DEN6B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DEN6B_HUMAN
• UniProt AC: Q8NEG7
• Protein Name: Protein DENND6B
• Gene Name: DENND6B
• Organism: Homo sapiens (Human).
• Sequence Length: 585
• Subcellular Localization: Recycling endosome . Cytoplasm .
• Protein Description: Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35..
• Protein Sequence: MDALLGTGPRRARGCLGAAGPTSSGRAARTPAAPWARFSAWLECVCVVTFDLELGQALELVYPNDFRLTDKEKSSICYLSFPDSHSGCLGDTQFSFRMRQCGGQRSPWHADDRHYNSRAPVALQREPAHYFGYVYFRQVKDSSVKRGYFQKSLVLVSRLPFVRLFQALLSLIAPEYFDKLAPCLEAVCSEIDQWPAPAPGQTLNLPVMGVVVQVRIPSRVDKSESSPPKQFDQENLLPAPVVLASVHELDLFRCFRPVLTHMQTLWELMLLGEPLLVLAPSPDVSSEMVLALTSCLQPLRFCCDFRPYFTIHDSEFKEFTTRTQAPPNVVLGVTNPFFIKTLQHWPHILRVGEPKMSGDLPKQVKLKKPSRLKTLDTKPGLYTAYTAHLHRDKALLKRLLKGVQKKRPSDVQSALLRRHLLELTQSFIIPLEHYMASLMPLQKSITPWKTPPQIQPFSQDDFLRSLEHAGPQLTCILKGDWLGLYRRFFKSPHFDGWYRQRHKEMALKLEALHLEAICEANIETWMKDKSEVEVVDLVLKLREKLVRAQGHQLPVKEATLQRAQLYIETVIGSLPKDLQAVLCPP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	CLGAAGPTSSGRAAR CCCCCCCCCCCHHCC		27251275
23	Phosphorylation	LGAAGPTSSGRAART CCCCCCCCCCHHCCC		27251275
24	Phosphorylation	GAAGPTSSGRAARTP CCCCCCCCCHHCCCC		27251275
74	Phosphorylation	RLTDKEKSSICYLSF CCCCCCCCCCEEEEC		-
95	Phosphorylation	CLGDTQFSFRMRQCG CCCCCEEEEEEEECC		24719451
115	Phosphorylation	WHADDRHYNSRAPVA CCCCCCCCCCCCCCC		24719451
117	Phosphorylation	ADDRHYNSRAPVALQ CCCCCCCCCCCCCCC		24719451
218	Phosphorylation	VVQVRIPSRVDKSES EEEEECCCCCCCCCC		30266825
223	Phosphorylation	IPSRVDKSESSPPKQ CCCCCCCCCCCCCCC		30266825
225	Phosphorylation	SRVDKSESSPPKQFD CCCCCCCCCCCCCCC		30266825
226	Phosphorylation	RVDKSESSPPKQFDQ CCCCCCCCCCCCCCH		30266825
378	Ubiquitination	RLKTLDTKPGLYTAY CCCCCCCCCCHHHHH		29967540
409	Phosphorylation	GVQKKRPSDVQSALL HHHHCCCHHHHHHHH		-
413	Phosphorylation	KRPSDVQSALLRRHL CCCHHHHHHHHHHHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DEN6B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DEN6B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DEN6B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.