CGNL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CGNL1_HUMAN
• UniProt AC: Q0VF96
• Protein Name: Cingulin-like protein 1
• Gene Name: CGNL1
• Organism: Homo sapiens (Human).
• Sequence Length: 1302
• Subcellular Localization: Cell junction, tight junction . Localizes to the apical junction complex composed of tight and adherens junctions (PubMed:22891260). In the liver and kidney, it is also found along non-junctional actin filament bundles in addition to the apical junct
• Protein Description: May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons..
• Protein Sequence: MELYFGEYQHVQQEYGVHLRLASDDTQKSRSSQNSKAGSYGVSIRVQGIDGHPYIVLNNTERCLAGTSFSENGPPFPPPVINNLPLHSSNGSVPKENSEELQLPENPYAQPSPIRNLKQPLLHEGKNGVLDRKDGSVKPSHLLNFQRHPELLQPYDPEKNELNLQNHQPSESNWLKTLTEEGINNKKPWTCFPKPSNSQPTSPSLEDPAKSGVTAIRLCSSVVIEDPKKQTSVCVNVQSCTKERVGEEALFTSGRPLTAHSPHAHPETKKTRPDVLPFRRQDSAGPVLDGARSRRSSSSSTTPTSANSLYRFLLDDQECAIHADNVNRHENRRYIPFLPGTGRDIDTGSIPGVDQLIEKFDQKPGLQRRGRSGKRNRINTDDRKRSRSVDSAFPFGLQGNSEYLIEFSRNLGKSSEHLLRPSQVCPQRPLSQERRGKQSVGRTFAKLQGAAHGASCAHSRPPQPNIDGKVLETEGSQESTVIRAPSLGAQSKKEEEVKTATATLMLQNRATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLDDMDDDDDLSTDGGSLYEAPVSYTFSKDSTVASQI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	QNSKAGSYGVSIRVQ CCCCCCCCCEEEEEE	22.19	29496907
43	Phosphorylation	KAGSYGVSIRVQGID CCCCCCEEEEEEEEC	10.58	28857561
54	Phosphorylation	QGIDGHPYIVLNNTE EEECCCEEEEECCCC	9.66	-
98	Phosphorylation	GSVPKENSEELQLPE CCCCCCCCCCCCCCC	33.27	29978859
108	Phosphorylation	LQLPENPYAQPSPIR CCCCCCCCCCCCCCC	29.47	24927040
112	Phosphorylation	ENPYAQPSPIRNLKQ CCCCCCCCCCCCCCC	22.37	28152594
136	Phosphorylation	VLDRKDGSVKPSHLL CCCCCCCCCCHHHHH	36.78	28857561
140	Phosphorylation	KDGSVKPSHLLNFQR CCCCCCHHHHHCCCC	22.50	28857561
190	Phosphorylation	INNKKPWTCFPKPSN CCCCCCCCCCCCCCC	16.88	28857561
196	Phosphorylation	WTCFPKPSNSQPTSP CCCCCCCCCCCCCCC	56.06	26657352
198	Phosphorylation	CFPKPSNSQPTSPSL CCCCCCCCCCCCCCC	41.70	22617229
201	Phosphorylation	KPSNSQPTSPSLEDP CCCCCCCCCCCCCCH	45.71	26657352
202	Phosphorylation	PSNSQPTSPSLEDPA CCCCCCCCCCCCCHH	21.12	22199227
204	Phosphorylation	NSQPTSPSLEDPAKS CCCCCCCCCCCHHHC	44.13	20363803
220	Phosphorylation	VTAIRLCSSVVIEDP CCHHHHHCEEEECCC	30.66	28857561
221	Phosphorylation	TAIRLCSSVVIEDPK CHHHHHCEEEECCCC	21.29	28857561
231	Phosphorylation	IEDPKKQTSVCVNVQ ECCCCCCCEEEEEEC	31.82	-
232	Phosphorylation	EDPKKQTSVCVNVQS CCCCCCCEEEEEECC	15.83	-
239	Phosphorylation	SVCVNVQSCTKERVG EEEEEECCCCCCCCC	21.33	-
241	Phosphorylation	CVNVQSCTKERVGEE EEEECCCCCCCCCCC	40.98	-
252	Phosphorylation	VGEEALFTSGRPLTA CCCCHHCCCCCCCCC	30.99	28857561
253	Phosphorylation	GEEALFTSGRPLTAH CCCHHCCCCCCCCCC	26.02	24719451
258	Phosphorylation	FTSGRPLTAHSPHAH CCCCCCCCCCCCCCC	25.63	27251275
261	Phosphorylation	GRPLTAHSPHAHPET CCCCCCCCCCCCCCC	18.86	28857561
268	Phosphorylation	SPHAHPETKKTRPDV CCCCCCCCCCCCCCC	42.14	23312004
283	Phosphorylation	LPFRRQDSAGPVLDG CCCCCCCCCCCCCCC	27.13	23911959
293	Phosphorylation	PVLDGARSRRSSSSS CCCCCCCCCCCCCCC	31.35	24670416
296	Phosphorylation	DGARSRRSSSSSTTP CCCCCCCCCCCCCCC	33.20	23403867
297	Phosphorylation	GARSRRSSSSSTTPT CCCCCCCCCCCCCCC	32.21	23898821
298	Phosphorylation	ARSRRSSSSSTTPTS CCCCCCCCCCCCCCC	29.56	23403867
299	Phosphorylation	RSRRSSSSSTTPTSA CCCCCCCCCCCCCCH	33.38	23403867
300	Phosphorylation	SRRSSSSSTTPTSAN CCCCCCCCCCCCCHH	37.94	23403867
301	Phosphorylation	RRSSSSSTTPTSANS CCCCCCCCCCCCHHH	38.45	23403867
302	Phosphorylation	RSSSSSTTPTSANSL CCCCCCCCCCCHHHH	26.90	26657352
304	Phosphorylation	SSSSTTPTSANSLYR CCCCCCCCCHHHHHH	38.08	23403867
305	Phosphorylation	SSSTTPTSANSLYRF CCCCCCCCHHHHHHH	27.02	23403867
308	Phosphorylation	TTPTSANSLYRFLLD CCCCCHHHHHHHHHC	26.88	23403867
310	Phosphorylation	PTSANSLYRFLLDDQ CCCHHHHHHHHHCCC	10.11	23403867
334	Phosphorylation	NRHENRRYIPFLPGT CCCCCCCCCCCCCCC	15.09	23612710
347	Phosphorylation	GTGRDIDTGSIPGVD CCCCCCCCCCCCCHH	32.91	25072903
349	Phosphorylation	GRDIDTGSIPGVDQL CCCCCCCCCCCHHHH	27.92	23403867
380	Phosphorylation	GKRNRINTDDRKRSR CCCCCCCCCCCHHHC	36.58	-
388	Phosphorylation	DDRKRSRSVDSAFPF CCCHHHCCCCCCCCC	31.36	26657352
391	Phosphorylation	KRSRSVDSAFPFGLQ HHHCCCCCCCCCCCC	29.65	28857561
414	Phosphorylation	FSRNLGKSSEHLLRP HHHHCCCCCCHHCCH	38.88	24501219
415	Phosphorylation	SRNLGKSSEHLLRPS HHHCCCCCCHHCCHH	32.30	29449344
455	Phosphorylation	QGAAHGASCAHSRPP HHHHHCCCCCCCCCC	19.21	28857561
473	Phosphorylation	IDGKVLETEGSQEST CCCCEEEECCCCCCE	41.29	25072903
476	Phosphorylation	KVLETEGSQESTVIR CEEEECCCCCCEEEE	25.25	28857561
479	Phosphorylation	ETEGSQESTVIRAPS EECCCCCCEEEECCC	21.97	25072903
480	Phosphorylation	TEGSQESTVIRAPSL ECCCCCCEEEECCCC	21.14	25072903
486	Phosphorylation	STVIRAPSLGAQSKK CEEEECCCCCCCCCC	38.15	24670416
491	Phosphorylation	APSLGAQSKKEEEVK CCCCCCCCCCHHHHH	45.20	25072903
513	Phosphorylation	LQNRATATSPDSGAK HHCCCCCCCCCCCCC	36.12	25072903
514	Phosphorylation	QNRATATSPDSGAKK HCCCCCCCCCCCCCE	25.01	25072903
517	Phosphorylation	ATATSPDSGAKKISV CCCCCCCCCCCEEEE	43.99	25072903
520	Ubiquitination	TSPDSGAKKISVKTF CCCCCCCCEEEEEEC	54.91	22817900
521	Ubiquitination	SPDSGAKKISVKTFP CCCCCCCEEEEEECC	39.41	22817900
525 (in isoform 1)	Ubiquitination	-	37.34	21890473
525	Ubiquitination	GAKKISVKTFPSASN CCCEEEEEECCCCCC	37.34	21890473
526	Phosphorylation	AKKISVKTFPSASNT CCEEEEEECCCCCCC	38.33	29978859
529	Phosphorylation	ISVKTFPSASNTQAT EEEEECCCCCCCCCC	39.89	28857561
531	Phosphorylation	VKTFPSASNTQATPD EEECCCCCCCCCCHH	44.76	28857561
533	Phosphorylation	TFPSASNTQATPDLL ECCCCCCCCCCHHHH	19.65	29978859
536	Phosphorylation	SASNTQATPDLLKGQ CCCCCCCCHHHHHHH	13.91	29978859
547	Phosphorylation	LKGQQELTQQTNEET HHHHHHHHHHCCHHH	20.20	29978859
550	Phosphorylation	QQELTQQTNEETAKQ HHHHHHHCCHHHHHH	34.48	29978859
554	Phosphorylation	TQQTNEETAKQILYN HHHCCHHHHHHHHHH	32.73	29978859
567	Phosphorylation	YNYLKEGSTDNDDAT HHHHHHCCCCCCHHH	33.41	-
568	Phosphorylation	NYLKEGSTDNDDATK HHHHHCCCCCCHHHH	50.07	-
574	Phosphorylation	STDNDDATKRKVNLV CCCCCHHHHHHHHHH	38.07	-
681	Ubiquitination	ESEGELRKNLEELFQ HCHHHHHHHHHHHHH	77.75	21890473
681 (in isoform 1)	Ubiquitination	-	77.75	21890473
708	Phosphorylation	RDLQDQLSEMHDELD HHHHHHHHHHHHHHH	27.52	14702039
785	Phosphorylation	MDKLKEQYDAELQAL HHHHHHHHHHHHHHH	20.43	-
810	Phosphorylation	VEVLASRSNTSEQDQ HHHHHCCCCCCHHHH	41.80	29083192
812	Phosphorylation	VLASRSNTSEQDQAG HHHCCCCCCHHHHHH	34.58	29083192
813	Phosphorylation	LASRSNTSEQDQAGT HHCCCCCCHHHHHHH	37.19	29083192
865	Phosphorylation	DEAKAKETLKKYEGE CHHHHHHHHHHHHHH	43.07	-
921	Ubiquitination	EQKQLSEKLKEESEQ HHHHHHHHHHHHHHH	62.58	29967540
966	Phosphorylation	DIVEASRTSTLELQN HHHHHHHHHHHHHHH	24.46	-
967	Phosphorylation	IVEASRTSTLELQNQ HHHHHHHHHHHHHHH	29.86	-
1043	Ubiquitination	QLLEQTLKDLEYELE HHHHHHHHHHHHHHH	64.75	24816145
1052	Acetylation	LEYELEAKSHLKDDR HHHHHHHHHCCCHHH	29.09	20167786
1056	Ubiquitination	LEAKSHLKDDRSRLV HHHHHCCCHHHHHHH	52.76	24816145
1064	Acetylation	DDRSRLVKQMEDKVS HHHHHHHHHHHHHHH	48.82	20167786
1069	Acetylation	LVKQMEDKVSQLEME HHHHHHHHHHHHHHH	30.40	20167786
1121	Phosphorylation	DLECDKISLERQNKD HCCCCHHHHHHCCCC	29.89	23898821
1140	Phosphorylation	IIHLEGSYRSSKEGL EEEEECCCCCCCCCE	25.93	27642862
1196	Phosphorylation	QVDDEHLSLTDQKDQ HCCCCCCCCCCHHHH	31.00	26074081
1198	Phosphorylation	DDEHLSLTDQKDQLS CCCCCCCCCHHHHHH	32.77	26074081
1205	Phosphorylation	TDQKDQLSLRLKAMK CCHHHHHHHHHHHHH	13.05	24719451
1227	Phosphorylation	EEIDRLESSKKKLQR HHHHHHHHHHHHHHH	52.64	-
1264	Phosphorylation	LRLKKLPSKVLDDMD HHHHCCCHHHCCCCC	45.92	24719451
1277	Phosphorylation	MDDDDDLSTDGGSLY CCCCCCCCCCCCCEE	31.29	28857561
1278	Phosphorylation	DDDDDLSTDGGSLYE CCCCCCCCCCCCEEE	46.06	28857561
1282	Phosphorylation	DLSTDGGSLYEAPVS CCCCCCCCEEECCEE	33.05	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CGNL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CGNL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CGNL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF7_HUMAN	TRAF7	physical	28514442
NDE1_HUMAN	NDE1	physical	28514442
HMMR_HUMAN	HMMR	physical	28514442
GRAP1_HUMAN	GRIPAP1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 139300: Aromatase excess syndrome (AEXS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.