EIF3B_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EIF3B_ARATH
• UniProt AC: Q9C5Z1
• Protein Name: Eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001}
• Gene Name: TIF3B1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 712
• Subcellular Localization: Cytoplasm .
• Protein Description: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation..
• Protein Sequence: MEVVDIDARAAKLGIDWSQVNFDSIQLPPGEDFGIESDDEAVYQDDQSEFDTGFGNIIVVDHLPVVPKEKFEKLEGVVKKIYNQLGVIKENGLWMPVDPDTKMTLGYCFIEFNTPQEAQNAKEKSHGYKLDKSHIFAVNMFDDFDRLMNVKEEWEPPQARPYVPGENLQKWLTDEKARDQLVIRSGPDTEVFWNDTRQKAPEPVHKRPYWTESYVQWSPLGTYLVTLHKQGAAVWGGADTFTRLMRYQHSMVKLVDFSPGEKYLVTYHSQEPSNPRDASKVEIKVFDVRTGRMMRDFKGSADEFSIGGPGGVAGASWPVFRWAGGKDDKYFAKLSKNTISVYETETFSLIDKKSMKVDNVVDICWSPTDSILSLFVPEQGGGNQPAKVALVQIPSKVELRQKNLFSVSDCKMYWQSSGEYLAVKVDRYTKTKKSTYSGFELFRIKERDIPIEVLELDNKNDKIIAFAWEPKGHRFAVIHGDQPRPDVSFYSMKTAQNTGRVSKLATLKAKQANALFWSPTGKYIILAGLKGFNGQLEFFNVDELETMATAEHFMATDIEWDPTGRYVATAVTSVHEMENGFTIWSFNGIMLYRILKDHFFQLAWRPRPPSFLTAEKEEEIAKTLKKYSKKYEAEDQDVSLLLSEQDREKRKALKEEWEKWVMQWKSLHEEEKLVRQNLRDGEVSDVEEDEYEAKEVEFEDLIDVTEEIVQES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEVVDIDA -------CCEEEHHH	8.77	22223895
273	Phosphorylation	TYHSQEPSNPRDASK EEECCCCCCCCCCCC	59.73	30407730
684	Phosphorylation	NLRDGEVSDVEEDEY HCCCCCCCCCCCCCE	31.47	30291188
691	Phosphorylation	SDVEEDEYEAKEVEF CCCCCCCEEEEEECH	33.24	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EIF3B_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EIF3B_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EIF3B_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EIF3H_ARATH	TIF3H1	physical	15548739
EIF3C_ARATH	EIF3C	physical	11029466
CSN7_ARATH	FUS5	physical	11029466

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteomic analysis of nuclei-enriched fractions fromArabidopsis thaliana.";
Jones A.M.E., MacLean D., Studholme D.J., Serna-Sanz A.,Andreasson E., Rathjen J.P., Peck S.C.;
J. Proteomics 72:439-451(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-684, AND MASSSPECTROMETRY.
PubMed: 19245862