CLV2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLV2_ARATH
• UniProt AC: O80809
• Protein Name: Receptor-like protein CLAVATA2 {ECO:0000312|EMBL:AAF02654.1, ECO:0000312|EMBL:AAF02655.1, ECO:0000312|EMBL:AAF02656.1}
• Gene Name: CLV2 {ECO:0000312|EMBL:AAF02654.1, ECO:0000312|EMBL:AAF02655.1, ECO:0000312|EMBL:AAF02656.1}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 720
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Requires CRN for export from the endoplasmic reticulum and localization to the plasma membrane.
• Protein Description: Involved in the perception of CLV3 and CLV3-like (CLE) peptides, that act as extracellular signals regulating meristems maintenance. Involved in controlling the stem cell population size in shoot and root apical meristems, and during organ development. Promotes the formation of CLV1 multimers. In complex with CRN, perceives secreted CLV3-like effector proteins from plant-parasitic cyst nematodes as ligand mimics of the plant CLE signaling pathway. [PubMed: 21265896]
• Protein Sequence: MIKIADFTLFFFIFVFSPSLPLAQSQLPDLDPQDKASLLIFRVSIHDLNRSLSTWYGSSCSNWTGLACQNPTGKVLSLTLSGLNLSSQIHPSLCKLSSLQSLDLSHNNFSGNIPSCFGSLRNLRTLNLSRNRFVGSIPATFVSLKELREVVLSENRDLGGVVPHWFGNFSMNLERVDFSFCSFVGELPESLLYLKSLKYLNLESNNMTGTLRDFQQPLVVLNLASNQFSGTLPCFYASRPSLSILNIAENSLVGGLPSCLGSLKELSHLNLSFNGFNYEISPRLMFSEKLVMLDLSHNGFSGRLPSRISETTEKLGLVLLDLSHNSFSGDIPLRITELKSLQALRLSHNLLTGDIPARIGNLTYLQVIDLSHNALTGSIPLNIVGCFQLLALMISNNNLSGEIQPELDALDSLKILDISNNHISGEIPLTLAGLKSLEIVDISSNNLSGNLNEAITKWSNLKYLSLARNKFSGTLPSWLFKFDKIQMIDYSSNRFSWFIPDDNLNSTRFKDFQTGGGEGFAEPPGKVEIKISAAVVAKDELSFSYNLLSMVGIDLSDNLLHGEIPEALFRQKNIEYLNLSYNFLEGQLPRLEKLPRLKALDLSHNSLSGQVIGNISAPPGLTLLNLSHNCFSGIITEKEGLGKFPGALAGNPELCVETPGSKCDPANIDASQEEIYQNELVEGPISIWIFCLSAFISFDFGVLGIFCSARARSYILQTKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	N-linked_Glycosylation	RVSIHDLNRSLSTWY EEEHHHHCHHHHHCC	37.24	-
62	N-linked_Glycosylation	WYGSSCSNWTGLACQ CCCCCCCCCCCEEEC	44.66	-
84	N-linked_Glycosylation	SLTLSGLNLSSQIHP EEEEECCCCCCCCCH	41.21	-
108	N-linked_Glycosylation	SLDLSHNNFSGNIPS CCCCCCCCCCCCCCC	27.34	-
127	N-linked_Glycosylation	LRNLRTLNLSRNRFV HHCCCEEECCCCCCC	35.04	-
168	N-linked_Glycosylation	VVPHWFGNFSMNLER CCCHHCCCCCCCCEE	19.15	-
206	N-linked_Glycosylation	YLNLESNNMTGTLRD EEECCCCCCCCCHHH	38.38	-
270	N-linked_Glycosylation	LKELSHLNLSFNGFN HHHHHCCCEEECCCC	28.37	-
361	N-linked_Glycosylation	DIPARIGNLTYLQVI CCCCCCCCEEEEEEE	27.17	-
398	N-linked_Glycosylation	ALMISNNNLSGEIQP HHHHHCCCCCCCCCC	39.57	-
446	N-linked_Glycosylation	IVDISSNNLSGNLNE EEECCCCCCCCCHHH	37.22	-
505	N-linked_Glycosylation	FIPDDNLNSTRFKDF ECCCCCCCCCCCCCC	47.81	-
578	N-linked_Glycosylation	QKNIEYLNLSYNFLE HCCCEEEEECHHHHH	26.49	-
614	N-linked_Glycosylation	LSGQVIGNISAPPGL CCCCEEECCCCCCCC	17.58	-
625	N-linked_Glycosylation	PPGLTLLNLSHNCFS CCCCEEEECCCCCCC	42.48	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLV2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLV2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLV2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CRN_ARATH	CRN	physical	20626648
CDPK1_ARATH	CPK1	physical	22737156
MLO4_ARATH	MLO4	physical	22737156
CCI1_ARATH	CPI1	physical	23776660

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.