DEN2C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DEN2C_HUMAN
• UniProt AC: Q68D51
• Protein Name: DENN domain-containing protein 2C
• Gene Name: DENND2C
• Organism: Homo sapiens (Human).
• Sequence Length: 928
• Protein Description: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form..
• Protein Sequence: MDVGFSRTTVQTLSRSHCKNIKQKISQWEGRANGISNPEKWCPKDFGVRYNCHQEIRLKKNPIAERKSKNLDVTSRENVGLDINENTKSHDQSENENKKHEYDDTHFFKNESESNWVCSRVKEIESCKEDVLDPETSLPPGNFYTSQILWKKIEALPPDKLLNLALEHCDSSEKELNFRVLDSSYGITKSLENIYSEPEGQECGPSINPLPKPRRTFRYLSESGVTPYKERNCDKKYCENNSCAQSSLASSQEPEPKKYGGKIRGRSKRKSFEFEDIQHFRNRNSQTIREELGRNSGSALYYTQSEDNIYEDIIYPTKENPYEDIPVQPLPMWRSPSAWKLPPAKSAFKAPKLPPKPQFLHRKTMEVKNSQAYLRSKLTKDTTLPVTLTEWKLFRAGEVANTKRKNLPRLVLKIDDIFESKRGKKKVKLHSYTGKELPPTKGETSGNESDAEYLPKNRHKRLAQLQPSSKRNPHYQTLERDLIELQEQQLFELFVVVSLQKKPSGISYIPQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCFPDSKDWMPTSELKSETFSFVLTGEDGSRWFGYCKKLLPVGKGKRLPEVYCMVSRLGCFNLFSKILDEVEKRREMSPALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLFKCLSVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILPPKLQAALMQILEERNEILTQEQNFSQDVTLNSLVSEAFVRFFVELVGHYSLNMTVTERGERVFQREPFRKSHTSRSVRHFLDLFMETQMFAGFIQDRELRKSGVKGLFEIRAIQYLETIPESEPSGMNRILRSLGSKMKFLQKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	FSRTTVQTLSRSHCK CCHHHHHHHCHHHHH	23.51	27535140
36	Phosphorylation	EGRANGISNPEKWCP HCHHCCCCCHHHCCC	47.97	30576142
50	Phosphorylation	PKDFGVRYNCHQEIR CCCCCCCCCCCCHHH	21.53	25690035
74	Phosphorylation	KSKNLDVTSRENVGL HCCCCCCCCHHHCCC	23.02	28060719
75	Phosphorylation	SKNLDVTSRENVGLD CCCCCCCCHHHCCCC	37.13	28060719
87	Phosphorylation	GLDINENTKSHDQSE CCCCCCCCCCCCCCC	27.96	28060719
102	Phosphorylation	NENKKHEYDDTHFFK CCCCCCCCCCCCCCC	20.88	27642862
136	Phosphorylation	EDVLDPETSLPPGNF CCCCCCCCCCCCCCC	40.74	22468782
146	Phosphorylation	PPGNFYTSQILWKKI CCCCCHHHHHHHHHH	12.12	22468782
171	O-linked_Glycosylation	LALEHCDSSEKELNF HHHHHCCCCCCCCCE	45.88	30620550
183	Phosphorylation	LNFRVLDSSYGITKS CCEEEEECCCCCCHH	22.69	28152594
184	Phosphorylation	NFRVLDSSYGITKSL CEEEEECCCCCCHHH	27.35	29978859
185	Phosphorylation	FRVLDSSYGITKSLE EEEEECCCCCCHHHH	19.25	28152594
188	Phosphorylation	LDSSYGITKSLENIY EECCCCCCHHHHHHH	15.37	28152594
190	Phosphorylation	SSYGITKSLENIYSE CCCCCCHHHHHHHCC	32.06	25849741
195	Phosphorylation	TKSLENIYSEPEGQE CHHHHHHHCCCCCCC	20.68	21082442
196	Phosphorylation	KSLENIYSEPEGQEC HHHHHHHCCCCCCCC	42.76	30266825
216	Phosphorylation	PLPKPRRTFRYLSES CCCCCCCCHHHHHHC	17.47	29759185
219	Phosphorylation	KPRRTFRYLSESGVT CCCCCHHHHHHCCCC	15.47	28060719
221	Phosphorylation	RRTFRYLSESGVTPY CCCHHHHHHCCCCCC	22.30	29970186
223	Phosphorylation	TFRYLSESGVTPYKE CHHHHHHCCCCCCHH	34.88	29978859
226	Phosphorylation	YLSESGVTPYKERNC HHHHCCCCCCHHCCC	25.15	29759185
228	Phosphorylation	SESGVTPYKERNCDK HHCCCCCCHHCCCCH	19.00	29759185
237	Phosphorylation	ERNCDKKYCENNSCA HCCCCHHHHCCCCCC	15.67	29978859
242	Phosphorylation	KKYCENNSCAQSSLA HHHHCCCCCCCHHHC	23.55	29978859
246	Phosphorylation	ENNSCAQSSLASSQE CCCCCCCHHHCCCCC	14.59	29978859
247	Phosphorylation	NNSCAQSSLASSQEP CCCCCCHHHCCCCCC	18.84	29978859
262	Ubiquitination	EPKKYGGKIRGRSKR CCCCCCCCCCCCCCC	25.52	-
267	Phosphorylation	GGKIRGRSKRKSFEF CCCCCCCCCCCCCCH	39.37	24719451
271	Phosphorylation	RGRSKRKSFEFEDIQ CCCCCCCCCCHHHHH	33.76	25849741
285	Phosphorylation	QHFRNRNSQTIREEL HHHHHCCCHHHHHHH	26.01	23403867
287	Phosphorylation	FRNRNSQTIREELGR HHHCCCHHHHHHHHC	23.09	-
302	Phosphorylation	NSGSALYYTQSEDNI CCCCEEEEECCCCCE	10.11	28270605
303	Phosphorylation	SGSALYYTQSEDNIY CCCEEEEECCCCCEE	16.44	28270605
305	Phosphorylation	SALYYTQSEDNIYED CEEEEECCCCCEEEC	38.83	28270605
322	Phosphorylation	YPTKENPYEDIPVQP CCCCCCCCCCCCCCC	37.50	27642862
337	Phosphorylation	LPMWRSPSAWKLPPA CCCCCCCCCCCCCCC	48.27	28060719
370	O-linked_Glycosylation	KTMEVKNSQAYLRSK CEEEECCCHHHHHHH	15.52	30620550
402	Phosphorylation	RAGEVANTKRKNLPR HCCCHHCCCCCCCCH	23.61	28122231
444	Phosphorylation	LPPTKGETSGNESDA CCCCCCCCCCCHHHH	51.07	22777824
445	Phosphorylation	PPTKGETSGNESDAE CCCCCCCCCCHHHHH	35.01	29970186
449	Phosphorylation	GETSGNESDAEYLPK CCCCCCHHHHHHCCC	46.23	22777824
453	Phosphorylation	GNESDAEYLPKNRHK CCHHHHHHCCCHHHH	29.99	28060719
468	Phosphorylation	RLAQLQPSSKRNPHY HHHHCCCCCCCCCCH	35.21	29978859
469	Phosphorylation	LAQLQPSSKRNPHYQ HHHCCCCCCCCCCHH	42.17	29978859
477	Phosphorylation	KRNPHYQTLERDLIE CCCCCHHHHHHHHHH	24.34	28060719
504	Phosphorylation	VSLQKKPSGISYIPQ EECCCCCCCCCCCCH	58.60	25849741
507	Phosphorylation	QKKPSGISYIPQVIQ CCCCCCCCCCCHHHH	22.12	25849741
508	Phosphorylation	KKPSGISYIPQVIQQ CCCCCCCCCCHHHHH	18.07	23090842
524	Phosphorylation	PGKDDHGYKQSKDME CCCCCCCCCCCCCHH	11.48	23312004
604	Phosphorylation	LGCFNLFSKILDEVE HHHHHHHHHHHHHHH	23.19	24719451
677	Phosphorylation	KCLFKCLSVCHLIRV HHHHHHHHHHHHHHH	31.97	-
920	Phosphorylation	RILRSLGSKMKFLQK HHHHHHHHHHHHHHC	34.56	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DEN2C_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DEN2C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DEN2C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HID1_HUMAN	HID1	physical	28514442
RHG42_HUMAN	ARHGAP42	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.