DDC_HUMAN - dbPTM
DDC_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DDC_HUMAN
UniProt AC P20711
Protein Name Aromatic-L-amino-acid decarboxylase
Gene Name DDC
Organism Homo sapiens (Human).
Sequence Length 480
Subcellular Localization
Protein Description Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine..
Protein Sequence MNASEFRRRGKEMVDYMANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDVEKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIMEKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMVATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MNASEFRR
-------CCHHHHHH		9.49-
4Phosphorylation----MNASEFRRRGK
----CCHHHHHHHHH		32.0628857561
52PhosphorylationAAPQEPDTFEDIIND
CCCCCCCCHHHHHHH		39.3725338102
147PhosphorylationGGGVIQGSASEATLV
CCCCCCCCCCHHHHH		16.5528857561
149PhosphorylationGVIQGSASEATLVAL
CCCCCCCCHHHHHHH		29.4828857561
152PhosphorylationQGSASEATLVALLAA
CCCCCHHHHHHHHHH		20.0828857561
171PhosphorylationIHRLQAASPELTQAA
HHHHHHCCHHHHHHH		23.1728857561
193PhosphorylationYSSDQAHSSVERAGL
HCCCCCCCHHHHHCC		38.8128857561
194PhosphorylationSSDQAHSSVERAGLI
CCCCCCCHHHHHCCC		20.3828857561
220PhosphorylationGNFAMRASALQEALE
CCHHHHHHHHHHHHH		21.1029759185
303N6-(pyridoxal phosphate)lysineSFNFNPHKWLLVNFD
HCCCCCCCEEEEEEE		40.57-
303OtherSFNFNPHKWLLVNFD
HCCCCCCCEEEEEEE		40.5722143761
332 (in isoform 2)Phosphorylation-21.0921964256
336PhosphorylationDPTYLKHSHQDSGLI
CCCHHCCCCCCCCCC		22.6628857561
340PhosphorylationLKHSHQDSGLITDYR
HCCCCCCCCCCCCCC		29.0028857561
457PhosphorylationICSRTVESAHVQRAW
ECCCCHHHHHHHHHH		21.2428857561
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DDC_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DDC_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DDC_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TF65_HUMANRELAphysical
21988832
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
608643Aromatic L-amino-acid decarboxylase deficiency (AADCD)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00915Amantadine
DB00190Carbidopa
DB00260Cycloserine
DB06262Droxidopa
DB00875Flupentixol
DB01235L-DOPA
DB00150L-Tryptophan
DB00968Methyldopa
Regulatory Network of DDC_HUMAN

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Related Literatures of Post-Translational Modification

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