DRIP1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DRIP1_ARATH
• UniProt AC: Q9M9Y4
• Protein Name: E3 ubiquitin protein ligase DRIP1
• Gene Name: DRIP1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 421
• Subcellular Localization: Nucleus .
• Protein Description: E3 ubiquitin-protein ligase that acts as a negative regulator of the response to water stress. Mediates ubiquitination and subsequent proteasomal degradation of the drought-induced transcriptional activator DREB2A. Functionally redundant with DRIP2..
• Protein Sequence: MMIKVKKETMRACLSCSICDNILRDATTISECLHTFCRKCIYEKITEDEIETCPVCNIDLGSTPLEKLRPDHNLQDLRAKIFALKRRKVKAPGIVSLPGKRKERSISSLVVSTPMVSAQAGTTRRRTKAPTRKELRNGSLAERTVKKEESSGDELLESTSSPDTLNKFTQNKRQSKKSCKESISNKENKDGDEPWDSKMDWKPLNFLVEVANGTKPLKSSASQGSGSKSEHANVSRNQFQGSKTKTKNKKRKCKREDDKSNNGDPTTSETVTPKRMRTTQRKRSATTLGDSRNLPQPDESSAKQERRNGPVWFSLVASNDQEGGTSLPQIPANFLRIRDGNTTVSFIQKYLMRKLDLESENEIEIKCMGEAVIPTLTLYNLVDLWLQKSSNHQRFAALVGSSAKDFTMVLVYARKLPECNM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
150	Phosphorylation	RTVKKEESSGDELLE HEECHHHCCHHHHHH	40.49	30407730
151	Phosphorylation	TVKKEESSGDELLES EECHHHCCHHHHHHH	54.25	30407730
158	Phosphorylation	SGDELLESTSSPDTL CHHHHHHHCCCHHHH	33.29	30407730
159	Phosphorylation	GDELLESTSSPDTLN HHHHHHHCCCHHHHH	24.69	30407730
160	Phosphorylation	DELLESTSSPDTLNK HHHHHHCCCHHHHHH	49.50	30407730
161	Phosphorylation	ELLESTSSPDTLNKF HHHHHCCCHHHHHHH	27.21	30407730
284	Phosphorylation	RTTQRKRSATTLGDS CCCCCCCCCCCCCCC	32.76	29654922
286	Phosphorylation	TQRKRSATTLGDSRN CCCCCCCCCCCCCCC	24.65	25561503
287	Phosphorylation	QRKRSATTLGDSRNL CCCCCCCCCCCCCCC	28.58	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SAP5	Q9LHJ8	PMID:29089392

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DRIP1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DRIP1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DRE2A_ARATH	DREB2A	physical	18552202
DRIP1_ARATH	DRIP1	physical	18552202

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.