DHB13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DHB13_HUMAN
• UniProt AC: Q7Z5P4
• Protein Name: 17-beta-hydroxysteroid dehydrogenase 13
• Gene Name: HSD17B13
• Organism: Homo sapiens (Human).
• Sequence Length: 300
• Subcellular Localization: Secreted .
• Protein Sequence: MNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTRLWPVLETDEVVRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERASAILNRMQNIQFEAVVGHKIKMK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	O-linked_Glycosylation	IIYSYLESLVKFFIP HHHHHHHHHHHHHCC	35.55	29351928
33	Phosphorylation	FIPQRRKSVAGEIVL HCCCCCCCCCCEEEE	18.52	20166139
42	Phosphorylation	AGEIVLITGAGHGIG CCEEEEECCCCCCCC	19.47	21902226
61	Phosphorylation	YEFAKRQSILVLWDI HHHHHHCCEEEEEEC	23.17	-
108	Acetylation	YRSLNQVKKEVGDVT HHHHHHHCHHHCCEE	33.19	22368407
109	Acetylation	RSLNQVKKEVGDVTI HHHHHHCHHHCCEEE	59.79	22368415
131	Phosphorylation	VYPADLLSTKDEEIT EEEHHHHCCCCCHHH	40.48	24719451
139	Acetylation	TKDEEITKTFEVNIL CCCCHHHCEEEEEEC	57.80	22368423
223	Phosphorylation	LCPVFVNTGFTKNPS CCEEEECCCCCCCCC	28.50	21060948
230	Phosphorylation	TGFTKNPSTRLWPVL CCCCCCCCCCCCCEE	35.24	21060948

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DHB13_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DHB13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DHB13_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ECI2_HUMAN	ECI2	physical	26186194
TSN10_HUMAN	TSPAN10	physical	26186194
TSN10_HUMAN	TSPAN10	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.