EME1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EME1_MOUSE
• UniProt AC: Q8BJW7
• Protein Name: Crossover junction endonuclease EME1
• Gene Name: Eme1
• Organism: Mus musculus (Mouse).
• Sequence Length: 570
• Subcellular Localization: Nucleus, nucleolus. Recruited to regions of DNA damage in S-phase cells..
• Protein Description: Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks..
• Protein Sequence: MALRRLSLSRLSTESDSEDLPTFAFLKKEPSSTNRKPPQRAKNIVVVTSDSEASCPPSPGLKGPPCVPSAAGAPPQAGPVRVLSSSSEDEDVFVPLAERITCKLLTSKQLCPELSSSSLKTGLDGQNNASAPCDWKRQPWPKIPDVPLHGALEKSAANDEDSLLDDQCRQLPTYQATCRELAVSKTNSDRPLPKKRTKHIQTVQSGGSQGCWRPGQASRKENTPRQHERKKKAEMIKRLKAQRPEECLKHIVVVLDPVLLQMEGGGQLLGALQAMECSCVIEVQAIPRSITWRRRRTELVEDGDDWMEEPTILVLVLAEVFMSMAYNLKQASPSSTEKGKETLRSFVTDVTAKTGKALSLVIVDQEKCFRPQNPPRRRKSGMANKQAKAKHQQRQESSTGLMVSRADMEKALVDLQLYTEAQAWMVQSWKELADFTCAFTKAVAEAPFKKLRDQVTFSFFLEKDWAGGMKVDQSGRGLALIWRRQIQQLNRVSSEMASAIVDAYPSPQLLVQAYQRCFSEQERQNLLADIQVRRGEGVTATSRRVGPELSRRIYLQMTTAQPDLILDSVD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MALRRLSLSRLSTE -CCHHHHHHHHCCCC	23.61	26643407
9	Phosphorylation	ALRRLSLSRLSTESD CHHHHHHHHCCCCCC	28.00	26643407
12	Phosphorylation	RLSLSRLSTESDSED HHHHHHCCCCCCCCC	29.08	21149613
13	Phosphorylation	LSLSRLSTESDSEDL HHHHHCCCCCCCCCC	44.06	23984901
15	Phosphorylation	LSRLSTESDSEDLPT HHHCCCCCCCCCCCC	46.67	21082442
17	Phosphorylation	RLSTESDSEDLPTFA HCCCCCCCCCCCCEE	42.14	21149613
48	Phosphorylation	AKNIVVVTSDSEASC CCCEEEEECCCCCCC	18.40	26643407
49	Phosphorylation	KNIVVVTSDSEASCP CCEEEEECCCCCCCC	27.77	26643407
51	Phosphorylation	IVVVTSDSEASCPPS EEEEECCCCCCCCCC	34.53	26643407
54	Phosphorylation	VTSDSEASCPPSPGL EECCCCCCCCCCCCC	24.09	28066266
58	Phosphorylation	SEASCPPSPGLKGPP CCCCCCCCCCCCCCC	19.42	28066266
84	Phosphorylation	AGPVRVLSSSSEDED CCCEEEECCCCCCCC	25.89	22817900
85	Phosphorylation	GPVRVLSSSSEDEDV CCEEEECCCCCCCCC	33.45	22817900
86	Phosphorylation	PVRVLSSSSEDEDVF CEEEECCCCCCCCCH	34.08	22817900
87	Phosphorylation	VRVLSSSSEDEDVFV EEEECCCCCCCCCHH	51.52	22817900
117	Phosphorylation	LCPELSSSSLKTGLD CCHHHCCCCCCCCCC	35.99	-
162	Phosphorylation	SAANDEDSLLDDQCR HHCCCCCCCCHHHHH	28.87	22006019
332	Phosphorylation	AYNLKQASPSSTEKG HHHCHHCCCCCCHHH	23.87	27841257
354	Phosphorylation	VTDVTAKTGKALSLV HHHHHHCCCCEEEEE	41.26	28576409
398	Phosphorylation	HQQRQESSTGLMVSR HHHHHHHHHCCEEEH	26.24	22871156
404	Phosphorylation	SSTGLMVSRADMEKA HHHCCEEEHHHHHHH	14.05	22871156

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EME1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EME1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EME1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UHRF1_MOUSE	Uhrf1	physical	18692478
MUS81_MOUSE	Mus81	physical	18692478

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.