| UniProt ID | DEND_HUMAN | |
|---|---|---|
| UniProt AC | O94850 | |
| Protein Name | Dendrin | |
| Gene Name | DDN | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 711 | |
| Subcellular Localization |
Cell projection, dendritic spine membrane Peripheral membrane protein. Cytoplasm. Endoplasmic reticulum membrane Peripheral membrane protein Cytoplasmic side. Perikaryon. Nucleus. Enriched at the cytoplasmic insertion of the slit diaphragm into th |
|
| Protein Description | Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity).. | |
| Protein Sequence | MLDGPLFSEGPDSPRELQDEESGSCLWVQKSKLLVIEVKTISCHYSRRAPSRQPMDFQASHWARGFQNRTCGPRPGSPQPPPRRPWASRVLQEATNWRAGPLAEVRAREQEKRKAASQEREAKETERKRRKAGGARRSPPGRPRPEPRNAPRVAQLAGLPAPLRPERLAPVGRAPRPSAQPQSDPGSAWAGPWGGRRPGPPSYEAHLLLRGSAGTAPRRRWDRPPPYVAPPSYEGPHRTLGTKRGPGNSQVPTSSAPAATPARTDGGRTKKRLDPRIYRDVLGAWGLRQGQGLLGGSPGCGAARARPEPGKGVVEKSLGLAAADLNSGSDSHPQAKATGSAGTEIAPAGSATAAPCAPHPAPRSRHHLKGSREGKEGEQIWFPKCWIPSPKKQPPRHSQTLPRPWAPGGTGWRESLGLGEGAGPETLEGWKATRRAHTLPRSSQGLSRGEGVFVIDATCVVIRSQYVPTPRTQQVQLLPSGVTRVVGDSPSQSKPGKEEGEGATVFPSPCQKRLSSSRLLHQPGGGRGGEAEGGRPGDSTLEERTFRILGLPAPEVNLRDAPTQPGSPEHQALGPAASGAQGRAEGSEVAVVQRRAGRGWARTPGPYAGALREAVSRIRRHTAPDSDTDEAEELSVHSGSSDGSDTEAPGASWRNERTLPEVGNSSPEEDGKTAELSDSVGEILDVISQTEEVLFGVRDIRGTQQGNRKRQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 30 | Ubiquitination | GSCLWVQKSKLLVIE CCEEEEECCEEEEEE | 39.68 | 29967540 | |
| 77 | Phosphorylation | TCGPRPGSPQPPPRR CCCCCCCCCCCCCCC | 24.04 | 28165663 | |
| 128 | Acetylation | EAKETERKRRKAGGA HHHHHHHHHHHHCCC | 50.77 | 7370147 | |
| 215 | Phosphorylation | LLRGSAGTAPRRRWD HHCCCCCCCCCCCCC | 32.95 | 22964224 | |
| 253 | Phosphorylation | PGNSQVPTSSAPAAT CCCCCCCCCCCCCCC | 36.14 | - | |
| 254 | Phosphorylation | GNSQVPTSSAPAATP CCCCCCCCCCCCCCC | 20.59 | - | |
| 260 | Phosphorylation | TSSAPAATPARTDGG CCCCCCCCCCCCCCC | 21.42 | - | |
| 271 | Methylation | TDGGRTKKRLDPRIY CCCCCCCCCCCHHHH | 58.54 | - | |
| 340 | Phosphorylation | PQAKATGSAGTEIAP CCCCCCCCCCCEECC | 21.12 | 28857561 | |
| 375 | Ubiquitination | LKGSREGKEGEQIWF CCCCCCCCCCCEEEC | 58.77 | 29967540 | |
| 389 | Phosphorylation | FPKCWIPSPKKQPPR CCCCCCCCCCCCCCC | 39.97 | - | |
| 398 | Phosphorylation | KKQPPRHSQTLPRPW CCCCCCCCCCCCCCC | 26.58 | 26437602 | |
| 400 | Phosphorylation | QPPRHSQTLPRPWAP CCCCCCCCCCCCCCC | 41.57 | 24719451 | |
| 504 | Phosphorylation | KEEGEGATVFPSPCQ CCCCCCCCCCCCHHH | 33.27 | 25627689 | |
| 508 | Phosphorylation | EGATVFPSPCQKRLS CCCCCCCCHHHHHCC | 27.18 | 21815630 | |
| 513 | Phosphorylation | FPSPCQKRLSSSRLL CCCHHHHHCCCCCCC | 17.58 | 18220336 | |
| 563 | Phosphorylation | VNLRDAPTQPGSPEH CCCCCCCCCCCCHHH | 49.47 | 20873877 | |
| 567 | Phosphorylation | DAPTQPGSPEHQALG CCCCCCCCHHHHCCC | 33.52 | 21082442 | |
| 603 | Phosphorylation | AGRGWARTPGPYAGA CCCCCCCCCCHHHHH | 25.50 | 28555341 | |
| 665 | Phosphorylation | TLPEVGNSSPEEDGK CCCCCCCCCCCCCCC | 41.14 | 28857561 | |
| 666 | Phosphorylation | LPEVGNSSPEEDGKT CCCCCCCCCCCCCCC | 40.09 | 28857561 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DEND_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DEND_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DEND_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MAGI1_HUMAN | MAGI1 | physical | 16464232 | |
| ACTN1_HUMAN | ACTN1 | physical | 16464232 | |
| SH3K1_HUMAN | SH3KBP1 | physical | 16751601 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-567, AND MASSSPECTROMETRY. | |
