CREBA_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CREBA_DROME
• UniProt AC: P29747
• Protein Name: Cyclic AMP response element-binding protein A
• Gene Name: CrebA
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 516
• Subcellular Localization: Nucleus.
• Protein Description: Transcriptional activator. Binds to fat body-specific enhancers of alcohol dehydrogenase (ADH) and yolk protein genes. BBF-2 may play a role in fat body gene expression. It binds the consensus sequence 5'-T[AC]NACGTAN[TG]C-3'..
• Protein Sequence: MEFYDGDLKDIWDSDLDPESLKISPDHDMHDWLFDRDVKDPTVILNDKLISDALLNGTQPIKTEHSYSLSSDVDSLPDSPKSLQAKIEDMDDECFPAISPKTATNGRVTIDPKYLTFHVPPTHATPISRLSSNPALNTSVADLTRSSGLQSLQAHQPHHGSGSSHVVVANLEHFQLPQHLYDNDCSSSVSSLRDGSMSPDICSDIEIDESAIKDEPMSPDSSCPASPTSQASSSQHQLSLNLAHLQSEMLFEPKHCGLLLTASSNSNNSLIKSQQRQQQILGQDNLLMAKMEIKSEKQSTSNSSDKSHAHGYGIPLTPPSSLPSDDSEGNLSPEHLFAPLSPNATVSISVANPAGGESSVRVSRTAASITRSSSGSASASGSSTSSTVTTTRQPIHTPLISSQPKGSTGTLLLTEEEKRTLLAEGYPIPQKLPLTKAEEKSLKKIRRKIKNKISAQESRRKKKEYMDQLERRVEILVTENHDYKKRLEGLEETNANLLSQLHKLQALVSKHNVKKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
75	Phosphorylation	SLSSDVDSLPDSPKS ECCCCCCCCCCCCHH	41.47	22817900
79	Phosphorylation	DVDSLPDSPKSLQAK CCCCCCCCCHHHHHH	32.08	22817900
82	Phosphorylation	SLPDSPKSLQAKIED CCCCCCHHHHHHHHH	29.15	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CREBA_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CREBA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CREBA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CREBA_DROME	CrebA	physical	23661758

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75; SER-79 AND SER-82,AND MASS SPECTROMETRY.
PubMed: 18327897