COG3_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COG3_DROME
• UniProt AC: Q961G1
• Protein Name: Conserved oligomeric Golgi complex subunit 3
• Gene Name: Cog3
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 905
• Subcellular Localization: Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
• Protein Description: Involved in ER-Golgi transport..
• Protein Sequence: MDDVERIQSENENLRKIRNRLMQWESKTDPLAALSIQQEEHLDVLTNLWRDSGPSAPAPTTPTQVGPTDSSAAATSQSGDDIRLPAEGLQNTNEFLLWFADVSAEIEQRGDADYHKYLQQLEQRKAECSHMLDQIAGAMERLGALCDEYDFVSQKTSALNTASEQLIEEQERLQELSHEIQRRLHYFSQVELLNQRLQSPTLSVASEAFRECLNKIDECLNYIEENPKFKDAAAYNVKYRQCLAKASGLVRNYVTSVINQATEATLHPKNNMPDASAALKAPDAAFALYYGKYQTAAAKVKRVAQLIESRSEHSLDYAQLMADLQQHYLAQRASVMSPAVNLSIQNVKVAHKGDHCSLTRSACAFLVHVCQDEQRLFYQFFSTGAPHLTVYLEGLCTILYDTMRPFIIHINHLETLAEICSILRIEMLEEHVQQNPVALEAFATIAHQLLQDVQERLVFRAHLYLQSDIQNFNPSSGDLAYPEKLEMMESIALSLQEPAPLRRSDSRNSMVSSVSSAVETESVATAYTVKQMNSPADLHGMWYPTVRRTLVCLSRLYRCVDRPIFQGLSQEALKLCIQSVSHAAGKISANKTPIDGELFEIKHLLILREQIAPFRVDFTVKETSLDFSKVKTAAFGLLQKRKQLFSMGSNNALLEFLLEGTPQIKEHLLDSRKEVDRQLKSVCEKYIKDAVQMLVGPLITFLEKAQSLLAQSTPATPQSPESTKASYVLRQSPWASPQQISSIIQETQRLIKAKLAVLQRSMQLYLSNRDTEFIIFRPIRNNIIQSFVKLEQLLTTNGYSTDDMIITSCPSAEQVSILLSSASILAAEGVASFAAAARKISTSSSVEGSTVGRKLSAMSNKSELVEEPKVEEVAGQIEVVPAEVQPPAKIEEEEVTETQTQANSE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	Phosphorylation	GPSAPAPTTPTQVGP CCCCCCCCCCCCCCC	47.73	19429919
61	Phosphorylation	PSAPAPTTPTQVGPT CCCCCCCCCCCCCCC	24.23	19429919
63	Phosphorylation	APAPTTPTQVGPTDS CCCCCCCCCCCCCCC	33.52	19429919
68	Phosphorylation	TPTQVGPTDSSAAAT CCCCCCCCCCCCCHH	42.45	19429919
516	Phosphorylation	SMVSSVSSAVETESV CCCCCHHHCCCCCCH	33.89	22668510
646	Phosphorylation	QKRKQLFSMGSNNAL HHHHHHHHCCCCHHH	30.72	19429919
649	Phosphorylation	KQLFSMGSNNALLEF HHHHHCCCCHHHHHH	20.47	19429919
841	Phosphorylation	AAAARKISTSSSVEG HHHHHHHCCCCCCCC	25.85	19429919
842	Phosphorylation	AAARKISTSSSVEGS HHHHHHCCCCCCCCC	35.78	19429919
843	Phosphorylation	AARKISTSSSVEGST HHHHHCCCCCCCCCH	17.52	19429919
844	Phosphorylation	ARKISTSSSVEGSTV HHHHCCCCCCCCCHH	38.19	19429919
845	Phosphorylation	RKISTSSSVEGSTVG HHHCCCCCCCCCHHH	24.77	19429919
849	Phosphorylation	TSSSVEGSTVGRKLS CCCCCCCCHHHHHHH	13.35	25749252
856	Phosphorylation	STVGRKLSAMSNKSE CHHHHHHHHHCCCHH	25.59	22817900
859	Phosphorylation	GRKLSAMSNKSELVE HHHHHHHCCCHHHCC	40.60	22817900
862	Phosphorylation	LSAMSNKSELVEEPK HHHHCCCHHHCCCCC	40.17	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COG3_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COG3_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COG3_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARP3_DROME	Arp3	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-841; SER-845; SER-856;SER-859 AND SER-862, AND MASS SPECTROMETRY.
PubMed: 18327897