DFFA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DFFA_MOUSE
• UniProt AC: O54786
• Protein Name: DNA fragmentation factor subunit alpha
• Gene Name: Dffa
• Organism: Mus musculus (Mouse).
• Sequence Length: 331
• Subcellular Localization: Cytoplasm.
• Protein Description: Inhibitor of the caspase-activated DNase (DFF40)..
• Protein Sequence: MELSRGASAPDPDDVRPLKPCLLRRNHSRDQHGVAASSLEELRSKACELLAIDKSLTPITLVLAEDGTIVDDDDYFLCLPSNTKFVALACNEKWIYNDSDGGTAWVSQESFEADEPDSRAGVKWKNVARQLKEDLSSIILLSEEDLQALIDIPCAELAQELCQSCATVQGLQSTLQQVLDQREEARQSKQLLELYLQALEKEGNILSNQKESKAALSEELDAVDTGVGREMASEVLLRSQILTTLKEKPAPELSLSSQDLESVSKEDPKALAVALSWDIRKAETVQQACTTELALRLQQVQSLHSLRNLSARRSPLPGEPQRPKRAKRDSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MELSRGAS -------CCCCCCCC	12.03	-
8	Phosphorylation	MELSRGASAPDPDDV CCCCCCCCCCCHHHC	43.06	25266776
28	Phosphorylation	CLLRRNHSRDQHGVA HHHCCCCCCCCCCCC	40.89	30635358
37	Phosphorylation	DQHGVAASSLEELRS CCCCCCCHHHHHHHH	26.22	27742792
38	Phosphorylation	QHGVAASSLEELRSK CCCCCCHHHHHHHHH	34.76	29899451
45	Acetylation	SLEELRSKACELLAI HHHHHHHHHHHHHHH	51.09	23954790
96	Phosphorylation	ACNEKWIYNDSDGGT EECCCEEEECCCCCE	16.29	30635358
99	Phosphorylation	EKWIYNDSDGGTAWV CCEEEECCCCCEEEE	34.22	30635358
103	Phosphorylation	YNDSDGGTAWVSQES EECCCCCEEEECHHH	23.91	30635358
107	Phosphorylation	DGGTAWVSQESFEAD CCCEEEECHHHCCCC	19.96	26643407
110	Phosphorylation	TAWVSQESFEADEPD EEEECHHHCCCCCCC	22.28	26643407
118	Phosphorylation	FEADEPDSRAGVKWK CCCCCCCCCCCCCHH	34.44	30635358
217	Phosphorylation	KESKAALSEELDAVD HHHHHHHHHHHHHHH	25.05	28833060
243	Phosphorylation	LLRSQILTTLKEKPA HHHHHHHHHHHCCCC	31.54	-
256 (in isoform 2)	Phosphorylation	-	23.68	28464351
310	Phosphorylation	LHSLRNLSARRSPLP HHHHHCHHCCCCCCC	24.23	27600695
314	Phosphorylation	RNLSARRSPLPGEPQ HCHHCCCCCCCCCCC	25.82	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DFFA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DFFA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DFFA_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DFFB_MOUSE	Dffb	physical	9422506

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-314, AND MASSSPECTROMETRY.
PubMed: 19367708