COPZ2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COPZ2_HUMAN
• UniProt AC: Q9P299
• Protein Name: Coatomer subunit zeta-2
• Gene Name: COPZ2
• Organism: Homo sapiens (Human).
• Sequence Length: 210
• Subcellular Localization: Cytoplasm. Endoplasmic reticulum-Golgi intermediate compartment membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral
• Protein Description: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity)..
• Protein Sequence: MQRPEAWPRPHPGEGAAAAQAGGPAPPARAGEPSGLRLQEPSLYTIKAVFILDNDGRRLLAKYYDDTFPSMKEQMVFEKNVFNKTSRTESEIAFFGGMTIVYKNSIDLFLYVVGSSYENELMLMSVLTCLFESLNHMLRKNVEKRWLLENMDGAFLVLDEIVDGGVILESDPQQVIQKVNFRADDGGLTEQSVAQVLQSAKEQIKWSLLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	Ubiquitination	DDTFPSMKEQMVFEK CCCCCHHHHHHHHEE	49.48	29967540
86	Phosphorylation	KNVFNKTSRTESEIA ECCCCCCCCCHHHEE	38.52	-
175	Ubiquitination	LESDPQQVIQKVNFR ECCCHHHHHHHCCCC	4.16	22817900
179	Ubiquitination	PQQVIQKVNFRADDG HHHHHHHCCCCCCCC	4.73	22817900
189	Phosphorylation	RADDGGLTEQSVAQV CCCCCCCCHHHHHHH	34.94	-
201	Ubiquitination	AQVLQSAKEQIKWSL HHHHHHHHHHHHHHH	56.23	22817900
205	Ubiquitination	QSAKEQIKWSLLK-- HHHHHHHHHHHCC--	30.35	22817900
207	Phosphorylation	AKEQIKWSLLK---- HHHHHHHHHCC----	20.87	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COPZ2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COPZ2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COPZ2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COPG1_HUMAN	COPG1	physical	10921873
COPZ2_HUMAN	COPZ2	physical	14729954
COPG1_HUMAN	COPG1	physical	14729954

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.