ELOV3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ELOV3_HUMAN
• UniProt AC: Q9HB03
• Protein Name: Elongation of very long chain fatty acids protein 3 {ECO:0000255|HAMAP-Rule:MF_03203, ECO:0000305}
• Gene Name: ELOVL3 {ECO:0000255|HAMAP-Rule:MF_03203}
• Organism: Homo sapiens (Human).
• Sequence Length: 270
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators..
• Protein Sequence: MVTAMNVSHEVNQLFQPYNFELSKDMRPFFEEYWATSFPIALIYLVLIAVGQNYMKERKGFNLQGPLILWSFCLAIFSILGAVRMWGIMGTVLLTGGLKQTVCFINFIDNSTVKFWSWVFLLSKVIELGDTAFIILRKRPLIFIHWYHHSTVLVYTSFGYKNKVPAGGWFVTMNFGVHAIMYTYYTLKAANVKPPKMLPMLITSLQILQMFVGAIVSILTYIWRQDQGCHTTMEHLFWSFILYMTYFILFAHFFCQTYIRPKVKAKTKSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	N-linked_Glycosylation	--MVTAMNVSHEVNQ --CCCCCCCCHHHHH	29.67	-
110	N-linked_Glycosylation	CFINFIDNSTVKFWS EEEEEECCCHHHHHH	34.46	UniProtKB CARBOHYD
131	Phosphorylation	KVIELGDTAFIILRK HHHHHCCEEEEEEEC	22.97	24719451
203	Phosphorylation	KMLPMLITSLQILQM CHHHHHHHHHHHHHH	21.30	-
204	Phosphorylation	MLPMLITSLQILQMF HHHHHHHHHHHHHHH	15.98	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ELOV3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ELOV3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ELOV3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MUC20_HUMAN	MUC20	physical	21988832

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.