DPEP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DPEP3_HUMAN
• UniProt AC: Q9H4B8
• Protein Name: Dipeptidase 3
• Gene Name: DPEP3
• Organism: Homo sapiens (Human).
• Sequence Length: 488
• Subcellular Localization: Membrane; Lipid-anchor, GPI-anchor.
• Protein Description: Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis (By similarity)..
• Protein Sequence: MQPTGREGSRALSRRYLRRLLLLLLLLLLRQPVTRAETTPGAPRALSTLGSPSLFTTPGVPSALTTPGLTTPGTPKTLDLRGRAQALMRSFPLVDGHNDLPQVLRQRYKNVLQDVNLRNFSHGQTSLDRLRDGLVGAQFWSASVSCQSQDQTAVRLALEQIDLIHRMCASYSELELVTSAEGLNSSQKLACLIGVEGGHSLDSSLSVLRSFYVLGVRYLTLTFTCSTPWAESSTKFRHHMYTNVSGLTSFGEKVVEELNRLGMMIDLSYASDTLIRRVLEVSQAPVIFSHSAARAVCDNLLNVPDDILQLLKKNGGIVMVTLSMGVLQCNLLANVSTVADHFDHIRAVIGSEFIGIGGNYDGTGRFPQGLEDVSTYPVLIEELLSRSWSEEELQGVLRGNLLRVFRQVEKVREESRAQSPVEAEFPYGQLSTSCHSHLVPQNGHQATHLEVTKQPTNRVPWRSSNASPYLVPGLVAAATIPTFTQWLC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	Phosphorylation	PGAPRALSTLGSPSL CCCCCHHHHCCCCHH	22.17	22210691
51	Phosphorylation	RALSTLGSPSLFTTP CHHHHCCCCHHCCCC	17.90	22210691
206	Phosphorylation	HSLDSSLSVLRSFYV CCHHHHHHHHHHHHH	22.51	24719451
241	Phosphorylation	TKFRHHMYTNVSGLT HHHCCHHCCCCCCCC	7.27	-
242	Phosphorylation	KFRHHMYTNVSGLTS HHCCHHCCCCCCCCH	22.90	-
334	N-linked_Glycosylation	LQCNLLANVSTVADH HHHCHHCCCHHHHHH	28.39	UniProtKB CARBOHYD
385	Phosphorylation	VLIEELLSRSWSEEE HHHHHHHHCCCCHHH	36.57	24719451
463	GPI-anchor	TNRVPWRSSNASPYL CCCCCCCCCCCCCCC	24.87	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DPEP3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DPEP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DPEP3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DPEP2_HUMAN	DPEP2	physical	28514442
CALX_HUMAN	CANX	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.