CHIO_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CHIO_HUMAN
• UniProt AC: P52757
• Protein Name: Beta-chimaerin
• Gene Name: CHN2
• Organism: Homo sapiens (Human).
• Sequence Length: 468
• Subcellular Localization: Membrane ; Peripheral membrane protein .
• Protein Description: GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors..
• Protein Sequence: MAASSNSSLSGSSVSSDAEEYQPPIWKSYLYQLQQEAPRPKRIICPREVENRPKYYGREFHGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQTLNYRLFHDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLREKVSRRLSRSKNEPRKTNVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3 (in isoform 7)	Phosphorylation	-	16.52	29978859
3 (in isoform 6)	Phosphorylation	-	16.52	29978859
3 (in isoform 5)	Phosphorylation	-	16.52	29978859
3 (in isoform 4)	Phosphorylation	-	16.52	29978859
3 (in isoform 3)	Phosphorylation	-	16.52	29978859
4	Phosphorylation	----MAASSNSSLSG ----CCCCCCCCCCC	22.10	30177828
5	Phosphorylation	---MAASSNSSLSGS ---CCCCCCCCCCCC	35.68	30177828
7	Phosphorylation	-MAASSNSSLSGSSV -CCCCCCCCCCCCCC	34.30	30177828
8	Phosphorylation	MAASSNSSLSGSSVS CCCCCCCCCCCCCCC	30.70	30177828
10	Phosphorylation	ASSNSSLSGSSVSSD CCCCCCCCCCCCCCC	38.28	30177828
12	Phosphorylation	SNSSLSGSSVSSDAE CCCCCCCCCCCCCHH	24.96	30177828
13	Phosphorylation	NSSLSGSSVSSDAEE CCCCCCCCCCCCHHH	29.55	30177828
15	Phosphorylation	SLSGSSVSSDAEEYQ CCCCCCCCCCHHHHC	25.17	30177828
16	Phosphorylation	LSGSSVSSDAEEYQP CCCCCCCCCHHHHCC	38.39	30177828
21	Phosphorylation	VSSDAEEYQPPIWKS CCCCHHHHCCCHHHH	20.16	17560670
55	Phosphorylation	EVENRPKYYGREFHG CCCCCCCCCCCCCCC	17.52	-
85	Phosphorylation	GAYILRESQRQPGCY EEEHHHHHHCCCCEE	24.99	22210691
92	Phosphorylation	SQRQPGCYTLALRFG HHCCCCEEEEEEEEC	15.65	22210691
102	Phosphorylation	ALRFGNQTLNYRLFH EEEECCEEEEEEEEE	22.44	27067055
148	Phosphorylation	AEYISKMTTNPIYEH HHHHHHHCCCHHHHH	27.45	28796482
149	Phosphorylation	EYISKMTTNPIYEHI HHHHHHCCCHHHHHH	35.18	28796482
153	Phosphorylation	KMTTNPIYEHIGYAT HHCCCHHHHHHHHHH	11.60	28796482
158	Phosphorylation	PIYEHIGYATLLREK HHHHHHHHHHHHHHH	8.87	28796482
160	Phosphorylation	YEHIGYATLLREKVS HHHHHHHHHHHHHHH	20.17	28796482
167	Phosphorylation	TLLREKVSRRLSRSK HHHHHHHHHHHHCCC	23.81	22817900
171	Phosphorylation	EKVSRRLSRSKNEPR HHHHHHHHCCCCCCC	32.47	22817900
173	Phosphorylation	VSRRLSRSKNEPRKT HHHHHHCCCCCCCCC	36.14	22817900
192	Ubiquitination	EEHTAVEKISSLVRR HHHHHHHHHHHHHHH	41.09	-
194	Phosphorylation	HTAVEKISSLVRRAA HHHHHHHHHHHHHHH	28.78	-
195	Phosphorylation	TAVEKISSLVRRAAL HHHHHHHHHHHHHHH	34.06	24719451
211	Phosphorylation	HNDNHFNYEKTHNFK CCCCCCCCEEECCEE	20.19	27642862
213	Ubiquitination	DNHFNYEKTHNFKVH CCCCCCEEECCEEEE	44.73	-
325	Ubiquitination	TEHIEDVKMAFDRDG CHHHHHHHHHCCCCC	36.51	-
334	Ubiquitination	AFDRDGEKADISANV HCCCCCCCCCCCCEE	57.81	-
349	Phosphorylation	YPDINIITGALKLYF CCCCHHHCHHHHHHC	16.77	-
355	Phosphorylation	ITGALKLYFRDLPIP HCHHHHHHCCCCCCC	8.59	-
442	Phosphorylation	LMRPPEDSTLTTLHD CCCCCCCCCCCCHHH	24.53	26074081
443	Phosphorylation	MRPPEDSTLTTLHDM CCCCCCCCCCCHHHH	40.21	26074081
445	Phosphorylation	PPEDSTLTTLHDMRY CCCCCCCCCHHHHHH	27.65	26074081
446	Phosphorylation	PEDSTLTTLHDMRYQ CCCCCCCCHHHHHHH	25.80	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
21	Y	Phosphorylation	Kinase	FYN	P06241	PSP
21	Y	Phosphorylation	Kinase	SRC	P12931	PSP
21	Y	Phosphorylation	Kinase	SRC-FAMILY	-	GPS
153	Y	Phosphorylation	Kinase	LCK	P06239	PSP
171	S	Phosphorylation	Kinase	PRKCD	Q05655	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CHIO_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CHIO_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BAG6_HUMAN	BAG6	physical	16169070
RANB3_HUMAN	RANBP3	physical	25814554
RB_HUMAN	RB1	physical	25814554
SMRD1_HUMAN	SMARCD1	physical	25814554
PRPK_HUMAN	TP53RK	physical	25814554

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.