dbPTM

DCR1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DCR1A_HUMAN
UniProt AC	Q6PJP8
Protein Name	DNA cross-link repair 1A protein
Gene Name	DCLRE1A
Organism	Homo sapiens (Human).
Sequence Length	1040
Subcellular Localization	Nucleus . In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation
Protein Description	May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons..
Protein Sequence	MLEDISEEDIWEYKSKRKPKRVDPNNGSKNILKSVEKATDGKYQSKRSRNRKRAAEAKEVKDHEVPLGNAGCQTSVASSQNSSCGDGIQQTQDKETTPGKLCRTQKSQHVSPKIRPVYDGYCPNCQMPFSSLIGQTPRWHVFECLDSPPRSETECPDGLLCTSTIPFHYKRYTHFLLAQSRAGDHPFSSPSPASGGSFSETKSGVLCSLEERWSSYQNQTDNSVSNDPLLMTQYFKKSPSLTEASEKISTHIQTSQQALQFTDFVENDKLVGVALRLANNSEHINLPLPENDFSDCEISYSPLQSDEDTHDIDEKPDDSQEQLFFTESSKDGSLEEDDDSCGFFKKRHGPLLKDQDESCPKVNSFLTRDKYDEGLYRFNSLNDLSQPISQNNESTLPYDLACTGGDFVLFPPALAGKLAASVHQATKAKPDEPEFHSAQSNKQKQVIEESSVYNQVSLPLVKSLMLKPFESQVEGYLSSQPTQNTIRKLSSENLNAKNNTNSACFCRKALEGVPVGKATILNTENLSSTPAPKYLKILPSGLKYNARHPSTKVMKQMDIGVYFGLPPKRKEEKLLGESALEGINLNPVPSPNQKRSSQCKRKAEKSLSDLEFDASTLHESQLSVELSSERSQRQKKRCRKSNSLQEGACQKRSDHLINTESEAVNLSKVKVFTKSAHGGLQRGNKKIPESSNVGGSRKKTCPFYKKIPGTGFTVDAFQYGVVEGCTAYFLTHFHSDHYAGLSKHFTFPVYCSEITGNLLKNKLHVQEQYIHPLPLDTECIVNGVKVVLLDANHCPGAVMILFYLPNGTVILHTGDFRADPSMERSLLADQKVHMLYLDTTYCSPEYTFPSQQEVIRFAINTAFEAVTLNPHALVVCGTYSIGKEKVFLAIADVLGSKVGMSQEKYKTLQCLNIPEINSLITTDMCSSLVHLLPMMQINFKGLQSHLKKCGGKYNQILAFRPTGWTHSNKFTRIADVIPQTKGNISIYGIPYSEHSSYLEMKRFVQWLKPQKIIPTVNVGTWKSRSTMEKYFREWKLEAGY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MLEDISEEDIWEY --CCCCCCHHHHHHH	47.45	28348404
28	Phosphorylation	RVDPNNGSKNILKSV CCCCCCCCCHHHHHH	25.34	26074081
29	Acetylation	VDPNNGSKNILKSVE CCCCCCCCHHHHHHH	49.78	7663019
34	Phosphorylation	GSKNILKSVEKATDG CCCHHHHHHHHHHCC	31.87	26074081
39	Phosphorylation	LKSVEKATDGKYQSK HHHHHHHHCCCCCCH	57.25	26074081
42	Acetylation	VEKATDGKYQSKRSR HHHHHCCCCCCHHHH	42.82	7663031
43	Phosphorylation	EKATDGKYQSKRSRN HHHHCCCCCCHHHHH	24.45	26074081
45	Phosphorylation	ATDGKYQSKRSRNRK HHCCCCCCHHHHHHH	27.26	26074081
83	Phosphorylation	VASSQNSSCGDGIQQ HHCCCCCCCCCCCCC	29.66	28985074
104	Phosphorylation	TPGKLCRTQKSQHVS CCCCCCCCCCCCCCC	39.08	26657352
107	Phosphorylation	KLCRTQKSQHVSPKI CCCCCCCCCCCCCCC	18.72	26657352
111	Phosphorylation	TQKSQHVSPKIRPVY CCCCCCCCCCCCCCC	20.53	24719451
189	Phosphorylation	AGDHPFSSPSPASGG CCCCCCCCCCCCCCC	29.76	23186163
191	Phosphorylation	DHPFSSPSPASGGSF CCCCCCCCCCCCCCC	34.74	23186163
202	Ubiquitination	GGSFSETKSGVLCSL CCCCCCCCCCEEEEH	40.95	32015554
202	Sumoylation	GGSFSETKSGVLCSL CCCCCCCCCCEEEEH	40.95	28112733
208	Phosphorylation	TKSGVLCSLEERWSS CCCCEEEEHHHHHHH	34.35	21815630
214	Phosphorylation	CSLEERWSSYQNQTD EEHHHHHHHHCCCCC	25.95	25072903
215	Phosphorylation	SLEERWSSYQNQTDN EHHHHHHHHCCCCCC	24.63	25072903
216	Phosphorylation	LEERWSSYQNQTDNS HHHHHHHHCCCCCCC	13.13	25072903
220	Phosphorylation	WSSYQNQTDNSVSND HHHHCCCCCCCCCCC	44.70	25072903
223	Phosphorylation	YQNQTDNSVSNDPLL HCCCCCCCCCCCCCH	29.72	25072903
225	Phosphorylation	NQTDNSVSNDPLLMT CCCCCCCCCCCCHHH	35.02	25072903
232	Phosphorylation	SNDPLLMTQYFKKSP CCCCCHHHHHHHCCC	21.78	26074081
234	Phosphorylation	DPLLMTQYFKKSPSL CCCHHHHHHHCCCCH	14.27	26074081
236	Sumoylation	LLMTQYFKKSPSLTE CHHHHHHHCCCCHHH	47.62	28112733
238	Phosphorylation	MTQYFKKSPSLTEAS HHHHHHCCCCHHHHH	21.95	23401153
240	Phosphorylation	QYFKKSPSLTEASEK HHHHCCCCHHHHHHH	55.82	30576142
242	Phosphorylation	FKKSPSLTEASEKIS HHCCCCHHHHHHHHH	33.57	26074081
245	Phosphorylation	SPSLTEASEKISTHI CCCHHHHHHHHHHHH	32.94	26074081
254	Phosphorylation	KISTHIQTSQQALQF HHHHHHHHHHHHHHC	28.09	25627689
255	Phosphorylation	ISTHIQTSQQALQFT HHHHHHHHHHHHHCC	12.15	30576142
269	Sumoylation	TDFVENDKLVGVALR CHHHCCCHHHHEEEE	57.57	28112733
333	Phosphorylation	TESSKDGSLEEDDDS EECCCCCCCCCCCCC	42.62	20873877
340	Phosphorylation	SLEEDDDSCGFFKKR CCCCCCCCCCCCHHH	24.12	25159151
353	Sumoylation	KRHGPLLKDQDESCP HHCCCCCCCCCCCCC	62.11	28112733
353	Ubiquitination	KRHGPLLKDQDESCP HHCCCCCCCCCCCCC	62.11	29967540
358	Phosphorylation	LLKDQDESCPKVNSF CCCCCCCCCCCCCCC	43.97	28985074
361	Sumoylation	DQDESCPKVNSFLTR CCCCCCCCCCCCCCC	59.38	28112733
361	Ubiquitination	DQDESCPKVNSFLTR CCCCCCCCCCCCCCC	59.38	29967540
364	Phosphorylation	ESCPKVNSFLTRDKY CCCCCCCCCCCCCCC	25.31	28555341
370	Ubiquitination	NSFLTRDKYDEGLYR CCCCCCCCCCCCCCC	51.84	29967540
380	Phosphorylation	EGLYRFNSLNDLSQP CCCCCCCCCCCCCCC	26.32	26074081
421	Phosphorylation	LAGKLAASVHQATKA HHHHHHHHHHHHHCC	17.96	27174698
426	Phosphorylation	AASVHQATKAKPDEP HHHHHHHHCCCCCCC	25.60	27174698
429	Sumoylation	VHQATKAKPDEPEFH HHHHHCCCCCCCCHH	55.33	28112733
457	Phosphorylation	SSVYNQVSLPLVKSL HCHHHHHCHHHHHHH	17.95	-
488	Sumoylation	PTQNTIRKLSSENLN CCHHHHHHHHHHCCC	49.20	28112733
488	Ubiquitination	PTQNTIRKLSSENLN CCHHHHHHHHHHCCC	49.20	29967540
490	Phosphorylation	QNTIRKLSSENLNAK HHHHHHHHHHCCCCC	38.34	25159151
491	Phosphorylation	NTIRKLSSENLNAKN HHHHHHHHHCCCCCC	40.72	29978859
508	Sumoylation	NSACFCRKALEGVPV CCCCHHHHHHCCCCC	59.51	28112733
508	Sumoylation	NSACFCRKALEGVPV CCCCHHHHHHCCCCC	59.51	-
508	Ubiquitination	NSACFCRKALEGVPV CCCCHHHHHHCCCCC	59.51	29967540
517	Ubiquitination	LEGVPVGKATILNTE HCCCCCCEEEEECCC	42.46	32015554
517	Sumoylation	LEGVPVGKATILNTE HCCCCCCEEEEECCC	42.46	28112733
527	Phosphorylation	ILNTENLSSTPAPKY EECCCCCCCCCCCCH	43.69	25627689
529	Phosphorylation	NTENLSSTPAPKYLK CCCCCCCCCCCCHHH	21.79	25159151
533	Sumoylation	LSSTPAPKYLKILPS CCCCCCCCHHHCCCC	66.38	28112733
536	Sumoylation	TPAPKYLKILPSGLK CCCCCHHHCCCCCCC	38.82	28112733
536	Ubiquitination	TPAPKYLKILPSGLK CCCCCHHHCCCCCCC	38.82	29967540
543	Ubiquitination	KILPSGLKYNARHPS HCCCCCCCCCCCCCC	39.73	29967540
543	Methylation	KILPSGLKYNARHPS HCCCCCCCCCCCCCC	39.73	-
578	Phosphorylation	EEKLLGESALEGINL HHHHHCCCHHCCCCC	36.03	30266825
590	Phosphorylation	INLNPVPSPNQKRSS CCCCCCCCCCHHCCH	36.40	30266825
606	Phosphorylation	CKRKAEKSLSDLEFD HHHHHHHHHHHCCCC	25.31	28985074
620	Phosphorylation	DASTLHESQLSVELS CHHHHCHHHHHHHHC	26.18	28985074
623	Phosphorylation	TLHESQLSVELSSER HHCHHHHHHHHCHHH	13.10	28985074
641	Phosphorylation	QKKRCRKSNSLQEGA HHHHHHHCCCCCCCH	16.58	25627689
643	Phosphorylation	KRCRKSNSLQEGACQ HHHHHCCCCCCCHHH	38.22	25627689
653	Phosphorylation	EGACQKRSDHLINTE CCHHHHHCCCCCCCH	36.10	-
659	Phosphorylation	RSDHLINTESEAVNL HCCCCCCCHHHCCCH	33.62	-
661	Phosphorylation	DHLINTESEAVNLSK CCCCCCHHHCCCHHH	28.90	-
667	Phosphorylation	ESEAVNLSKVKVFTK HHHCCCHHHCEEEEE	30.14	-
668	Sumoylation	SEAVNLSKVKVFTKS HHCCCHHHCEEEEEC	49.60	28112733
670	Sumoylation	AVNLSKVKVFTKSAH CCCHHHCEEEEECCC	35.05	28112733
674	Sumoylation	SKVKVFTKSAHGGLQ HHCEEEEECCCCCCC	33.89	28112733
674	Ubiquitination	SKVKVFTKSAHGGLQ HHCEEEEECCCCCCC	33.89	29967540
691	Phosphorylation	NKKIPESSNVGGSRK CCCCCCCCCCCCCCC	33.60	18669648
696	Phosphorylation	ESSNVGGSRKKTCPF CCCCCCCCCCCCCCC	34.69	-
704	Phosphorylation	RKKTCPFYKKIPGTG CCCCCCCCCCCCCCC	9.12	28509920
962	Phosphorylation	QILAFRPTGWTHSNK EEEEECCCCCCCCCC	40.89	24719451
1023	Phosphorylation	VNVGTWKSRSTMEKY CCCCCCCCHHHHHHH	24.03	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DCR1A_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DCR1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DCR1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
ATM_HUMAN	ATM	physical	18848520
PIAS1_HUMAN	PIAS1	physical	15572677

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DCR1A_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-590, AND MASSSPECTROMETRY.	19413330 [Abstract]