dbPTM

DPP10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DPP10_HUMAN
UniProt AC	Q8N608
Protein Name	Inactive dipeptidyl peptidase 10
Gene Name	DPP10
Organism	Homo sapiens (Human).
Sequence Length	796
Subcellular Localization	Cell membrane Single-pass type II membrane protein .
Protein Description	Promotes cell surface expression of the potassium channel KCND2. [PubMed: 15454437 Modulates the activity and gating characteristics of the potassium channel KCND2]
Protein Sequence	MNQTASVSHHIKCQPSKTIKELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLTPDELTNSSETRLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNIETNATTLLLENTTFVTFKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSLVPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTHTLELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRAQNISILTVCETTTGACSKKYEMTSDTWLSQQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHVAMFLIQSKSEQITVRHLTSGNWEVIKILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQHFLLFCEGPRVPVVSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIKILHIDDYELPLQLSLPKDFMDRNQYALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQGLKILQEIHRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVVAPITDLKLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHGTADTKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDCLKEEISVLPQEPEEDE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	Phosphorylation	LLTPDELTNSSETRL HCCHHHCCCCCCCCC	30.89	29083192
64	Phosphorylation	TPDELTNSSETRLSL CHHHCCCCCCCCCCH	25.06	29083192
65	Phosphorylation	PDELTNSSETRLSLE HHHCCCCCCCCCCHH	45.09	29083192
67	Phosphorylation	ELTNSSETRLSLEDL HCCCCCCCCCCHHHH	38.57	29083192
90	N-linked_Glycosylation	DPEARWINDTDVVYK CCCCCEECCCCEEEE	38.89	22387313
111	N-linked_Glycosylation	IKLNIETNATTLLLE EEEEEECCCEEEEEE	23.62	22387313
119	N-linked_Glycosylation	ATTLLLENTTFVTFK CEEEEEECCEEEEEE	44.37	22387313
131	Phosphorylation	TFKASRHSVSPDLKY EEEECCCCCCCCHHH	24.15	25278378
133	Phosphorylation	KASRHSVSPDLKYVL EECCCCCCCCHHHEE	18.73	18669648
138	Phosphorylation	SVSPDLKYVLLAYDV CCCCCHHHEEEEEEH	12.02	18669648
143	Phosphorylation	LKYVLLAYDVKQIFH HHHEEEEEEHHHHHC	22.65	12662155
257	N-linked_Glycosylation	RLAFLMINDSLVPTM EEEEEEECCCCCCCC	20.89	22387313
270	Phosphorylation	TMVIPRFTGALYPKG CCCCCCCCCCCCCCC	23.87	-
274	Phosphorylation	PRFTGALYPKGKQYP CCCCCCCCCCCCCCC	11.45	-
280	Phosphorylation	LYPKGKQYPYPKAGQ CCCCCCCCCCCCCCC	14.28	-
282	Phosphorylation	PKGKQYPYPKAGQVN CCCCCCCCCCCCCCC	16.66	-
291	Phosphorylation	KAGQVNPTIKLYVVN CCCCCCCEEEEEEEE	26.07	28060719
316	Phosphorylation	MPPDSFKSREYYITM CCCCCCCCCCEEEEE	28.47	-
319	Phosphorylation	DSFKSREYYITMVKW CCCCCCCEEEEEEEE	10.08	-
320	Phosphorylation	SFKSREYYITMVKWV CCCCCCEEEEEEEEH	5.78	-
328	Phosphorylation	ITMVKWVSNTKTVVR EEEEEEHHCHHHHHH	37.35	-
342	N-linked_Glycosylation	RWLNRAQNISILTVC HHHHHHCCEEEEEEE	29.05	22387313
414	Phosphorylation	QSKSEQITVRHLTSG ECCCCEEEEEEECCC	15.92	23312004
467	Phosphorylation	LLNRQCISCNFMKEQ HCCCCCCCCCCCHHH	15.61	17081983
481	Phosphorylation	QCTYFDASFSPMNQH HCCEEECCCCCCCCE	28.27	17081983
483	Phosphorylation	TYFDASFSPMNQHFL CEEECCCCCCCCEEE	22.27	17081983
512	Phosphorylation	STDNPAKYFILESNS CCCCCCCEEEEECCH	9.65	-
519	Phosphorylation	YFILESNSMLKEAIL EEEEECCHHHHHHHH	34.47	24076635
639	Phosphorylation	KFLLKLPYIDSKRLS HHHHCCCCCCCCCEE	28.00	23909892
642	Phosphorylation	LKLPYIDSKRLSIFG HCCCCCCCCCEEECC	15.32	23909892
669	Acetylation	KSDEKLFKCGSVVAP CCCHHHCCCCCEEEE	48.39	7366057
729	Acetylation	IHGTADTKVHFQHSA EEECCCCCHHCHHHH	33.97	30588301
748	N-linked_Glycosylation	HLIKAGVNYTMQVYP HHHHHCCCEEEEECC	26.16	22387313
754	Phosphorylation	VNYTMQVYPDEGHNV CCEEEEECCCCCCCC	6.51	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DPP10_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
257	N	Glycosylation		22387313
N-glycosylation is important for cell surface expression, specially at Asn-257, which is crucial.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DPP10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
DPP10_HUMAN	DPP10	physical	22387313
KCND2_HUMAN	KCND2	physical	15454437

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
600807	Asthma (ASTHMA)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DPP10_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"N-glycosylation of the mammalian dipeptidyl aminopeptidase-likeprotein 10 (DPP10) regulates trafficking and interaction with Kv4channels."; Cotella D., Radicke S., Cipriani V., Cavaletto M., Merlin S.,Follenzi A., Ravens U., Wettwer E., Santoro C., Sblattero D.; Int. J. Biochem. Cell Biol. 44:876-885(2012). Cited for: GLYCOSYLATION AT ASN-90; ASN-111; ASN-119; ASN-257; ASN-342 ANDASN-748, AND MUTAGENESIS OF ASN-257.	22387313 [Abstract]
Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-133; TYR-138 ANDTYR-143, AND MASS SPECTROMETRY.	18669648 [Abstract]

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