CLM8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLM8_HUMAN
• UniProt AC: Q9UGN4
• Protein Name: CMRF35-like molecule 8
• Gene Name: CD300A
• Organism: Homo sapiens (Human).
• Sequence Length: 299
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. [PubMed: 10746781]
• Protein Sequence: MWLPWALLLLWVPGCFALSKCRTVAGPVGGSLSVQCPYEKEHRTLNKYWCRPPQIFLCDKIVETKGSAGKRNGRVSIRDSPANLSFTVTLENLTEEDAGTYWCGVDTPWLRDFHDPVVEVEVSVFPASTSMTPASITAAKTSTITTAFPPVSSTTLFAVGATHSASIQEETEEVVNSQLPLLLSLLALLLLLLVGASLLAWRMFQKWIKAGDHSELSQNPKQAATQSELHYANLELLMWPLQEKPAPPREVEVEYSTVASPREELHYASVVFDSNTNRIAAQRPREEEPDSDYSVIRKT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
83	N-linked_Glycosylation	SIRDSPANLSFTVTL EEECCCCCEEEEEEE	39.33	UniProtKB CARBOHYD
92	N-linked_Glycosylation	SFTVTLENLTEEDAG EEEEEECCCCHHHCC	56.21	UniProtKB CARBOHYD
214	Phosphorylation	WIKAGDHSELSQNPK HHHCCCCHHHCCCHH	45.00	23312004
217	Phosphorylation	AGDHSELSQNPKQAA CCCCHHHCCCHHHHH	24.70	25072903
225	Phosphorylation	QNPKQAATQSELHYA CCHHHHHHHHHHHHH	35.33	29978859
227	Phosphorylation	PKQAATQSELHYANL HHHHHHHHHHHHHHH	37.46	29978859
231	Phosphorylation	ATQSELHYANLELLM HHHHHHHHHHHHHHE	15.15	29978859
244	Ubiquitination	LMWPLQEKPAPPREV HEEECCCCCCCCCEE	33.25	-
255	Phosphorylation	PREVEVEYSTVASPR CCEEEEEEECCCCCC	18.15	27259358
256	Phosphorylation	REVEVEYSTVASPRE CEEEEEEECCCCCCH	11.69	30108239
257	Phosphorylation	EVEVEYSTVASPREE EEEEEEECCCCCCHH	21.13	23532336
260	Phosphorylation	VEYSTVASPREELHY EEEECCCCCCHHEEE	21.83	26657352
267	Phosphorylation	SPREELHYASVVFDS CCCHHEEEEEEEECC	17.13	27259358
269	Phosphorylation	REELHYASVVFDSNT CHHEEEEEEEECCCC	16.20	26657352
291	Phosphorylation	PREEEPDSDYSVIRK CCCCCCCCCCCCEEC	49.52	29978859
293	Phosphorylation	EEEPDSDYSVIRKT- CCCCCCCCCCEECC-	14.59	29978859
294	Phosphorylation	EEPDSDYSVIRKT-- CCCCCCCCCEECC--	18.96	29978859
299	Phosphorylation	DYSVIRKT------- CCCCEECC-------	33.71	30177828

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLM8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLM8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLM8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR103_HUMAN	KRTAP10-3	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.