dbPTM

CDPK6_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CDPK6_ARATH
UniProt AC	Q38872
Protein Name	Calcium-dependent protein kinase 6
Gene Name	CPK6
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	544
Subcellular Localization	Cell membrane Lipid-anchor . Nucleus .
Protein Description	May play a role in signal transduction pathways that involve calcium as a second messenger. Functions in abscisic acid (ABA) regulation of guard cell S-type anion-and Ca(2+)-permeable channels and stomatal closure. [PubMed: 17032064 Phosphorylates FD]
Protein Sequence	MGNSCRGSFKDKIYEGNHSRPEENSKSTTTTVSSVHSPTTDQDFSKQNTNPALVIPVKEPIMRRNVDNQSYYVLGHKTPNIRDLYTLSRKLGQGQFGTTYLCTDIATGVDYACKSISKRKLISKEDVEDVRREIQIMHHLAGHKNIVTIKGAYEDPLYVHIVMELCAGGELFDRIIHRGHYSERKAAELTKIIVGVVEACHSLGVMHRDLKPENFLLVNKDDDFSLKAIDFGLSVFFKPGQIFKDVVGSPYYVAPEVLLKHYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGYIDFDTDPWPVISDSAKDLIRKMLCSSPSERLTAHEVLRHPWICENGVAPDRALDPAVLSRLKQFSAMNKLKKMALKVIAESLSEEEIAGLRAMFEAMDTDNSGAITFDELKAGLRRYGSTLKDTEIRDLMEAADVDNSGTIDYSEFIAATIHLNKLEREEHLVSAFQYFDKDGSGYITIDELQQSCIEHGMTDVFLEDIIKEVDQDNDGRIDYEEFVAMMQKGNAGVGRRTMKNSLNISMRDV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-myristoyl glycine	------MGNSCRGSF ------CCCCCCCHH	34.46	-
2	Myristoylation	------MGNSCRGSF ------CCCCCCCHH	34.46	19029837
29	Phosphorylation	EENSKSTTTTVSSVH CCCCCCCEEEEEECC	27.79	30589143
30	Phosphorylation	ENSKSTTTTVSSVHS CCCCCCEEEEEECCC	25.86	25561503
31	Phosphorylation	NSKSTTTTVSSVHSP CCCCCEEEEEECCCC	19.12	25561503
33	Phosphorylation	KSTTTTVSSVHSPTT CCCEEEEEECCCCCC	25.26	27532006
34	Phosphorylation	STTTTVSSVHSPTTD CCEEEEEECCCCCCC	21.36	27532006
37	Phosphorylation	TTVSSVHSPTTDQDF EEEEECCCCCCCCCH	23.06	17317660
39	Phosphorylation	VSSVHSPTTDQDFSK EEECCCCCCCCCHHH	46.12	25561503
40	Phosphorylation	SSVHSPTTDQDFSKQ EECCCCCCCCCHHHC	34.74	25561503
49	Phosphorylation	QDFSKQNTNPALVIP CCHHHCCCCCCEEEE	39.83	23111157
249	Phosphorylation	IFKDVVGSPYYVAPE CHHHCCCCCCEECHH	9.71	-
532	Phosphorylation	NAGVGRRTMKNSLNI CCCCCHHHHCHHCCC	31.01	25561503
536	Phosphorylation	GRRTMKNSLNISMRD CHHHHCHHCCCCCCC	19.78	30291188
540	Phosphorylation	MKNSLNISMRDV--- HCHHCCCCCCCC---	13.49	30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CDPK6_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CDPK6_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CDPK6_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
FD_ARATH	FD	physical	25661797

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CDPK6_ARATH

Related Literatures of Post-Translational Modification

Myristoylation
Reference	PubMed
"Experimental testing of predicted myristoylation targets involved inasymmetric cell division and calcium-dependent signalling."; Benetka W., Mehlmer N., Maurer-Stroh S., Sammer M., Koranda M.,Neumueller R., Betschinger J., Knoblich J.A., Teige M., Eisenhaber F.; Cell Cycle 7:3709-3719(2008). Cited for: MYRISTOYLATION, AND SUBCELLULAR LOCATION.	19029837 [Abstract]
Phosphorylation
Reference	PubMed
"Phosphoproteomic analysis of nuclei-enriched fractions fromArabidopsis thaliana."; Jones A.M.E., MacLean D., Studholme D.J., Serna-Sanz A.,Andreasson E., Rathjen J.P., Peck S.C.; J. Proteomics 72:439-451(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-540, AND MASSSPECTROMETRY.	19245862 [Abstract]
"Site-specific phosphorylation profiling of Arabidopsis proteins bymass spectrometry and peptide chip analysis."; de la Fuente van Bentem S., Anrather D., Dohnal I., Roitinger E.,Csaszar E., Joore J., Buijnink J., Carreri A., Forzani C.,Lorkovic Z.J., Barta A., Lecourieux D., Verhounig A., Jonak C.,Hirt H.; J. Proteome Res. 7:2458-2470(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-536, AND MASSSPECTROMETRY.	18433157 [Abstract]