EF1A2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EF1A2_ARATH
• UniProt AC: Q8W4H7
• Protein Name: Elongation factor 1-alpha 2
• Gene Name: A2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 449
• Subcellular Localization: Cytoplasm.
• Protein Description: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis..
• Protein Sequence: MGKEKFHINIVVIGHVDSGKSTTTGHLIYKLGGIDKRVIERFEKEAAEMNKRSFKYAWVLDKLKAERERGITIDIALWKFETTKYYCTVIDAPGHRDFIKNMITGTSQADCAVLIIDSTTGGFEAGISKDGQTREHALLAFTLGVKQMICCCNKMDATTPKYSKARYDEIIKEVSSYLKKVGYNPDKIPFVPISGFEGDNMIERSTNLDWYKGPTLLEALDQINEPKRPSDKPLRLPLQDVYKIGGIGTVPVGRVETGMIKPGMVVTFAPTGLTTEVKSVEMHHESLLEALPGDNVGFNVKNVAVKDLKRGYVASNSKDDPAKGAANFTSQVIIMNHPGQIGNGYAPVLDCHTSHIAVKFSEILTKIDRRSGKEIEKEPKFLKNGDAGMVKMTPTKPMVVETFSEYPPLGRFAVRDMRQTVAVGVIKSVDKKDPTGAKVTKAAVKKGAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	GHVDSGKSTTTGHLI EECCCCCCCCCCCHH	34.21	25561503
22	Phosphorylation	HVDSGKSTTTGHLIY ECCCCCCCCCCCHHE	31.68	25561503
29	Phosphorylation	TTTGHLIYKLGGIDK CCCCCHHEECCCCCH	13.40	22074104
55	Methylation	EMNKRSFKYAWVLDK HHHHHHHHHHHHHHH	34.99	-
79	Methylation	TIDIALWKFETTKYY EEEEEEEEEECCEEE	33.89	-
85	Phosphorylation	WKFETTKYYCTVIDA EEEECCEEEEEEEEC	11.15	22074104
176	Phosphorylation	EIIKEVSSYLKKVGY HHHHHHHHHHHHHCC	39.39	25561503
177	Phosphorylation	IIKEVSSYLKKVGYN HHHHHHHHHHHHCCC	18.29	25561503
183	Phosphorylation	SYLKKVGYNPDKIPF HHHHHHCCCCCCCCE	26.89	25368622
187	Methylation	KVGYNPDKIPFVPIS HHCCCCCCCCEEECC	54.24	-
194	Phosphorylation	KIPFVPISGFEGDNM CCCEEECCCCCCCCC	31.21	25368622
261	Methylation	RVETGMIKPGMVVTF EEECCCCCCCEEEEE	26.99	-
267	Phosphorylation	IKPGMVVTFAPTGLT CCCCEEEEECCCCCC	11.58	24299221
279	Phosphorylation	GLTTEVKSVEMHHES CCCCEEEEEEEHHHH	28.61	29797451
286	Phosphorylation	SVEMHHESLLEALPG EEEEHHHHHHHHCCC	33.62	29797451
306	Methylation	NVKNVAVKDLKRGYV EEEEEEHHHHCCCEE	47.83	-
312	Phosphorylation	VKDLKRGYVASNSKD HHHHCCCEECCCCCC	9.25	24299221
393	Phosphorylation	DAGMVKMTPTKPMVV CCCCCCCCCCCCEEE	23.30	23776212
395	Phosphorylation	GMVKMTPTKPMVVET CCCCCCCCCCEEEEE	38.32	23776212
396	Methylation	MVKMTPTKPMVVETF CCCCCCCCCEEEEEC	32.11	-
402	Phosphorylation	TKPMVVETFSEYPPL CCCEEEEECCCCCCC	22.35	23776212
420	Phosphorylation	AVRDMRQTVAVGVIK HHCCHHHHEEEEEEE	10.48	23111157
428	Phosphorylation	VAVGVIKSVDKKDPT EEEEEEEECCCCCCC	25.15	23111157
438	Ubiquitination	KKDPTGAKVTKAAVK CCCCCCCCHHHHHHH	52.35	19292762
440	Phosphorylation	DPTGAKVTKAAVKKG CCCCCCHHHHHHHHC	17.79	25561503
441	Ubiquitination	PTGAKVTKAAVKKGA CCCCCHHHHHHHHCC	37.02	19292762

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EF1A2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EF1A2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EF1A2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SUMO3_ARATH	SUMO3	physical	20855607

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Ubiquitylation

"Tandem affinity purification and mass spectrometric analysis ofubiquitylated proteins in Arabidopsis.";
Saracco S.A., Hansson M., Scalf M., Walker J.M., Smith L.M.,Vierstra R.D.;
Plant J. 59:344-358(2009).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-438 AND LYS-441, ANDIDENTIFICATION BY MASS SPECTROMETRY.
PubMed: 19292762