| UniProt ID | CXCR5_HUMAN | |
|---|---|---|
| UniProt AC | P32302 | |
| Protein Name | C-X-C chemokine receptor type 5 | |
| Gene Name | CXCR5 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 372 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein. |
|
| Protein Description | Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.. | |
| Protein Sequence | MNYPLTLEMDLENLEDLFWELDRLDNYNDTSLVENHLCPATEGPLMASFKAVFVPVAYSLIFLLGVIGNVLVLVILERHRQTRSSTETFLFHLAVADLLLVFILPFAVAEGSVGWVLGTFLCKTVIALHKVNFYCSSLLLACIAVDRYLAIVHAVHAYRHRRLLSIHITCGTIWLVGFLLALPEILFAKVSQGHHNNSLPRCTFSQENQAETHAWFTSRFLYHVAGFLLPMLVMGWCYVGVVHRLRQAQRRPQRQKAVRVAILVTSIFFLCWSPYHIVIFLDTLARLKAVDNTCKLNGSLPVAITMCEFLGLAHCCLNPMLYTFAGVKFRSDLSRLLTKLGCTGPASLCQLFPSWRRSSLSESENATSLTTF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 28 | N-linked_Glycosylation | LDRLDNYNDTSLVEN HHCCCCCCCCCHHHC | 52.95 | UniProtKB CARBOHYD | |
| 48 | Phosphorylation | TEGPLMASFKAVFVP CCCCCHHHHHHHHHH | 17.20 | 24719451 | |
| 196 | N-linked_Glycosylation | KVSQGHHNNSLPRCT HHHCCCCCCCCCCCC | 33.83 | UniProtKB CARBOHYD | |
| 339 | Ubiquitination | DLSRLLTKLGCTGPA HHHHHHHHHCCCCCH | 42.74 | - | |
| 354 | Phosphorylation | SLCQLFPSWRRSSLS HHHHHCHHHCHHCCC | 26.36 | 26091039 | |
| 358 | Phosphorylation | LFPSWRRSSLSESEN HCHHHCHHCCCCCCC | 27.36 | 28857561 | |
| 359 | Phosphorylation | FPSWRRSSLSESENA CHHHCHHCCCCCCCC | 33.82 | 30108239 | |
| 361 | Phosphorylation | SWRRSSLSESENATS HHCHHCCCCCCCCCC | 40.81 | 27251275 | |
| 363 | Phosphorylation | RRSSLSESENATSLT CHHCCCCCCCCCCCC | 32.54 | 27251275 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CXCR5_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CXCR5_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CXCR5_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CXCR4_HUMAN | CXCR4 | physical | 23773523 | |
| GBB3_HUMAN | GNB3 | physical | 23773523 | |
| GBG8_HUMAN | GNG8 | physical | 23773523 | |
| GNAI2_HUMAN | GNAI2 | physical | 23773523 | |
| GNA11_HUMAN | GNA11 | physical | 23773523 | |
| GNA13_HUMAN | GNA13 | physical | 23773523 | |
| GNAI2_HUMAN | GNAI2 | physical | 25241761 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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