DCA10_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCA10_DROME
• UniProt AC: Q9VAT2
• Protein Name: DDB1- and CUL4-associated factor 10 homolog
• Gene Name: CG1523
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 621
• Protein Sequence: MERYLSRRESGFHIHRSDDNSLMRRIYSSMNMFNSYHANCWPTDAGRTGAIFNLEFNADGNVVVAATERKCVLVFDAITQKEIFKVPDAHTDSVNCIKFFDERLFATGSDDFTVALWDLRNMKQKLRVLHGHSNWVKNIEYSSKDKLLVSSGFDGSIFTWDINSQTEQGLISQRVFHASGLMRCRISPTGDKLVLCTSGGYIMIIHHLDLTTLHKDLCGFRPGIYRLMQLGEQYIPQAAKYDHVFSKRQKKNRVELVTDFPENNDAEMIMALQIHPHCCCMLTRNVSCDEQSEWTCIHDINEEPVRSEDEQDEVEPQPKRKRVSTTLASRSSLNESQDQDTVGLTPRQARRPLRVSSVQVFQLDNSGAGRGASDNPSVLTRSDSFIPDIWAAEVTVQERAIRQNRARVSNNHVSGYNFVYAISSGVLPLRQLGANSLMGSSTSPRPLTTPPPTESNQSSSSSSSSSSSSSSSSSSNNSDTTVRLEIGNRLRLRSFNSPVTTPTFKENGHSILVNAKKLLYYAAETNTKPGFIKEPGFSADGRVVCSPYGNGVRLFGYSEDCCDYPKCQAFEEVKSKPRKLVELAKITEHQDVVLCAKFSPREPLLVTGCNGGEVTWYRPNL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	RYLSRRESGFHIHRS HHHHCCCCCCEEECC	44.97	22817900
307	Phosphorylation	INEEPVRSEDEQDEV CCCCCCCCHHCCCCC	50.03	22817900
357	Phosphorylation	RRPLRVSSVQVFQLD CCCCEECEEEEEECC	17.45	21082442
494	Phosphorylation	GNRLRLRSFNSPVTT CCEEEEEECCCCCCC	33.11	22817900
497	Phosphorylation	LRLRSFNSPVTTPTF EEEEECCCCCCCCCC	20.80	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCA10_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCA10_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCA10_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAKM_DROME	mbt	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307; SER-494 ANDSER-497, AND MASS SPECTROMETRY.
PubMed: 18327897