCCCHH	35.27	30240740
1183	Phosphorylation	GEYRSLESDNEEKAF CCEECCCCCCHHHHH	51.54	8592152
1192	Phosphorylation	NEEKAFGSSQPSLNG CHHHHHCCCCCCCCC	21.24	22673903
1193	Phosphorylation	EEKAFGSSQPSLNGD HHHHHCCCCCCCCCC	46.63	22673903
1196	Phosphorylation	AFGSSQPSLNGDIKP HHCCCCCCCCCCCCC	27.16	22673903
1206	Phosphorylation	GDIKPLGSDDSLADY CCCCCCCCCCCHHHC	46.02	22673903
1209	Phosphorylation	KPLGSDDSLADYGGS CCCCCCCCHHHCCCE	30.37	22673903
1213	Phosphorylation	SDDSLADYGGSVDVQ CCCCHHHCCCEEEEE	20.13	22673903
1216	Phosphorylation	SLADYGGSVDVQFNE CHHHCCCEEEEEECC	15.69	22673903
1226	Phosphorylation	VQFNEDGSFIGQYSG EEECCCCCCEEEECC	26.47	22673903
1231	Phosphorylation	DGSFIGQYSGKKEKE CCCCEEEECCCCCCC	17.74	22673903
1232	Phosphorylation	GSFIGQYSGKKEKEA CCCEEEECCCCCCCC	35.93	22673903
1245	Phosphorylation	EAAGGNDSSGATSPI CCCCCCCCCCCCCCC	34.37	22108457
1246	Phosphorylation	AAGGNDSSGATSPIN CCCCCCCCCCCCCCC	35.00	30240740
1249	Phosphorylation	GNDSSGATSPINPAV CCCCCCCCCCCCHHH	38.26	22108457
1250	Phosphorylation	NDSSGATSPINPAVA CCCCCCCCCCCHHHC	24.21	22108457

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1148	S	Phosphorylation	Kinase	RPS6KA2	F1M7N7	GPS
1153	Y	Phosphorylation	Kinase	SRC	P05480	PSP
1154	S	Phosphorylation	Kinase	RPS6KA1	Q63531	GPS
1183	S	Phosphorylation	Kinase	CSNK2A1	P19139	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of L1CAM_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of L1CAM_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.