EFNA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EFNA2_HUMAN
• UniProt AC: O43921
• Protein Name: Ephrin-A2
• Gene Name: EFNA2
• Organism: Homo sapiens (Human).
• Sequence Length: 213
• Subcellular Localization: Cell membrane ; Lipid-anchor, GPI-anchor .
• Protein Description: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity)..
• Protein Sequence: MAPAQRPLLPLLLLLLPLPPPPFARAEDAARANSDRYAVYWNRSNPRFHAGAGDDGGGYTVEVSINDYLDIYCPHYGAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAPGGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEAPEPIFTSNNSCSSPGGCRLFLSTIPVLWTLLGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	N-linked_Glycosylation	DRYAVYWNRSNPRFH CCEEEEECCCCCCEE	21.58	UniProtKB CARBOHYD
125	Acetylation	AAPGGPLKFSEKFQL CCCCCCCCCCCEECE	50.40	7289869
127	Phosphorylation	PGGPLKFSEKFQLFT CCCCCCCCCEECEEC	37.99	24719451
174	N-linked_Glycosylation	KVYVRPTNETLYEAP EEEECCCCCCCEECC	42.83	UniProtKB CARBOHYD
188	N-linked_Glycosylation	PEPIFTSNNSCSSPG CCCEECCCCCCCCCC	41.18	UniProtKB CARBOHYD
188	GPI-anchor	PEPIFTSNNSCSSPG CCCEECCCCCCCCCC	41.18	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EFNA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EFNA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EFNA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ADA10_HUMAN	ADAM10	physical	10958785
EPHA7_HUMAN	EPHA7	physical	10366629

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.