| UniProt ID | AOC1_HUMAN | |
|---|---|---|
| UniProt AC | P19801 | |
| Protein Name | Amiloride-sensitive amine oxidase [copper-containing] | |
| Gene Name | AOC1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 751 | |
| Subcellular Localization | Secreted, extracellular space. | |
| Protein Description | Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.. | |
| Protein Sequence | MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSSTTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLPGPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDRCLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNGKFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGPRLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYGGHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFEMPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMHATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENITNPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRTYRLQIHSMADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQNDPWHPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPEDPSLASRDTVIVWPRDNGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 61 | Phosphorylation | LRLQPSSTTTMAKNT EECCCCCCCCHHHHH | 50558855 | ||
| 62 | Phosphorylation | RLQPSSTTTMAKNTV ECCCCCCCCHHHHHE | 50558863 | ||
| 63 | Phosphorylation | LQPSSTTTMAKNTVF CCCCCCCCHHHHHEE | 50558871 | ||
| 68 | Phosphorylation | TTTMAKNTVFLIEML CCCHHHHHEEEEEHH | 46157277 | ||
| 110 | N-linked_Glycosylation | FGDQEHPNVTEFAVG ECCCCCCCCCEEEEE | 19764817 | ||
| 129 | Phosphorylation | PCYMRALSPRPGYQS CCEEEECCCCCCCCC | 24719451 | ||
| 134 | Phosphorylation | ALSPRPGYQSSWASR ECCCCCCCCCCCCCC | 29978859 | ||
| 136 | Phosphorylation | SPRPGYQSSWASRPI CCCCCCCCCCCCCCC | 29978859 | ||
| 137 | Phosphorylation | PRPGYQSSWASRPIS CCCCCCCCCCCCCCC | 29978859 | ||
| 140 | Phosphorylation | GYQSSWASRPISTAE CCCCCCCCCCCCHHH | 29978859 | ||
| 144 | Phosphorylation | SWASRPISTAEYALL CCCCCCCCHHHHHHH | 29978859 | ||
| 145 | Phosphorylation | WASRPISTAEYALLY CCCCCCCHHHHHHHH | 29978859 | ||
| 148 | Phosphorylation | RPISTAEYALLYHTL CCCCHHHHHHHHHHH | 29978859 | ||
| 152 | Phosphorylation | TAEYALLYHTLQEAT HHHHHHHHHHHHHHC | 29978859 | ||
| 154 | Phosphorylation | EYALLYHTLQEATKP HHHHHHHHHHHHCCC | 29978859 | ||
| 159 | Phosphorylation | YHTLQEATKPLHQFF HHHHHHHCCCHHHHH | 29978859 | ||
| 168 | N-linked_Glycosylation | PLHQFFLNTTGFSFQ CHHHHHHCCCCCCHH | UniProtKB CARBOHYD | ||
| 275 | Phosphorylation | PGGKGHDSTEEPPLF CCCCCCCCCCCCCCC | 28857561 | ||
| 276 | Phosphorylation | GGKGHDSTEEPPLFS CCCCCCCCCCCCCCC | 28857561 | ||
| 276 | O-linked_Glycosylation | GGKGHDSTEEPPLFS CCCCCCCCCCCCCCC | 55828387 | ||
| 284 | Phosphorylation | EEPPLFSSHKPRGDF CCCCCCCCCCCCCCC | 46157271 | ||
| 436 | Methylation | RHFNSNFKGGFNFYA HHCCCCCCCCCEEEC | - | ||
| 461 | Other | TTSTVYNYDYIWDFI ECCEECCCCEEEEEE | 19764817 | ||
| 461 | "2',4',5'-topaquinone" | TTSTVYNYDYIWDFI ECCEECCCCEEEEEE | - | ||
| 538 | N-linked_Glycosylation | TLQMKLENITNPWSP HHHHHHHCCCCCCCC | 19764817 | ||
| 544 | Phosphorylation | ENITNPWSPRHRVVQ HCCCCCCCCCCCCCC | 24719451 | ||
| 576 | Phosphorylation | FKRKLPKYLLFTSPQ HHHCCCCEEEECCCC | 26074081 | ||
| 580 | Phosphorylation | LPKYLLFTSPQENPW CCCEEEECCCCCCCC | 26074081 | ||
| 581 | Phosphorylation | PKYLLFTSPQENPWG CCEEEECCCCCCCCC | 26074081 | ||
| 626 | Ubiquitination | RYPLAVTKYRESELC CCCEEEEECCHHHHC | - | ||
| 707 | Phosphorylation | NFFPEDPSLASRDTV CCCCCCCCCCCCCEE | 25002506 | ||
| 745 | N-linked_Glycosylation | MPPPFSYNGTYRPV- CCCCCCCCCCCCCC- | 19764817 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AOC1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AOC1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AOC1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of AOC1_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
