CP4V2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CP4V2_HUMAN
• UniProt AC: Q6ZWL3
• Protein Name: Cytochrome P450 4V2
• Gene Name: CYP4V2
• Organism: Homo sapiens (Human).
• Sequence Length: 525
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass membrane protein .
• Protein Description: Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the eye. [PubMed: 19661213]
• Protein Sequence: MAGLWLGLVWQKLLLWGAASALSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRRNADER

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
120	Acetylation	TSSKQIDKSSMYKFL ECCCCCCHHHHHHHH	46.16	19815069
125	Acetylation	IDKSSMYKFLEPWLG CCHHHHHHHHHHHHH	34.53	19815077
257	Phosphorylation	EGWEHKKSLQILHTF HCHHCHHHHHHHHHH	30.25	27732954
263	Phosphorylation	KSLQILHTFTNSVIA HHHHHHHHHHHHHHH	28.80	27732954
265	Phosphorylation	LQILHTFTNSVIAER HHHHHHHHHHHHHHH	27.95	27732954
267	Phosphorylation	ILHTFTNSVIAERAN HHHHHHHHHHHHHHH	16.31	27732954
307	Phosphorylation	LDLLLSVTDDEGNRL HHHHHHEECCCCCCC	34.06	30257219
403	Phosphorylation	PLFARSVSEDCEVAG CEEECCCCCCCCCCC	29.03	28857561
411	Phosphorylation	EDCEVAGYRVLKGTE CCCCCCCEEEECCCE	6.44	-
415	Ubiquitination	VAGYRVLKGTEAVII CCCEEEECCCEEEEE	62.01	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CP4V2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CP4V2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CP4V2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIN3A_HUMAN	SIN3A	physical	16030350
ZN420_HUMAN	ZNF420	physical	21988832
GATC_HUMAN	GATC	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.