DNLI4_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DNLI4_ARATH
• UniProt AC: Q9LL84
• Protein Name: DNA ligase 4
• Gene Name: LIG4
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1219
• Subcellular Localization: Nucleus.
• Protein Description: Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair. May be involved for T-DNA integration even if not absolutely required. Seems to be dispensable under normal growth conditions..
• Protein Sequence: MTEEIKFSVLVSLFNWIQKSKTSSQKRSKFRKFLDTYCKPSDYFVAVRLIIPSLDRERGSYGLKESVLATCLIDALGISRDAPDAVRLLNWRKGGTAKAGANAGNFSLIAAEVLQRRQGMASGGLTIKELNDLLDRLASSENRAEKTLVLSTLIQKTNAQEMKWVIRIILKDLKLGMSEKSIFQEFHPDAEDLFNVTCDLKLVCEKLRDRHQRHKRQDIEVGKAVRPQLAMRIGDVNAAWKKLHGKDVVAECKFDGDRIQIHKNGTDIHYFSRNFLDHSEYAHAMSDLIVQNILVDKCILDGEMLVWDTSLNRFAEFGSNQEIAKAAREGLDSHKQLCYVAFDVLYVGDTSVIHQSLKERHELLKKVVKPLKGRLEVLVPEGGLNVHRPSGEPSWSIVVHAAADVERFFKETVENRDEGIVLKDLESKWEPGDRSGKWMKLKPEYIRAGADLDVLIIGGYYGSGRRGGEVAQFLVALADRAEANVYPRRFMSFCRVGTGLSDDELNTVVSKLKPYFRKNEHPKKAPPSFYQVTNHSKERPDVWIDSPEKSIILSITSDIRTIRSEVFVAPYSLRFPRIDKVRYDKPWHECLDVQAFVELVNSSNGTTQKQKESESTQDNPKVNKSSKRGEKKNVSLVPSQFIQTDVSDIKGKTSIFSNMIFYFVNVPRSHSLETFHKMVVENGGKFSMNLNNSVTHCIAAESSGIKYQAAKRQRDVIHFSWVLDCCSRNKMLPLLPKYFLHLTDASRTKLQDDIDEFSDSYYWDLDLEGLKQVLSNAKQSEDSKSIDYYKKKLCPEKRWSCLLSCCVYFYPYSQTLSTEEEALLGIMAKRLMLEVLMAGGKVSNNLAHASHLVVLAMAEEPLDFTLVSKSFSEMEKRLLLKKRLHVVSSHWLEESLQREEKLCEDVYTLRPKYMEESDTEESDKSEHDTTEVASQGSAQTKEPASSKIAITSSRGRSNTRAVKRGRSSTNSLQRVQRRRGKQPSKISGDETEESDASEEKVSTRLSDIAEETDSFGEAQRNSSRGKCAKRGKSRVGQTQRVQRSRRGKKAAKIGGDESDENDELDGNNNVSADAEEGNAAGRSVENEETREPDIAKYTESQQRDNTVAVEEALQDSRNAKTEMDMKEKLQIHEDPLQAMLMKMFPIPSQKTTETSNRTTGEYRKANVSGECESSEKRKLDAETDNTSVNAGAESDVVPPLVKKKKVSYRDVAGELLKDW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
987	Phosphorylation	GKQPSKISGDETEES CCCCCCCCCCCCCCC	43.88	23776212
991	Phosphorylation	SKISGDETEESDASE CCCCCCCCCCCCCCC	50.20	23776212
994	Phosphorylation	SGDETEESDASEEKV CCCCCCCCCCCCHHH	32.04	23776212
997	Phosphorylation	ETEESDASEEKVSTR CCCCCCCCCHHHHHH	51.81	23776212
1002	Phosphorylation	DASEEKVSTRLSDIA CCCCHHHHHHHHHHH	20.91	23776212
1003	Phosphorylation	ASEEKVSTRLSDIAE CCCHHHHHHHHHHHH	38.32	23776212
1012	Phosphorylation	LSDIAEETDSFGEAQ HHHHHHHCCCHHHHH	28.57	30407730
1014	Phosphorylation	DIAEETDSFGEAQRN HHHHHCCCHHHHHHH	42.44	30291188
1058	Phosphorylation	AKIGGDESDENDELD HHCCCCCCCCCCCCC	55.77	30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DNLI4_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DNLI4_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DNLI4_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
XRCC4_ARATH	XRCC4	physical	11029705

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.