CP4FB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CP4FB_HUMAN
• UniProt AC: Q9HBI6
• Protein Name: Phylloquinone omega-hydroxylase CYP4F11 {ECO:0000305}
• Gene Name: CYP4F11 {ECO:0000312|HGNC:HGNC:13265}
• Organism: Homo sapiens (Human).
• Sequence Length: 524
• Subcellular Localization: Microsome membrane ; Single-pass membrane protein .
• Protein Description: Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation. [PubMed: 24138531 Catalyzes omega-hydroxylation of 3-hydroxy fatty acids, such as 3-hydroxypalmitate, 3-hydroxyoleate, 3-hydroxyarachidonate, and 3-hydroxystearate]
• Protein Sequence: MPQLSLSWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWFWGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTEPRRKPELILRAEGGLWLRVEPLGANSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
68	Phosphorylation	WGHQGLVTPTEEGMK CCCCCCCCCCHHHHH	29.54	-
76	Phosphorylation	PTEEGMKTLTQLVTT CCHHHHHHHHHHHHH	26.58	20071362
78	Phosphorylation	EEGMKTLTQLVTTYP HHHHHHHHHHHHHCC	25.70	20071362
82	Phosphorylation	KTLTQLVTTYPQGFK HHHHHHHHHCCCCEE	29.25	20071362
152	Phosphorylation	SRHRRMLTPAFHFNI HHHHHHCCHHHHHHH	11.83	-
177	Ubiquitination	SVNIMHDKWQRLASE CHHHHHHHHHHHHHH	30.46	33845483
196	Phosphorylation	LDMFEHISLMTLDSL CCHHHHHHHHCHHHH	17.62	-
221	Phosphorylation	CQEKPSEYIAAILEL CCCCHHHHHHHHHHH	10.53	-
288	Ubiquitination	QGIDDFLKNKAKSKT CCHHHHHHHHHHCCC	57.29	-
288	Ubiquitination	QGIDDFLKNKAKSKT CCHHHHHHHHHHCCC	57.29	22817900
290	Ubiquitination	IDDFLKNKAKSKTLD HHHHHHHHHHCCCCC	56.45	22817900
292	Ubiquitination	DFLKNKAKSKTLDFI HHHHHHHHCCCCCHH	54.84	22817900
294	Ubiquitination	LKNKAKSKTLDFIDV HHHHHHCCCCCHHHE	53.02	33845483
306	Ubiquitination	IDVLLLSKDEDGKEL HHEEECCCCCCCCCC	66.17	29901268
311	Ubiquitination	LSKDEDGKELSDEDI CCCCCCCCCCCHHHH	68.73	33845483
314	Phosphorylation	DEDGKELSDEDIRAE CCCCCCCCHHHHHHH	39.79	-
363	Ubiquitination	QEVQELLKDREPIEI HHHHHHHHCCCCCCC	68.32	33845483
451	Ubiquitination	RFDQENIKERSPLAF CCCHHCHHCCCCCEE	59.67	-
451	Ubiquitination	RFDQENIKERSPLAF CCCHHCHHCCCCCEE	59.67	29901268
501	Ubiquitination	THTEPRRKPELILRA CCCCCCCCCEEEEEE	44.09	29901268
515	Methylation	AEGGLWLRVEPLGAN EECCEEEEEEECCCC	21.12	-
523	Phosphorylation	VEPLGANSQ------ EEECCCCCC------	36.41	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CP4FB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CP4FB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CP4FB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
POTE1_HUMAN	POT1	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.