DEN5B_HUMAN - dbPTM
DEN5B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DEN5B_HUMAN
UniProt AC Q6ZUT9
Protein Name DENN domain-containing protein 5B
Gene Name DENND5B
Organism Homo sapiens (Human).
Sequence Length 1274
Subcellular Localization Membrane
Single-pass membrane protein .
Protein Description Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form..
Protein Sequence MSGSCAAPGPGSGSSPAACRFAHYFVLCGIDADSGLEPDELAGENFDQSPLRRTFKSKVLAHYPQNIEWNPFDQDAVNMLCMPKGLSFRTQTDNKDPQFHSFIITREDGSRTYGFVLTFYEEVTSKQICTAMQTLYQMHNAEHYSSVYASSSCSMDSLASSLDEGDTTSLLKLQRYNSYDISRDTLYVSKSICLITPLPFMQACKKFLIQLYKAVTSQQPPPLPLESYIHNILYEVPLPPPGRSLKFYGVYEPVICQRPGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNHFIELPEEFPQFPNKVDFIQELSEVLVQFGIPPEGSLHCSESTSKLKNMVLKDLVNDKKNGNVCTNNISMYELLKGNETIARLQALAKRTGVAVEKMDLSASLGEKDKDLKLHCEEAELRDYQLNVQLREVFANRFTQMFADYEAFVIQTAQDMESWLTNREQMQNFDKASFLSDQPEPYLPFLSRFIETQMFATFIDNKIMSQWEEKDPLLRVFDTRIDKIRLYNVRAPTLRTSIYQKCSTLKEAAQSIEQRLMKMDHTAIHPHLLDMKIGQGKYEQGFFPKLQSDVLATGPTSNNRWVSRSATAQRRKERLRQHSEHVGLDNDLREKYMQEARSLGKNLRQPKLSDLSPAVIAQTNCKFVEGLLKECRMKTKRMLVEKMGHEAVELGHGEANITGLEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLIQFQDREEKQEHLAESPVALGPERRKSDSGVMLPTLRVSLIQDMRHIQNMSEIKTDVGRARAWIRLSLEKKLLSQHLKQLLSNQPLTKKLYKRYAFLRCEEEREQFLYHLLSLNAVDYFCFTSVFTTIMIPYRSVIIPIKKLSNAIITSNPWICVSGELGDTGVMQIPKNLLEMTFECQNLGKLTTVQIGHDNSGLLAKWLVDCVMVRNEITGHTYRFPCGRWLGKGIDDGSLERILIGELMTSASDEDLVKQCRTPPQQKSPTTARRLSITSLTGKNNKPNAGQIQEGIGEAVNNIVKHFHKPEKERGSLTVLLCGENGLVAALEQVFHHGFKSARIFHKNVFIWDFIEKVVAYFETTDQILDNEDDVLIQKSSCKTFCHYVNAINTAPRNIGKDGKFQILVCLGTRDRLLPQWIPLLAECPAITRMYEESALLRDRMTVNSLIRILQTIQDFTIVLEGSLIKGVDV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSGSCAAPG
------CCCCCCCCC		51.2022814378
42 (in isoform 2)Phosphorylation-22.6222210691
49PhosphorylationAGENFDQSPLRRTFK
CCCCCCCCHHHHHHH		27.96-
49 (in isoform 2)Phosphorylation-27.9622210691
56 (in isoform 4)Phosphorylation-49.0720068231
69 (in isoform 2)Phosphorylation-17.6320068231
92PhosphorylationGLSFRTQTDNKDPQF
CCCEEECCCCCCCCC		40.7130243723
112PhosphorylationTREDGSRTYGFVLTF
EECCCCEEEEEEEEE		29.6923663014
113PhosphorylationREDGSRTYGFVLTFY
ECCCCEEEEEEEEEE		13.8823663014
118PhosphorylationRTYGFVLTFYEEVTS
EEEEEEEEEEEHHCH		20.9023663014
120PhosphorylationYGFVLTFYEEVTSKQ
EEEEEEEEEHHCHHH		13.1223663014
124PhosphorylationLTFYEEVTSKQICTA
EEEEEHHCHHHHHHH		33.2223663014
125PhosphorylationTFYEEVTSKQICTAM
EEEEHHCHHHHHHHH		27.9523663014
169PhosphorylationLDEGDTTSLLKLQRY
CCCCCCHHHHHHHHH		33.5224719451
176PhosphorylationSLLKLQRYNSYDISR
HHHHHHHHCCCCCCC		8.7626657352
178PhosphorylationLKLQRYNSYDISRDT
HHHHHHCCCCCCCCC		18.4325159151
179PhosphorylationKLQRYNSYDISRDTL
HHHHHCCCCCCCCCE		17.4130576142
182PhosphorylationRYNSYDISRDTLYVS
HHCCCCCCCCCEEEC		22.6223312004
185PhosphorylationSYDISRDTLYVSKSI
CCCCCCCCEEECCEE		20.9123312004
187PhosphorylationDISRDTLYVSKSICL
CCCCCCEEECCEEEE		12.5518083107
189PhosphorylationSRDTLYVSKSICLIT
CCCCEEECCEEEEEC		13.7123312004
216PhosphorylationIQLYKAVTSQQPPPL
HHHHHHHHCCCCCCC		26.1922210691
217PhosphorylationQLYKAVTSQQPPPLP
HHHHHHHCCCCCCCC		21.8822210691
354PhosphorylationGLQSKEGTDRSKLEL
CCCCCCCCCHHHCCC		29.36-
358UbiquitinationKEGTDRSKLELPQEA
CCCCCHHHCCCCCCC		47.04-
421UbiquitinationSESTSKLKNMVLKDL
CCCHHHHHHCHHHHH		46.89-
426UbiquitinationKLKNMVLKDLVNDKK
HHHHCHHHHHHCCCC		37.29-
443PhosphorylationNVCTNNISMYELLKG
CCCCCCCCHHHHHCC		19.89-
445PhosphorylationCTNNISMYELLKGNE
CCCCCCHHHHHCCCH		9.1628674419
462UbiquitinationARLQALAKRTGVAVE
HHHHHHHHHHCCEEE		51.87-
470UbiquitinationRTGVAVEKMDLSASL
HHCCEEEECCCCHHC		30.99-
474PhosphorylationAVEKMDLSASLGEKD
EEEECCCCHHCCCCC		16.1429396449
476PhosphorylationEKMDLSASLGEKDKD
EECCCCHHCCCCCCC		33.2723403867
480UbiquitinationLSASLGEKDKDLKLH
CCHHCCCCCCCHHHE		69.18-
496PhosphorylationEEAELRDYQLNVQLR
HHHHHHHHHHHHHHH		14.4120068231
543 (in isoform 1)Ubiquitination-41.6221906983
543UbiquitinationEQMQNFDKASFLSDQ
HHHHCCCHHHHCCCC		41.62-
545PhosphorylationMQNFDKASFLSDQPE
HHCCCHHHHCCCCCC		32.2528985074
565 (in isoform 4)Ubiquitination-16.5321906983
578 (in isoform 2)Ubiquitination-33.9321906983
613UbiquitinationLRTSIYQKCSTLKEA
HHHHHHHHHHHHHHH		17.12-
660PhosphorylationGFFPKLQSDVLATGP
CCCCCCCCCEECCCC		39.8725690035
691PhosphorylationKERLRQHSEHVGLDN
HHHHHHHHHHCCCCH		22.5128555341
724PhosphorylationQPKLSDLSPAVIAQT
CCCHHHCCHHHHHHC		18.7925159151
815UbiquitinationQFQDREEKQEHLAES
HCCCHHHHHHHHHHC		57.12-
822PhosphorylationKQEHLAESPVALGPE
HHHHHHHCCCCCCCC		21.0430266825
833PhosphorylationLGPERRKSDSGVMLP
CCCCCCCCCCCCCCC		34.8923927012
835PhosphorylationPERRKSDSGVMLPTL
CCCCCCCCCCCCCHH		40.1423927012
841PhosphorylationDSGVMLPTLRVSLIQ
CCCCCCCHHHHHHHH		24.2023403867
877UbiquitinationIRLSLEKKLLSQHLK
HHHHHHHHHHHHHHH		45.33-
888PhosphorylationQHLKQLLSNQPLTKK
HHHHHHHCCCCHHHH		41.8529978859
893PhosphorylationLLSNQPLTKKLYKRY
HHCCCCHHHHHHHHH		32.5829978859
894UbiquitinationLSNQPLTKKLYKRYA
HCCCCHHHHHHHHHH		48.76-
1021PhosphorylationRNEITGHTYRFPCGR
CCCCCCCEEEECCCC		20.1020068231
1022PhosphorylationNEITGHTYRFPCGRW
CCCCCCEEEECCCCC		12.4629759185
1038PhosphorylationGKGIDDGSLERILIG
CCCCCCCCCHHHHHH		33.7726091039
1062PhosphorylationDLVKQCRTPPQQKSP
HHHHHCCCCCCCCCC		47.1223403867
1068PhosphorylationRTPPQQKSPTTARRL
CCCCCCCCCCCHHHH		24.1223403867
1070PhosphorylationPPQQKSPTTARRLSI
CCCCCCCCCHHHHEE		39.9323882029
1071PhosphorylationPQQKSPTTARRLSIT
CCCCCCCCHHHHEEE		22.8823882029
1076PhosphorylationPTTARRLSITSLTGK
CCCHHHHEEEECCCC		23.2426846344
1078PhosphorylationTARRLSITSLTGKNN
CHHHHEEEECCCCCC		17.8222167270
1079PhosphorylationARRLSITSLTGKNNK
HHHHEEEECCCCCCC		23.4322167270
1081PhosphorylationRLSITSLTGKNNKPN
HHEEEECCCCCCCCC		45.9726846344
1267PhosphorylationFTIVLEGSLIKGVDV
CEEEEECCEECCCCC		19.9724719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DEN5B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DEN5B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DEN5B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NTM1A_HUMANNTMT1physical
22939629
HSF1_HUMANHSF1physical
22939629
GRB10_HUMANGRB10physical
22939629
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DEN5B_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1076, AND MASSSPECTROMETRY.
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1076, AND MASSSPECTROMETRY.

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