EDR1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EDR1_ARATH
• UniProt AC: Q9FPR3
• Protein Name: Serine/threonine-protein kinase EDR1
• Gene Name: EDR1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 933
• Subcellular Localization: Cell membrane . Endosome . Nucleus. Endoplasmic reticulum. Golgi apparatus, trans-Golgi network. Early endosome. Displays dynamic movement in cells with accumulation at the plasma membrane around pathogenic fungus penetration site (PubMed:25747881).
• Protein Description: MAPKKK serine/threonine-protein kinase involved in the regulation of a MAP kinase cascade (probably including MPK3 and MPK6) that negatively regulates salicylic acid- (SA-) dependent defense responses, abscisic acid (ABA) signaling, and ethylene-induced senescence. Modulates also stress response (e.g. drought) signaling and cell death, in an ORE9-dependent manner. Functions at a point of cross talk between ethylene, ABA and SA signaling that impinges on senescence and cell death. On the other hand, it confers sensitivity to various pathogens such as the fungus E.cichoracearum, the oomycete H.parasitica and the bacteria P.syringae pv. tomato DC3000. Required for resistance to some hemibiotrophic/necrotrophic fungal pathogens (e.g. C.gloeosporioides, C.higginsianum and A.brassicicola) through the induction of defensin expression, probably by repressing MYC2, an inhibitor of defensin genes (PDFs). Together with KEG, may regulate endocytic trafficking and/or the formation of signaling complexes on trans-Golgi network (TGN)/ early endosome (EE) vesicles during stress responses..
• Protein Sequence: MKHIFKKLHRGGNQEQQNRTNDAAPPSDQNRIHVSANPPQATPSSVTETLPVAGATSSMASPAPTAASNRADYMSSEEEYQVQLALAISASNSQSSEDPEKHQIRAATLLSLGSHQRMDSRRDSSEVVAQRLSRQYWEYGVLDYEEKVVDSFYDVYSLSTDSAKQGEMPSLEDLESNHGTPGFEAVVVNRPIDSSLHELLEIAECIALGCSTTSVSVLVQRLAELVTEHMGGSAEDSSIVLARWTEKSSEFKAALNTCVFPIGFVKIGISRHRALLFKVLADSVRLPCRLVKGSHYTGNEDDAVNTIRLEDEREYLVDLMTDPGTLIPADFASASNNTVEPCNSNGNKFPTAQFSNDVPKLSEGEGSSHSSMANYSSSLDRRTEAERTDSSYPKVGPLRNIDYSSPSSVTSSTQLENNSSTAIGKGSRGAIIECSRTNMNIVPYNQNSEEDPKNLFADLNPFQNKGADKLYMPTKSGLNNVDDFHQQKNNPLVGRSPAPMMWKNYSCNEAPKRKENSYIENLLPKLHRDPRYGNTQSSYATSSSNGAISSNVHGRDNVTFVSPVAVPSSFTSTENQFRPSIVEDMNRNTNNELDLQPHTAAVVHGQQNDESHIHDHRKYTSDDISTGCDPRLKDHESTSSSLDSTSYRNDPQVLDDADVGECEIPWNDLVIAERIGLGSYGEVYHADWHGTEVAVKKFLDQDFSGAALAEFRSEVRIMRRLRHPNVVFFLGAVTRPPNLSIVTEFLPRGSLYRILHRPKSHIDERRRIKMALDVAMGMNCLHTSTPTIVHRDLKTPNLLVDNNWNVKVGDFGLSRLKHNTFLSSKSTAGTPEWMAPEVLRNEPSNEKCDVYSFGVILWELATLRLPWRGMNPMQVVGAVGFQNRRLEIPKELDPVVGRIILECWQTDPNLRPSFAQLTEVLKPLNRLVLPTPQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
108	Phosphorylation	KHQIRAATLLSLGSH HHHHHHHHHHHHCCC		23776212
111	Phosphorylation	IRAATLLSLGSHQRM HHHHHHHHHCCCCCC		23776212
114	Phosphorylation	ATLLSLGSHQRMDSR HHHHHHCCCCCCCCC		23776212
124	Phosphorylation	RMDSRRDSSEVVAQR CCCCCCCCHHHHHHH		25561503
214	Phosphorylation	ALGCSTTSVSVLVQR HHCCCHHHHHHHHHH		28011693
216	Phosphorylation	GCSTTSVSVLVQRLA CCCHHHHHHHHHHHH		28011693
476	Phosphorylation	KLYMPTKSGLNNVDD CCCCCCCCCCCCHHH		30407730
549	Phosphorylation	SSSNGAISSNVHGRD CCCCCCCCCCCCCCC		30407730
550	Phosphorylation	SSNGAISSNVHGRDN CCCCCCCCCCCCCCC		30407730
823	Phosphorylation	LKHNTFLSSKSTAGT HCCCCCCCCCCCCCC		25561503
824	Phosphorylation	KHNTFLSSKSTAGTP CCCCCCCCCCCCCCC		25561503
826	Phosphorylation	NTFLSSKSTAGTPEW CCCCCCCCCCCCCCC		15308754
827	Phosphorylation	TFLSSKSTAGTPEWM CCCCCCCCCCCCCCC		15308754
830	Phosphorylation	SSKSTAGTPEWMAPE CCCCCCCCCCCCCHH		23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EDR1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EDR1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EDR1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KEG_ARATH	KEG	physical	21343429
ATL1_ARATH	AT1G04360	physical	25398498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.