dbPTM

EKI2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	EKI2_HUMAN
UniProt AC	Q9NVF9
Protein Name	Ethanolamine kinase 2
Gene Name	ETNK2
Organism	Homo sapiens (Human).
Sequence Length	386
Subcellular Localization
Protein Description	Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity)..
Protein Sequence	MAVPPSAPQPRASFHLRRHTPCPQCSWGMEEKAAASASCREPPGPPRAAAVAYFGISVDPDDILPGALRLIQELRPHWKPEQVRTKRFTDGITNKLVACYVEEDMQDCVLVRVYGERTELLVDRENEVRNFQLLRAHSCAPKLYCTFQNGLCYEYMQGVALEPEHIREPRLFRLIALEMAKIHTIHANGSLPKPILWHKMHNYFTLVKNEINPSLSADVPKVEVLERELAWLKEHLSQLESPVVFCHNDLLCKNIIYDSIKGHVRFIDYEYAGYNYQAFDIGNHFNEFAGVNEVDYCLYPARETQLQWLHYYLQAQKGMAVTPREVQRLYVQVNKFALASHFFWALWALIQNQYSTIDFDFLRYAVIRFNQYFKVKPQASALEMPK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MAVPPSAPQPRAS --CCCCCCCCCCCCE	46.65	-
13	Phosphorylation	SAPQPRASFHLRRHT CCCCCCCEEECCCCC	17.93	24719451
93	Phosphorylation	KRFTDGITNKLVACY CCCCCCCCCCEEEEE	31.65	-
190	Phosphorylation	HTIHANGSLPKPILW CEECCCCCCCCCCCH	41.11	24719451
322	Phosphorylation	AQKGMAVTPREVQRL HCCCCCCCHHHHHHH	13.69	24719451
330	Phosphorylation	PREVQRLYVQVNKFA HHHHHHHHHHHHHHH	7.33	20049867
380	Phosphorylation	FKVKPQASALEMPK- EEECCCCCHHCCCC-	28.30	30622161

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of EKI2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of EKI2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of EKI2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MDFI_HUMAN	MDFI	physical	19060904
NPL4_HUMAN	NPLOC4	physical	26186194
RB11B_HUMAN	RAB11B	physical	26186194
RB11B_HUMAN	RAB11B	physical	28514442

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of EKI2_HUMAN

Related Literatures of Post-Translational Modification