dbPTM

CNRG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CNRG_HUMAN
UniProt AC	P18545
Protein Name	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Gene Name	PDE6G
Organism	Homo sapiens (Human).
Sequence Length	87
Subcellular Localization
Protein Description	Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones..
Protein Sequence	MNLEPPKAEFRSATRVAGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGLGTDITVICPWEAFNHLELHELAQYGII

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNLEPPKA -------CCCCCCHH	13.41	-
22	Phosphorylation	RVAGGPVTPRKGPPK EECCCCCCCCCCCCC	22.10	12624098
25	Ubiquitination	GGPVTPRKGPPKFKQ CCCCCCCCCCCCHHH	76.58	-
36	Dimethylation	KFKQRQTRQFKSKPP CHHHHCHHHHCCCCC	31.44	-
36	Methylation	KFKQRQTRQFKSKPP CHHHHCHHHHCCCCC	31.44	24390035
62	Phosphorylation	PGMEGLGTDITVICP CCCCCCCCCEEEEEC	29.30	12624098

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
62	T	Phosphorylation	Kinase	ADRBK1	P25098	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CNRG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CNRG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRC_HUMAN	SRC	physical	12624098
ARBK1_HUMAN	ADRBK1	physical	12624098
GRB2_HUMAN	GRB2	physical	12624098
DYN2_HUMAN	DNM2	physical	12624098
BHE40_HUMAN	BHLHE40	physical	25416956
LMBL3_HUMAN	L3MBTL3	physical	25416956

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
613582	Retinitis pigmentosa 57 (RP57)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00203	Sildenafil
DB00862	Vardenafil

Regulatory Network of CNRG_HUMAN

Related Literatures of Post-Translational Modification