CLC4M_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLC4M_HUMAN
• UniProt AC: Q9H2X3
• Protein Name: C-type lectin domain family 4 member M
• Gene Name: CLEC4M
• Organism: Homo sapiens (Human).
• Sequence Length: 399
• Subcellular Localization: Isoform 1: Cell membrane ; Single-pass type II membrane protein .; Isoform 2: Cell membrane ; Single-pass type II membrane protein .; Isoform 3: Cell membrane ; Single-pass type II membrane protein .; Isoform 5: Secreted .; Isoform 6: Secreted .; Isoform
• Protein Description: Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.; (Microbial infection) Acts as an attachment receptor for Ebolavirus.; (Microbial infection) Acts as an attachment receptor for Hepatitis C virus.; (Microbial infection) Acts as an attachment receptor for HIV-1.; (Microbial infection) Acts as an attachment receptor for Human coronavirus 229E.; (Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5.; (Microbial infection) Acts as an attachment receptor for Influenzavirus.; (Microbial infection) Acts as an attachment receptor for SARS coronavirus.; (Microbial infection) Acts as an attachment receptor for West-nile virus.; (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus.; (Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein.; (Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule..
• Protein Sequence: MSDSKEPRVQQLGLLEEDPTTSGIRLFPRDFQFQQIHGHKSSTGCLGHGALVLQLLSFMLLAGVLVAILVQVSKVPSSLSQEQSEQDAIYQNLTQLKAAVGELSEKSKLQEIYQELTQLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTELKAAVGELPEKSKLQEIYQELTQLKAAVGELPDQSKQQQIYQELTDLKTAFERLCRHCPKDWTFFQGNCYFMSNSQRNWHDSVTACQEVRAQLVVIKTAEEQNFLQLQTSRSNRFSWMGLSDLNQEGTWQWVDGSPLSPSFQRYWNSGEPNNSGNEDCAEFSGSGWNDNRCDVDNYWICKKPAACFRDE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
92	N-linked_Glycosylation	EQDAIYQNLTQLKAA HHHHHHHHHHHHHHH	28.25	UniProtKB CARBOHYD
104	Phosphorylation	KAAVGELSEKSKLQE HHHHHHHCHHHHHHH	38.38	22210691
107	Phosphorylation	VGELSEKSKLQEIYQ HHHHCHHHHHHHHHH	34.25	-
113	Phosphorylation	KSKLQEIYQELTQLK HHHHHHHHHHHHHHH	8.65	-
120	Acetylation	YQELTQLKAAVGELP HHHHHHHHHHHCCCC	25.20	7432075
130	Phosphorylation	VGELPEKSKLQEIYQ HCCCCCHHHHHHHHH	36.62	-
136	Phosphorylation	KSKLQEIYQELTRLK HHHHHHHHHHHHHHH	8.65	-
143	Acetylation	YQELTRLKAAVGELP HHHHHHHHHHHCCCC	30.89	7432083
153	Phosphorylation	VGELPEKSKLQEIYQ HCCCCCHHHHHHHHH	36.62	-
159	Phosphorylation	KSKLQEIYQELTRLK HHHHHHHHHHHHHHH	8.65	-
166	Acetylation	YQELTRLKAAVGELP HHHHHHHHHHHCCCC	30.89	7432091
176	Phosphorylation	VGELPEKSKLQEIYQ HCCCCCHHHHHHHHH	36.62	-
182	Phosphorylation	KSKLQEIYQELTRLK HHHHHHHHHHHHHHH	8.65	-
189	Acetylation	YQELTRLKAAVGELP HHHHHHHHHHHCCCC	30.89	7432099
199	Phosphorylation	VGELPEKSKLQEIYQ HCCCCCHHHHHHHHH	36.62	-
212	Acetylation	YQELTELKAAVGELP HHHHHHHHHHHCCCC	28.24	7432107
222	Phosphorylation	VGELPEKSKLQEIYQ HCCCCCHHHHHHHHH	36.62	-
228	Phosphorylation	KSKLQEIYQELTQLK HHHHHHHHHHHHHHH	8.65	-
361	N-linked_Glycosylation	YWNSGEPNNSGNEDC HHHCCCCCCCCCCCH	51.50	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLC4M_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLC4M_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLC4M_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLC4M_HUMAN	CLEC4M	physical	11384997
GRN_HUMAN	GRN	physical	26186194
GRN_HUMAN	GRN	physical	28514442
GFAP_HUMAN	GFAP	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.