DACH1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DACH1_MOUSE
• UniProt AC: Q9QYB2
• Protein Name: Dachshund homolog 1
• Gene Name: Dach1
• Organism: Mus musculus (Mouse).
• Sequence Length: 751
• Subcellular Localization: Nucleus.
• Protein Description: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1 (By similarity). Binds to chromatin DNA via its DACHbox-N domain..
• Protein Sequence: MAVPAALIPPTQLVPPQPPISTSASSSGTTTSTSSATSSPAPSIGPPASSGPTLFRPEPIASSASSSAAATVTSPGGGGGGSGGGGGSGGNGGGGGSNCNPSLAAGSSGGGVSAGGGGASSTPITASTGSSSSSSSSSSSSSSSSSSSSSSSSSSSCGPLPGKPVYSTPSPVENTPQNNECKMVDLRGAKVASFTVEGCELICLPQAFDLFLKHLVGGLHTVYTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYNDCTNASSRPGRPPKRTQSVTSPENSHIMPHSVPGLMSPGIIPPTGLTAAAAAAAAATNAAIAEAMKVKKIKLEAMSNYHASNNQHGADSENGDMNSSVGSSGGSWDKETLHSPPSQGSQAPVAHARMPAAFSLPVSHPLNHLQHSHLPPNGLELPFMMMPHPLIPVSLPPASVTMAMSQMNHLSTIANMAAAAQVQSPPSRVETSVIKERVPDSPSPAPSLEEGRRPGSHPSSHRSSSVSSSPARTESSSDRIPVHQNGLSMNQMLMGLSPNVLPGPKEGDLAGHDMGHESKRIHIEKDETPLSTPTARDSIDKLSLTGHGQPLPPGFPSPFLFPDGLSSIETLLTNIQGLLKVAIDNARAQEKQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEALEFETKRREQAEQTLKQAASADSLRVLNDSLTPEIEADRSGGRADAERTIQDGRLYLKTTVMY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
137	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
138	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
139	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
140	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
141	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
142	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
143	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
144	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
145	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
146	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
147	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
148	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
149	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
170	Phosphorylation	KPVYSTPSPVENTPQ CCCCCCCCCCCCCCC	41.48	25195567
379	Phosphorylation	GGSWDKETLHSPPSQ CCCCCHHCCCCCCCC	35.20	26643407
382	Phosphorylation	WDKETLHSPPSQGSQ CCHHCCCCCCCCCCC	41.43	26643407
385	Phosphorylation	ETLHSPPSQGSQAPV HCCCCCCCCCCCCCC	51.02	26643407
484	Phosphorylation	IKERVPDSPSPAPSL EEECCCCCCCCCCCH	22.62	10502109
486	Phosphorylation	ERVPDSPSPAPSLEE ECCCCCCCCCCCHHC	37.33	22817900
490	Phosphorylation	DSPSPAPSLEEGRRP CCCCCCCCHHCCCCC	50.98	22817900
508	Phosphorylation	PSSHRSSSVSSSPAR CCCCCCCCCCCCCCC	27.54	27841257
511	Phosphorylation	HRSSSVSSSPARTES CCCCCCCCCCCCCCC	37.88	27841257
512	Phosphorylation	RSSSVSSSPARTESS CCCCCCCCCCCCCCC	18.31	27841257
571	Phosphorylation	IHIEKDETPLSTPTA EEECCCCCCCCCCCH	39.40	27742792
574	Phosphorylation	EKDETPLSTPTARDS CCCCCCCCCCCHHHH	33.28	21183079
575	Phosphorylation	KDETPLSTPTARDSI CCCCCCCCCCHHHHC	32.13	27742792
577	Phosphorylation	ETPLSTPTARDSIDK CCCCCCCCHHHHCCH	34.12	26643407
581	Phosphorylation	STPTARDSIDKLSLT CCCCHHHHCCHHHCC	27.42	26643407
718	Phosphorylation	SLRVLNDSLTPEIEA HHHHHHCCCCCCEEC	32.82	24759943
720	Phosphorylation	RVLNDSLTPEIEADR HHHHCCCCCCEECCC	23.87	23527152

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DACH1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DACH1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DACH1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIX1_MOUSE	Six1	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.