CK052_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CK052_HUMAN
• UniProt AC: Q96A22
• Protein Name: Uncharacterized protein C11orf52
• Gene Name: C11orf52
• Organism: Homo sapiens (Human).
• Sequence Length: 123
• Protein Sequence: MGNRVCCGGSWSCPSTFQKKKKTGSQTRRTLKPQPQQLQQNLPKGHETTGHTYERVLQQQGSQERSPGLMSEDSNLHYADIQVCSRPHAREVKHVHLENATEYATLRFPQATPRYDSKNGTLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	TGSQTRRTLKPQPQQ CCCCCCCCCCCCHHH	35.52	28857561
48	Phosphorylation	NLPKGHETTGHTYER HCCCCCCCCHHHHHH	32.19	-
49	Phosphorylation	LPKGHETTGHTYERV CCCCCCCCHHHHHHH	24.79	23312004
52	Phosphorylation	GHETTGHTYERVLQQ CCCCCHHHHHHHHHH	28.55	23312004
53	Phosphorylation	HETTGHTYERVLQQQ CCCCHHHHHHHHHHC	8.96	27259358
62	Phosphorylation	RVLQQQGSQERSPGL HHHHHCCCCCCCCCC	25.24	23911959
66	Phosphorylation	QQGSQERSPGLMSED HCCCCCCCCCCCCCC	23.67	29759185
71	Phosphorylation	ERSPGLMSEDSNLHY CCCCCCCCCCCCCCC	43.21	28152594
74	Phosphorylation	PGLMSEDSNLHYADI CCCCCCCCCCCCCEE	36.92	28152594
77	Phosphorylation	MSEDSNLHYADIQVC CCCCCCCCCCEEEEE	21.71	17016520
78	Phosphorylation	SEDSNLHYADIQVCS CCCCCCCCCEEEEEC	14.77	27273156
85	Phosphorylation	YADIQVCSRPHAREV CCEEEEECCCCCCCC	50.41	28152594
101	Phosphorylation	HVHLENATEYATLRF EEECCCCCCEEEEEC	40.90	27273156
103	Phosphorylation	HLENATEYATLRFPQ ECCCCCCEEEEECCC	10.67	27273156
105	Phosphorylation	ENATEYATLRFPQAT CCCCCEEEEECCCCC	19.98	27273156
112	Phosphorylation	TLRFPQATPRYDSKN EEECCCCCCCCCCCC	11.75	28152594

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CK052_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CK052_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CK052_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells.";
Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.;
J. Proteome Res. 8:3852-3861(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-78 AND TYR-103, AND MASSSPECTROMETRY.
PubMed: 19534553

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-103, AND MASSSPECTROMETRY.
PubMed: 18083107