DDRGK_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DDRGK_MOUSE
• UniProt AC: Q80WW9
• Protein Name: DDRGK domain-containing protein 1 {ECO:0000305}
• Gene Name: Ddrgk1 {ECO:0000312|MGI:MGI:1924256}
• Organism: Mus musculus (Mouse).
• Sequence Length: 315
• Subcellular Localization: Endoplasmic reticulum .
• Protein Description: Protein which interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. Through TRIP4 ufmylation may regulate nuclear receptors-mediated transcription. May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B (By similarity). May also play a role in the cellular response to endoplasmic reticulum stress. [PubMed: 21494687]
• Protein Sequence: MVGPWVYLVAAVLLIGLILFLTRSRGRAAAADGEPLHNEEERAGAGQVGRSLPQESEEQRTGSRPRRRRDLGSRLQAQRRAQRVAWEDGDENVGQTVIPAQEEEGIEKPAEVHPTGKIGAKKLRKLEEKQARKAQREAEEAEREERKRLESQREAEWKKEEERLRLKEEQKEEEERKAQEEQARREHEEYLKLKEAFVVEEEGVSETMTEEQSHSFLTEFINYIKKSKVVLLEDLAFQMGLRTQDAINRIQDLLTEGTLTGVIDDRGKFIYITPEELAAVANFIRQRGRVSITELAQASNSLISWGQDLPAQASA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Phosphorylation	GRSLPQESEEQRTGS CCCCCCCCHHHHCCC	40.98	27841257
73	Phosphorylation	RRRRDLGSRLQAQRR CHHHHHHHHHHHHHH	36.80	29514104
108	Ubiquitination	QEEEGIEKPAEVHPT CHHCCCCCCCCCCCC	47.83	22790023
151	Phosphorylation	EERKRLESQREAEWK HHHHHHHHHHHHHHH	38.85	25338131
190	Phosphorylation	ARREHEEYLKLKEAF HHHHHHHHHHHHHHE	13.22	25159016

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DDRGK_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
268	K	ubiquitylation	Ufmylated; conjugated to ubiquitin-like protein UFM1, probably at Lys-268 by UFL1.	21494687

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DDRGK_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ASCC1_MOUSE	Ascc1	physical	25219498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.