DIRA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DIRA2_HUMAN
• UniProt AC: Q96HU8
• Protein Name: GTP-binding protein Di-Ras2
• Gene Name: DIRAS2
• Organism: Homo sapiens (Human).
• Sequence Length: 199
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side .
• Protein Description: Displays low GTPase activity and exists predominantly in the GTP-bound form..
• Protein Sequence: MPEQSNDYRVAVFGAGGVGKSSLVLRFVKGTFRESYIPTVEDTYRQVISCDKSICTLQITDTTGSHQFPAMQRLSISKGHAFILVYSITSRQSLEELKPIYEQICEIKGDVESIPIMLVGNKCDESPSREVQSSEAEALARTWKCAFMETSAKLNHNVKELFQELLNLEKRRTVSLQIDGKKSKQQKRKEKLKGKCVIM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	AGGVGKSSLVLRFVK CCCCCCHHHHHHHHC	26.44	20860994
29	Ubiquitination	SLVLRFVKGTFRESY HHHHHHHCCCCHHHC	49.90	21890473
31	Phosphorylation	VLRFVKGTFRESYIP HHHHHCCCCHHHCCC	17.50	28857561
35	Phosphorylation	VKGTFRESYIPTVED HCCCCHHHCCCCHHH	24.89	28857561
75	Phosphorylation	FPAMQRLSISKGHAF CCCEEEEEECCCCEE	27.31	29496963
77	Phosphorylation	AMQRLSISKGHAFIL CEEEEEECCCCEEEE	29.25	26699800
113	Phosphorylation	EIKGDVESIPIMLVG HHCCCHHHCCEEEEC	33.25	23879269
126	Phosphorylation	VGNKCDESPSREVQS ECCCCCCCCCCCCCH	18.22	-
175	Phosphorylation	LEKRRTVSLQIDGKK CHHHCEEEEEECCCC	17.59	26074081
189	Acetylation	KSKQQKRKEKLKGKC CHHHHHHHHHHCCCE	67.26	90827
191	Acetylation	KQQKRKEKLKGKCVI HHHHHHHHHCCCEEE	59.54	90831
196	Methylation	KEKLKGKCVIM---- HHHHCCCEEEC----	3.23	-
196	Geranylgeranylation	KEKLKGKCVIM---- HHHHCCCEEEC----	3.23	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DIRA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DIRA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DIRA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UN13B_HUMAN	UNC13B	physical	28514442
GDS1_HUMAN	RAP1GDS1	physical	28514442
FTO_HUMAN	FTO	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.