DAF4_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DAF4_CAEEL
• UniProt AC: P50488
• Protein Name: Cell surface receptor daf-4
• Gene Name: daf-4
• Organism: Caenorhabditis elegans.
• Sequence Length: 744
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Involved in TGF-beta pathway. May be a receptor for daf-7. Controls the dauer/nondauer developmental decision in a range of environmental conditions. Regulates body size and male tail patterning. [PubMed: 10887089 Involved in regulating entry into quiescence triggered by satiety]
• Protein Sequence: MNQKGTVRLKALVLICLPLFLIATPVPVAVTEDDRQDRIESEAAEKEWANTLVSKVAQSNGTGTIKVSAPAKPTLRRMDNEEDEVISIECVYYDEMECEKSGDCEITKKTCYSEAHLKAVGCLAVFGLPTQEINSTEPYLKVDKPQYKSLGCMPYQHADSMNCENESSCRQGRSFRGGIGMCCCSTNNCNMPDLIEMVNPSLKKDSDNSALLWASTPSNMDLESLDKFPFYWIIIIALSVILCIALLILAYVGWKFQQNKKEEIKKQQKIKFDMEKTDALEAGNVPLVEPEEEMIEMVETPKELPITDFQLISKGRFGKVFKAQYTPDSGEKRLVAVKKLNEFQKASFLAEKRIFDELNEYPKWYKSIVEFVCAEKIGDEYWIVTEFHERLSLYELLKNNVISITSANRIIMSMIDGLQFLHDDRPYFFGHPKKPIIHRDIKSKNILVKSDMTTCIADFGLARIYSYDIEQSDLLGQVGTKRYMSPEMLEGATEFTPTAFKAMDVYSMGLVMWEVISRTKLHQTDEPPNYQMPFQVIGFDPTIGLMRNYVVSKKERPQWRDEIIKHEYMSLLKKVTEEMWDPEACARITAGCAFARVWNHIMSSPDSSEGYHSGSSMKNRGVDDVEQSEKPEGIEEMQHYHASSPSKRQHPSPNPFFDSCPPPPPIPVILENGGILQPDNAEPEPEELPDLPIVEKIYDIATNMLFSREELDLMNAQRQVEYEAGADTRASTPTPSGTFGTFTT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	N-linked_Glycosylation	VSKVAQSNGTGTIKV HHHHHHHCCCCEEEE	39.71	17761667
134	N-linked_Glycosylation	GLPTQEINSTEPYLK CCCCCCCCCCCCCCC	41.97	17761667
165	N-linked_Glycosylation	ADSMNCENESSCRQG HHHCCCCCHHHHCCC	57.56	-
644	Phosphorylation	MQHYHASSPSKRQHP HHHHCCCCCCCCCCC	33.70	21082442
732	Phosphorylation	GADTRASTPTPSGTF CCCCCCCCCCCCCCC	30.14	28854356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DAF4_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DAF4_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DAF4_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COL19_CAEEL	col-19	physical	14992718
ATPB_CAEEL	atp-2	physical	14992718
HSP90_CAEEL	daf-21	physical	14992718
DAXX_HUMAN	DAXX	physical	11483955

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Proteomics reveals N-linked glycoprotein diversity in Caenorhabditiselegans and suggests an atypical translocation mechanism for integralmembrane proteins.";
Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T.,Taoka M., Takahashi N., Isobe T.;
Mol. Cell. Proteomics 6:2100-2109(2007).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-60 AND ASN-134, AND MASSSPECTROMETRY.
PubMed: 17761667