CKLF2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CKLF2_HUMAN
• UniProt AC: Q8TAZ6
• Protein Name: CKLF-like MARVEL transmembrane domain-containing protein 2
• Gene Name: CMTM2
• Organism: Homo sapiens (Human).
• Sequence Length: 248
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Sequence: MAPKAAKGAKPEPAPAPPPPGAKPEEDKKDGKEPSDKPQKAVQDHKEPSDKPQKAVQPKHEVGTRRGCRRYRWELKDSNKEFWLLGHAEIKIRSLGCLIAAMILLSSLTVHPILRLIITMEISFFSFFILLYSFAIHRYIPFILWPISDLFNDLIACAFLVGAVVFAVRSRRSMNLHYLLAVILIGAAGVFAFIDVCLQRNHFRGKKAKKHMLVPPPGKEKGPQQGKGPEPAKPPEPGKPPGPAKGKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Methylation	KHEVGTRRGCRRYRW HHHHCCCCCCHHEEE	48.69	-
70	Methylation	GTRRGCRRYRWELKD CCCCCCHHEEEEECC	29.46	-
119	Phosphorylation	PILRLIITMEISFFS HHHHHHHHHHHHHHH	11.19	28796482
123	Phosphorylation	LIITMEISFFSFFIL HHHHHHHHHHHHHHH	13.61	28796482
126	Phosphorylation	TMEISFFSFFILLYS HHHHHHHHHHHHHHH	19.76	28796482
132	Phosphorylation	FSFFILLYSFAIHRY HHHHHHHHHHHHHHH	9.78	28796482
133	Phosphorylation	SFFILLYSFAIHRYI HHHHHHHHHHHHHHH	14.26	28796482

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CKLF2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CKLF2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CKLF2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.