DHB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DHB1_HUMAN
• UniProt AC: P14061
• Protein Name: Estradiol 17-beta-dehydrogenase 1
• Gene Name: HSD17B1
• Organism: Homo sapiens (Human).
• Sequence Length: 328
• Subcellular Localization: Cytoplasm.
• Protein Description: Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH..
• Protein Sequence: MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGGGAGPGAEDEAGRGAVGDPELGDPPAAPQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	ATLRDLKTQGRLWEA EEHHHHHHHCHHHHH	43.48	29083192
59	Phosphorylation	ALACPPGSLETLQLD HHCCCCCCEEEEEEE	28.89	28348404
135	Phosphorylation	PDMKRRGSGRVLVTG HHHHHCCCCCEEEEC	22.93	8994190
200	Phosphorylation	FMEKVLGSPEEVLDR HHHHHHCCHHHHHCC	25.61	28348404
243	Phosphorylation	EVAEVFLTALRAPKP HHHHHHHHHHHCCCC	16.51	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
135	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DHB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DHB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DHB1_HUMAN	HSD17B1	physical	9525918

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.