dbPTM

CYAC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CYAC3_HUMAN
UniProt AC	Q8NBI2
Protein Name	Cytochrome b ascorbate-dependent protein 3
Gene Name	CYB561A3
Organism	Homo sapiens (Human).
Sequence Length	242
Subcellular Localization	Late endosome membrane Multi-pass membrane protein. Lysosome membrane Multi-pass membrane protein .
Protein Description	Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron donor (By similarity)..
Protein Sequence	MVSGRFYLSCLLLGSLGSMCILFTIYWMQYWRGGFAWNGSIYMFNWHPVLMVAGMVVFYGGASLVYRLPQSWVGPKLPWKLLHAALHLMAFVLTVVGLVAVFTFHNHGRTANLYSLHSWLGITTVFLFACQWFLGFAVFLLPWASMWLRSLLKPIHVFFGAAILSLSIASVISGINEKLFFSLKNTTRPYHSLPSEAVFANSTGMLVVAFGLLVLYILLASSWKRPEPGILTDRQPLLHDGE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6 (in isoform 2)	Phosphorylation	-	9.09	30108239
8 (in isoform 2)	Phosphorylation	-	2.40	30108239
11 (in isoform 2)	Phosphorylation	-	3.88	30108239
38	N-linked_Glycosylation	WRGGFAWNGSIYMFN HCCCCCCCCEEEEEE	30.79	UniProtKB CARBOHYD
150	Phosphorylation	WASMWLRSLLKPIHV HHHHHHHHHHHHHHH	35.56	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CYAC3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CYAC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CYAC3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
AOC1_HUMAN	AOC1	physical	21516116

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CYAC3_HUMAN

Related Literatures of Post-Translational Modification