DPP6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DPP6_MOUSE
• UniProt AC: Q9Z218
• Protein Name: Dipeptidyl aminopeptidase-like protein 6
• Gene Name: Dpp6
• Organism: Mus musculus (Mouse).
• Sequence Length: 804
• Subcellular Localization: Cell membrane ; Single-pass type II membrane protein .
• Protein Description: Promotes cell surface expression of the potassium channel KCND2. [PubMed: 22311982 Modulates the activity and gating characteristics of the potassium channel KCND2]
• Protein Sequence: MNQTAGASNNVRCPPGKGHKELVGSNPPQRNWKGIAIALLVILVICSLIVTSVILLTPAEDTSLSQKKKVTVEDLFSEDFKIHDPEAKWISNKEFIYRERKGSVILRNVETNNSTVLIEGKKIESLRAIRYEISPDKEYVLFSYNVEPVYQHSHTGYYVLSKIPHGDPQSLDPPEVSNAKLQYAGWGPKGQQLIFIFENNIYYCAHVGKQAIRVVSTGKEGVIYNGLSDWLYEEEILKSHIAHWWSPDGTRLAYATINDSRVPLMELPTYTGSVYPTVKPYHYPKAGSENPSISLHVIGLNGPTHDLEMMPPDDPRMREYYITMVKWATSTKVAVTWLNRAQNVSILTLCDATTGVCTKKHEDESEAWLHRQNEEPVFSKDGRKFFFVRAIPQGGRGKFYHITVSSSQPNSSNDNIQSITSGDWDVTKILSYDEKRNKIYFLSTEDLPRRRHLYSANTVDDFNRQCLSCDLVENCTYVSASFSHNMDFFLLKCEGPGVPTVTVHNTTDKRRMFDLEANEEVQKAINDRQMPKIEYRKIEVEDYSLPMQILKPATFTDTAHYPLLLVVDGTPGSQSVTERFEVTWETVLVSSHGAVVVKCDGRGSGFQGTKLLQEVRRRLGFLEEKDQMEAVRTMLKEQYIDKTRVAVFGKDYGGYLSTYILPAKGENQGQTFTCGSALSPITDFKLYASAFSERYLGLHGLDNRAYEMTKLAHRVSALEDQQFLIIHATADEKIHFQHTAELITQLIKGKANYSLQIYPDESHYFHSVALKQHLSRSIIGFFVECFRVQDKLPTATAKEEEEED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
112	N-linked_Glycosylation	ILRNVETNNSTVLIE EEEECCCCCCEEEEC	27.27	-
113	N-linked_Glycosylation	LRNVETNNSTVLIEG EEECCCCCCEEEECC	46.61	-
143	Phosphorylation	DKEYVLFSYNVEPVY CCCEEEEEEEEEEEE	16.19	28576409
177	Phosphorylation	SLDPPEVSNAKLQYA HCCCCCCCCCEEEEC	29.43	-
258	N-linked_Glycosylation	RLAYATINDSRVPLM EEEEEEECCCCCCEE	36.53	-
343	N-linked_Glycosylation	TWLNRAQNVSILTLC HHHHHCCCEEEEEEE	28.63	-
410	N-linked_Glycosylation	TVSSSQPNSSNDNIQ EEECCCCCCCCCCCE	50.89	-
474	N-linked_Glycosylation	LSCDLVENCTYVSAS HCCCCCCCCEEEEEE	18.89	-
505	N-linked_Glycosylation	VPTVTVHNTTDKRRM CCEEEEECCCCCCCC	40.10	-
602	Dimethylation	VVVKCDGRGSGFQGT EEEEECCCCCCCHHH	23.89	-
674	S-nitrosylation	NQGQTFTCGSALSPI CCCCEEECCCCCCCC	3.37	22588120
710	Acetylation	NRAYEMTKLAHRVSA CHHHHHHHHHHHHHH	42.22	55169029
752	N-linked_Glycosylation	QLIKGKANYSLQIYP HHHHCCCCEEEEECC	30.34	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DPP6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DPP6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DPP6_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DPP6_MOUSE	Dpp6	physical	24225951
PRIO_MOUSE	Prnp	physical	24225951
PRND_MOUSE	Prnd	physical	24225951

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.