dbPTM

EI2BG_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	EI2BG_SCHPO
UniProt AC	P56288
Protein Name	Probable translation initiation factor eIF-2B subunit gamma
Gene Name	tif223
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	458
Subcellular Localization	Cytoplasm .
Protein Description	Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP..
Protein Sequence	MSLYEHAALPLASSPSILGPISGGRNRGNIQLQSIPIEFQAVVFAGFGNSLYPLTGSDALPKALLPIGNKPMLHYPLYWLEAAGFTSAILICMEEAEAHINAWLRSGYEGHMRIHVEAPTILDDSKSSADALRAVSHLIKNDFVCLSCDSIVGLPPIYGLDKFRLDNPSALAVYSPVLKYEHITSQSKEIDAKQLIGIEEKTSRLLYAKSSADVGSDFTFRMSLLWKHPRVTLNTNLSDAHIFVFKHWVIDLIREKESISSIRGDLIPYLVKCQYQKSFTVRENIQRFLSSPNNIDNYDGGLSSQEIKINALIAKDGIICSRANNLPNYFELNKCIAKLTPEQRLVDVTVSERALVGADCMVNEGTTIKDNSNIKKSIIGKNCVIGKGVVVSNSILMDNIVVEDGVRLESCIVASGAQIGAKSKLRECEIGVDHRVEAGRIARGERLVDMEKIETDMD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLYEHAAL ------CCHHHCCCC	39.39	29996109
13	Phosphorylation	HAALPLASSPSILGP CCCCCCCCCCCEECC	50.92	29996109
14	Phosphorylation	AALPLASSPSILGPI CCCCCCCCCCEECCC	19.63	29996109
210	Phosphorylation	SRLLYAKSSADVGSD HHEEEEHHCCCCCCC	23.68	25720772
211	Phosphorylation	RLLYAKSSADVGSDF HEEEEHHCCCCCCCC	27.99	25720772
290	Phosphorylation	ENIQRFLSSPNNIDN HHHHHHHHCCCCCCC	40.83	29996109
291	Phosphorylation	NIQRFLSSPNNIDNY HHHHHHHCCCCCCCC	33.52	25720772
455	Phosphorylation	VDMEKIETDMD---- ECHHHHCCCCC----	39.85	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of EI2BG_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of EI2BG_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of EI2BG_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
EI2BG_SCHPO	tif223	physical	26771498
EI2BE_SCHPO	tif225	physical	26771498

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of EI2BG_SCHPO

Related Literatures of Post-Translational Modification