dbPTM

EI2BD_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	EI2BD_SCHPO
UniProt AC	Q09924
Protein Name	Probable translation initiation factor eIF-2B subunit delta
Gene Name	tif224
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	467
Subcellular Localization
Protein Description	Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP..
Protein Sequence	MGFSAEQAKKDGKDQSPVSESSSVGGTSPATASSVVSPNEPKLSGKEAKALKKARKQASRRAKAEAAAANNPPGVSEEKKVAIPNKNSNQQKKASKQNPQNSPETDANLQEKKIFEEKQVSIFSHLDWRRRRTTENIPKDIHPAVIRLGLKLANYKIFGSNQRCIDLLKTFKIVIQDYQTPYGTTLSRHLTTHINSQIAYLVSTRPLSISMGNAIRFLKLEISVLDIDLTDDEGKELLLEKIDSYIRDRIIIAGQVIVQAATEKIQDGDVILTYLHSSTVNDVLIHAKNVGKKFRVVVVDSRPEFEGRVCLKLLTEHGIECTYVMISALSYIMQEVTKIFLGGHAMLSNGALYSRAGTSLISLLGHESNVPVIACCESYKFTERIQLDSLVYNELAPGDQLVNMGVDDFEEKPGVLANWKSVKNLKLLSLKYDVTPPRLITVCVCEMGLLPSTSVPAIINEFKQVYA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	KKDGKDQSPVSESSS HHCCCCCCCCCCCCC	37.09	28889911
19	Phosphorylation	GKDQSPVSESSSVGG CCCCCCCCCCCCCCC	34.83	28889911
21	Phosphorylation	DQSPVSESSSVGGTS CCCCCCCCCCCCCCC	22.02	28889911
23	Phosphorylation	SPVSESSSVGGTSPA CCCCCCCCCCCCCCC	33.78	28889911
27	Phosphorylation	ESSSVGGTSPATASS CCCCCCCCCCCCHHH	26.13	28889911
28	Phosphorylation	SSSVGGTSPATASSV CCCCCCCCCCCHHHC	18.80	28889911
31	Phosphorylation	VGGTSPATASSVVSP CCCCCCCCHHHCCCC	30.38	29996109
37	Phosphorylation	ATASSVVSPNEPKLS CCHHHCCCCCCCCCC	21.61	28889911
102	Phosphorylation	SKQNPQNSPETDANL HHCCCCCCHHCCHHH	20.90	28889911
105	Phosphorylation	NPQNSPETDANLQEK CCCCCHHCCHHHHHH	43.74	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of EI2BD_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of EI2BD_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of EI2BD_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
EI2BB_SCHPO	SPAC343.14c	physical	26771498

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of EI2BD_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16; SER-19; SER-21;SER-23; THR-27; SER-28 AND SER-37, AND MASS SPECTROMETRY.	18257517 [Abstract]