EH1L1_MOUSE - dbPTM
EH1L1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EH1L1_MOUSE
UniProt AC Q99MS7
Protein Name EH domain-binding protein 1-like protein 1
Gene Name Ehbp1l1
Organism Mus musculus (Mouse).
Sequence Length 1716
Subcellular Localization Endosome . Recycling endosome .
Protein Description May act as Rab effector protein and play a role in vesicle trafficking (By similarity). Involved in apical-directed transport in polarized epithelial cells; the functions seems to implicate Rab8, BIN1 and possibly DNM1. [PubMed: 26833786]
Protein Sequence MTSVWKRLQRVGKRAAKFQFVACYHELVLECTKKWQPDKLVVVWTRRNRRICSKAHSWQPGIQNPYRGTVVWMVPENVDISVTLYRDPHVDQYETKEWTFIIENESKGQRKVLATVDVNLAHHAGPVPAQVPLRLRLKPKSVKVVHAELSLTLSGVLLREGRATDDDMQSLASLMSVKPSDVGNLDDFAESDEEEANGPGAPEVRTRGPQSDLSRELKTLCEEEDEGHIRPQQAAARPSSAEDTSPAPVSAPAPPVRAFRGQGSEPAAITGGQVGPETPEPPPSPPETRSTGQPGQTMVPTPAPRLRKGSDAPSSPVPCSGDEVPNTSEDPPTGMGSSGETQAQISSQEGTEAHEARPEPDIEVRGSKDSLGGERSKVEEEERGDGPGASGTGNREKNTKKSDTTAGEAGESSELHQVDAEHKSKVQHRATEGPEAAGLTPKARLGDTPEAPPRSAQRRMGVRTQEEAPSDLNPPPAEPEEHLGDLRDARPAGQEKGSAEVRSKVPAIGRAGPEQGSSARAASAGPQVSCVQTVPSDGQGVKSRDQRAQEAEVGESRVLETEAEWVPWEVIGTSKTDAGIPESLDTEAGTAESEILEAQESEAARSEGLEPEAAGTAESEVLRTQNNEIVVLGMPRTGPEIREPEEFGETEVGGFTVPDTKTVIAETEILETQGVVDGEAAVLKTQAEISETQKTEAGEAEAGTLESQKVAAEGLGAPEVGAEMAEAEKLGVQETEVEIWRIPRIETETAGTETLGIHKIGPPQMQPRLVGDQETDVSVMETAEDAILGTREITAGCGVLLIEAKIPESKIDRSLETEEGDLGVLEVDTGIAEAKILGIPERAPGVQKALGAGTEVARVLEAEAASSEVPETDAEEAETLQAKERSESSVALRVVANLPESELLGTQKTEVGGTGISQREVREAETEIPKTQEISSEGSGVPDLEAKMEESGRKMEIWETPEVEKVNSELFGTQKGSEIPELETKTIKSEILDAQETEVRDLGLRRGEAEKAEAEMLETQKMEAKTARDEEIELVDPGVSSPEAEALRVQWAGTVVLESGEVKADILGVQKPGSWGALKYEALDVPVTKQRLSGAKEVVPEVPRAQEPETKVLGIVEAKSWTLGQQEAEMEGFESPENKSNIFEAQEADSGVLGTMKGKEAVESLEEAGLSKAQVASEAGAGVPRPSGASSLEEPEEDRRLPGSQAPPTLVSSSQSLLEWCQEVTNGYRGVCITNFTTSWRNGLAFCAILHRFYPDKIDYFSLDPLNIKQNNKQAFDGFAALGVSRLLEPADMVLLSVPDKLIVMTYLCQIRAFCTGQELQLVQLEGGGGSGTYRVGNAQPSLPDCLDAGDLAQRLREHGAEVPTEPKEAVNRGTGAIPKVASRDTDLSCSSKDGEAEVAQEAIPQEAPTDGPRARSSTTPVVPAEGLVNGVGASGGVRLRRSSVNGEAGPVPPPRAHGSFSHVRDADLLKKRRSRLRNSNSFSVDDQDSGAAVGAGPAGPGAVEGPNPASSPDANPLPAPVPQQPPGGPPPTEESSPSLGEEAGLQRFQDTSQYVCAELQALEQEQGQIDGRAAEVEKQLRSLMESGANRLQEEVLIQEWFTLVNKKNALIRRQDQLQLLIEEQDLERRFELLSRELRAMLAIEEWQKTVAQQHREQLLLEELVSLVNQRDELVRDLDQKERIALEEDERLERGLEQRRRKVSRQLSRRERCTLS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
57PhosphorylationRICSKAHSWQPGIQN
CCCCCCCCCCCCCCC		32.0623684622
164PhosphorylationLLREGRATDDDMQSL
HHHCCCCCHHHHHHH		38.3026239621
170PhosphorylationATDDDMQSLASLMSV
CCHHHHHHHHHHHCC		21.1826239621
173PhosphorylationDDMQSLASLMSVKPS
HHHHHHHHHHCCCHH		29.8726239621
176PhosphorylationQSLASLMSVKPSDVG
HHHHHHHCCCHHHCC		32.0826239621
180PhosphorylationSLMSVKPSDVGNLDD
HHHCCCHHHCCCHHH		38.9325159016
191PhosphorylationNLDDFAESDEEEANG
CHHHHHHCHHHHHCC		47.0626824392
214PhosphorylationRGPQSDLSRELKTLC
CCCHHHHHHHHHHHH		28.7929514104
219PhosphorylationDLSRELKTLCEEEDE
HHHHHHHHHHHHCCC		49.6326160508
239PhosphorylationQQAAARPSSAEDTSP
HHHHCCCCCCCCCCC		36.3126160508
240PhosphorylationQAAARPSSAEDTSPA
HHHCCCCCCCCCCCC		38.0627087446
244PhosphorylationRPSSAEDTSPAPVSA
CCCCCCCCCCCCCCC		28.2828066266
245PhosphorylationPSSAEDTSPAPVSAP
CCCCCCCCCCCCCCC		31.2424453211
250PhosphorylationDTSPAPVSAPAPPVR
CCCCCCCCCCCCCCC		27.7228066266
264PhosphorylationRAFRGQGSEPAAITG
CCCCCCCCCCCCCCC		32.3025619855
270PhosphorylationGSEPAAITGGQVGPE
CCCCCCCCCCCCCCC		30.4525619855
278PhosphorylationGGQVGPETPEPPPSP
CCCCCCCCCCCCCCC		35.7627087446
284PhosphorylationETPEPPPSPPETRST
CCCCCCCCCCCCCCC		59.8827087446
288PhosphorylationPPPSPPETRSTGQPG
CCCCCCCCCCCCCCC		35.3827742792
290PhosphorylationPSPPETRSTGQPGQT
CCCCCCCCCCCCCCC		44.2924899341
310PhosphorylationAPRLRKGSDAPSSPV
CCCCCCCCCCCCCCC		33.3725338131
314PhosphorylationRKGSDAPSSPVPCSG
CCCCCCCCCCCCCCC		49.3325338131
367PhosphorylationPDIEVRGSKDSLGGE
CCCEECCCCCCCCCC		23.7925159016
370PhosphorylationEVRGSKDSLGGERSK
EECCCCCCCCCCCHH		32.4225159016
424PhosphorylationQVDAEHKSKVQHRAT
CCCHHHHHHCCHHHC		39.71-
448PhosphorylationPKARLGDTPEAPPRS
CCCCCCCCCCCCCCH		22.6422942356
575 (in isoform 2)Phosphorylation-50.7126060331
576 (in isoform 2)Phosphorylation-30.7426060331
577 (in isoform 2)Phosphorylation-46.6727180971
578 (in isoform 2)Phosphorylation-24.0526026062
583PhosphorylationTDAGIPESLDTEAGT
CCCCCCCCCCCCCCC		26.6228285833
601PhosphorylationEILEAQESEAARSEG
HHHHHHHHHHHHHCC		22.0628285833
604 (in isoform 2)Phosphorylation-16.1029514104
605 (in isoform 2)Phosphorylation-42.1426824392
814PhosphorylationPESKIDRSLETEEGD
CHHHCCCCCCCCCCC		27.1521454597
817PhosphorylationKIDRSLETEEGDLGV
HCCCCCCCCCCCEEE		44.6321454597
829PhosphorylationLGVLEVDTGIAEAKI
EEEEEECCCCEEHHH		35.3521454597
866PhosphorylationVLEAEAASSEVPETD
HHHHHHHCCCCCCCC		33.7925338131
867PhosphorylationLEAEAASSEVPETDA
HHHHHHCCCCCCCCH		37.5825338131
888PhosphorylationQAKERSESSVALRVV
HHHHHCCCHHHHHHH		31.2126824392
889PhosphorylationAKERSESSVALRVVA
HHHHCCCHHHHHHHH		13.8328464351
935PhosphorylationIPKTQEISSEGSGVP
CCCCCCCCCCCCCCC		22.9128285833
936PhosphorylationPKTQEISSEGSGVPD
CCCCCCCCCCCCCCC		52.1928285833
939PhosphorylationQEISSEGSGVPDLEA
CCCCCCCCCCCCHHH		32.3428285833
1040PhosphorylationELVDPGVSSPEAEAL
EEECCCCCCHHHHHH		46.2030635358
1041PhosphorylationLVDPGVSSPEAEALR
EECCCCCCHHHHHHH		25.0928464351
1074PhosphorylationLGVQKPGSWGALKYE
ECCCCCCCCCCCEEE		30.7522817900
1080PhosphorylationGSWGALKYEALDVPV
CCCCCCEEEECCCCC		13.7921183079
1135PhosphorylationAEMEGFESPENKSNI
HHHCCCCCCCCHHCC		34.94-
1187PhosphorylationGAGVPRPSGASSLEE
CCCCCCCCCCCCCCC		48.5525338131
1190PhosphorylationVPRPSGASSLEEPEE
CCCCCCCCCCCCCHH		38.6927742792
1191PhosphorylationPRPSGASSLEEPEED
CCCCCCCCCCCCHHH		38.9927742792
1232GlutathionylationTNGYRGVCITNFTTS
HCCCCCEEEEECCCC		3.3724333276
1269UbiquitinationSLDPLNIKQNNKQAF
ECCCCCCCCCCCHHH		45.99-
1297PhosphorylationPADMVLLSVPDKLIV
CCCEEEECCCCHHHH		27.6927180971
1316PhosphorylationCQIRAFCTGQELQLV
HHHHHHHCCCEEEEE		35.1330635358
1331PhosphorylationQLEGGGGSGTYRVGN
EEECCCCCCCEECCC		31.1030635358
1333PhosphorylationEGGGGSGTYRVGNAQ
ECCCCCCCEECCCCC		15.1730635358
1334PhosphorylationGGGGSGTYRVGNAQP
CCCCCCCEECCCCCC		13.5630635358
1342PhosphorylationRVGNAQPSLPDCLDA
ECCCCCCCCCCCCCH		40.22-
1365PhosphorylationEHGAEVPTEPKEAVN
HCCCCCCCCCHHHHH		70.8326643407
1383PhosphorylationGAIPKVASRDTDLSC
CCCCCHHCCCCCCCC		33.4126824392
1386PhosphorylationPKVASRDTDLSCSSK
CCHHCCCCCCCCCCC		37.4229176673
1389PhosphorylationASRDTDLSCSSKDGE
HCCCCCCCCCCCCCC		18.1125159016
1391PhosphorylationRDTDLSCSSKDGEAE
CCCCCCCCCCCCCHH		36.7326643407
1392PhosphorylationDTDLSCSSKDGEAEV
CCCCCCCCCCCCHHH		38.8125367039
1417PhosphorylationTDGPRARSSTTPVVP
CCCCCCCCCCCCCCC		30.9326745281
1418PhosphorylationDGPRARSSTTPVVPA
CCCCCCCCCCCCCCC		30.6526745281
1419PhosphorylationGPRARSSTTPVVPAE
CCCCCCCCCCCCCCC		36.0426745281
1420PhosphorylationPRARSSTTPVVPAEG
CCCCCCCCCCCCCCC		18.9426745281
1435PhosphorylationLVNGVGASGGVRLRR
CCCCCCCCCCEEEEE		30.1025777480
1443PhosphorylationGGVRLRRSSVNGEAG
CCEEEEECCCCCCCC		32.0025521595
1444PhosphorylationGVRLRRSSVNGEAGP
CEEEEECCCCCCCCC		20.1425521595
1460PhosphorylationPPPRAHGSFSHVRDA
CCCCCCCCCCCCCCH		17.4426824392
1462PhosphorylationPRAHGSFSHVRDADL
CCCCCCCCCCCCHHH		23.8328833060
1704PhosphorylationEQRRRKVSRQLSRRE
HHHHHHHHHHHHHHH		19.83-
1708PhosphorylationRKVSRQLSRRERCTL
HHHHHHHHHHHHCCC		22.43-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of EH1L1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EH1L1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EH1L1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RAB8A_HUMANRAB8Aphysical
26833786
RAB8B_HUMANRAB8Bphysical
26833786
RAB10_HUMANRAB10physical
26833786
RAB13_HUMANRAB13physical
26833786
AMPH_MOUSEAmphphysical
26833786
BIN1_MOUSEBin1physical
26833786
DYN1_MOUSEDnm1physical
26833786
BIN1_HUMANBIN1physical
26833786
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EH1L1_MOUSE

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Related Literatures of Post-Translational Modification

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