DYR1A_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DYR1A_RAT
• UniProt AC: Q63470
• Protein Name: Dual specificity tyrosine-phosphorylation-regulated kinase 1A
• Gene Name: Dyrk1a
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 763
• Subcellular Localization: Nucleus speckle .
• Protein Description: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity)..
• Protein Sequence: MHTGGETSACKPSSVRLAPSFSFHAAGLQMAAQMPHSHQYSDRRQPNISDQQVSALSYSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWSLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFAAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	TSACKPSSVRLAPSF CCCCCCCCCCCCCCC	21.56	-
104	Phosphorylation	SVDLIKTYKHINEVY CHHHHHHHHHHHHHH	8.79	-
105	Acetylation	VDLIKTYKHINEVYY HHHHHHHHHHHHHHH	43.15	22902405
111	Phosphorylation	YKHINEVYYAKKKRR HHHHHHHHHHHHHHH	7.48	-
140	Phosphorylation	RKVYNDGYDDDNYDY HHCCCCCCCCCCCCE	21.04	-
145	Phosphorylation	DGYDDDNYDYIVKNG CCCCCCCCCEEEECC	19.67	-
147	Phosphorylation	YDDDNYDYIVKNGEK CCCCCCCEEEECCCC	9.39	-
159	Phosphorylation	GEKWMDRYEIDSLIG CCCEECCEECHHHCC	16.99	-
177	Phosphorylation	FGQVVKAYDRVEQEW HHHHHHHHHHHHHEE	9.88	-
219	Phosphorylation	KHDTEMKYYIVHLKR HCCCHHHHHHHHHHH	9.34	8631952
310	Phosphorylation	IKIVDFGSSCQLGQR EEEEECCCCCHHHHH	28.12	-
319	Phosphorylation	CQLGQRIYQYIQSRF CHHHHHHHHHHHHHH	9.46	27097102
321	Phosphorylation	LGQRIYQYIQSRFYR HHHHHHHHHHHHHCC	5.51	23712012
324	Phosphorylation	RIYQYIQSRFYRSPE HHHHHHHHHHCCCHH	18.13	27097102
402	Phosphorylation	FEKLPDGTWSLKKTK HHCCCCCCCCEEECC	21.18	-
449	Phosphorylation	SGHTVADYLKFKDLI CCCCHHHHHHHHHHH	11.31	-
489	Phosphorylation	TADEGTNTSNSVSTS CCCCCCCCCCCCCCC	29.17	28689409
496	Phosphorylation	TSNSVSTSPAMEQSQ CCCCCCCCCHHHCHH	11.80	28689409
529	Phosphorylation	SNSGRARSDPTHQHR CCCCCCCCCCCCCCC	47.13	29779826
532	Phosphorylation	GRARSDPTHQHRHSG CCCCCCCCCCCCCCC	38.88	25575281
538	Phosphorylation	PTHQHRHSGGHFAAA CCCCCCCCCCHHHHH	46.56	28432305
553	Phosphorylation	VQAMDCETHSPQVRQ HHHHCCCCCCHHHHH	33.70	28432305
555	Phosphorylation	AMDCETHSPQVRQQF HHCCCCCCHHHHHHC	25.17	28432305
748	Phosphorylation	QGADREESPMTGVCV CCCCCCCCCCCCEEE	18.41	27097102
751	Phosphorylation	DREESPMTGVCVQQS CCCCCCCCCEEEECC	29.82	27097102
758	Phosphorylation	TGVCVQQSPVASS-- CCEEEECCCCCCC--	12.30	27097102
762	Phosphorylation	VQQSPVASS------ EECCCCCCC------	36.49	27097102
763	Phosphorylation	QQSPVASS------- ECCCCCCC-------	34.21	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
97	S	Phosphorylation	Kinase	DYRK1A	Q63470	GPS
111	Y	Phosphorylation	Kinase	DYRK1A	Q63470	GPS
219	Y	Phosphorylation	Kinase	DYRK1A	Q63470	PSP
319	Y	Phosphorylation	Kinase	DYRK1A	Q63470	GPS
321	Y	Phosphorylation	Kinase	DYRK1A	Q63470	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DYR1A_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DYR1A_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DCAF7_HUMAN	DCAF7	physical	27307198

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Dyrk, a dual specificity protein kinase with unique structuralfeatures whose activity is dependent on tyrosine residues betweensubdomains VII and VIII.";
Kentrup H., Becker W., Heukelbach J., Wilmes A., Schuermann A.,Huppertz C., Kainulainen H., Joost H.-G.;
J. Biol. Chem. 271:3488-3495(1996).
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), FUNCTION, TISSUESPECIFICITY, AUTOPHOSPHORYLATION AT TYR-219; TYR-319 AND TYR-321, ANDMUTAGENESIS OF LYS-188; TYR-219; TYR-319 AND TYR-321.
PubMed: 8631952