| UniProt ID | DOK7_HUMAN | |
|---|---|---|
| UniProt AC | Q18PE1 | |
| Protein Name | Protein Dok-7 | |
| Gene Name | DOK7 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 504 | |
| Subcellular Localization |
Cell membrane Peripheral membrane protein. Cell junction, synapse. Accumulates at neuromuscular junctions.. |
|
| Protein Description | Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK.. | |
| Protein Sequence | MTEAALVEGQVKLRDGKKWKSRWLVLRKPSPVADCLLMLVYKDKSERIKGLRERSSLTLEDICGLEPGLPYEGLVHTLAIVCLSQAIMLGFDSHEAMCAWDARIRYALGEVHRFHVTVAPGTKLESGPATLHLCNDVLVLARDIPPAVTGQWKLSDLRRYGAVPSGFIFEGGTRCGYWAGVFFLSSAEGEQISFLFDCIVRGISPTKGPFGLRPVLPDPSPPGPSTVEERVAQEALETLQLEKRLSLLSHAGRPGSGGDDRSLSSSSSEASHLDVSASSRLTAWPEQSSSSASTSQEGPRPAAAQAAGEAMVGASRPPPKPLRPRQLQEVGRQSSSDSGIATGSHSSYSSSLSSYAGSSLDVWRATDELGSLLSLPAAGAPEPSLCTCLPGTVEYQVPTSLRAHYDTPRSLCLAPRDHSPPSQGSPGNSAARDSGGQTSAGCPSGWLGTRRRGLVMEAPQGSEATLPGPAPGEPWEAGGPHAGPPPAFFSACPVCGGLKVNPPP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 155 | Phosphorylation | VTGQWKLSDLRRYGA CCCCEEHHHHHHHCC | 30.76 | 24719451 | |
| 204 | Phosphorylation | DCIVRGISPTKGPFG HHHHCCCCCCCCCCC | 29.37 | 24719451 | |
| 220 | Phosphorylation | RPVLPDPSPPGPSTV CCCCCCCCCCCCCHH | 51.62 | 24719451 | |
| 246 | Phosphorylation | LQLEKRLSLLSHAGR HHHHHHHHHHHHCCC | 31.15 | 29214152 | |
| 249 | Phosphorylation | EKRLSLLSHAGRPGS HHHHHHHHHCCCCCC | 19.31 | 29214152 | |
| 256 | Phosphorylation | SHAGRPGSGGDDRSL HHCCCCCCCCCCCCC | 42.14 | 24719451 | |
| 405 | Phosphorylation | PTSLRAHYDTPRSLC CCCHHHCCCCCHHHE | 22.11 | - | |
| 407 | Phosphorylation | SLRAHYDTPRSLCLA CHHHCCCCCHHHEEC | 17.27 | 28555341 | |
| 410 | Phosphorylation | AHYDTPRSLCLAPRD HCCCCCHHHEECCCC | 25.33 | 28555341 | |
| 419 | Phosphorylation | CLAPRDHSPPSQGSP EECCCCCCCCCCCCC | 42.68 | 22617229 | |
| 422 | Phosphorylation | PRDHSPPSQGSPGNS CCCCCCCCCCCCCCC | 51.02 | 22617229 | |
| 425 | Phosphorylation | HSPPSQGSPGNSAAR CCCCCCCCCCCCCCC | 23.23 | 21712546 | |
| 429 | Phosphorylation | SQGSPGNSAARDSGG CCCCCCCCCCCCCCC | 29.26 | 26330541 | |
| 536 (in isoform 3) | Phosphorylation | - | 22210691 | ||
| 545 (in isoform 3) | Phosphorylation | - | 22210691 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DOK7_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DOK7_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DOK7_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MPZL1_HUMAN | MPZL1 | physical | 25814554 | |
| EFHC1_HUMAN | EFHC1 | physical | 25814554 | |
| YPEL3_HUMAN | YPEL3 | physical | 25814554 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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