CASPC_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CASPC_MOUSE
• UniProt AC: O08736
• Protein Name: Caspase-12
• Gene Name: Casp12
• Organism: Mus musculus (Mouse).
• Sequence Length: 419
• Protein Description: Involved in the activation cascade of caspases responsible for apoptosis execution..
• Protein Sequence: MAARRTHERDPIYKIKGLAKDMLDGVFDDLVEKNVLNGDELLKIGESASFILNKAENLVENFLEKTDMAGKIFAGHIANSQEQLSLQFSNDEDDGPQKICTPSSPSESKRKVEDDEMEVNAGLAHESHLMLTAPHGLQSSEVQDTLKLCPRDQFCKIKTERAKEIYPVMEKEGRTRLALIICNKKFDYLFDRDNADTDILNMQELLENLGYSVVLKENLTAQEMETELMQFAGRPEHQSSDSTFLVFMSHGILEGICGVKHRNKKPDVLHDDTIFKIFNNSNCRSLRNKPKILIMQACRGRYNGTIWVSTNKGIATADTDEERVLSCKWNNSITKAHVETDFIAFKSSTPHNISWKVGKTGSLFISKLIDCFKKYCWCYHLEEIFRKVQHSFEVPGELTQMPTIERVSMTRYFYLFPGN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	THERDPIYKIKGLAK CCCCCCCHHCHHHHH	16.43	29514104
49	Phosphorylation	LKIGESASFILNKAE EECCHHHHHHHHHHH	23.31	27180971
80	Phosphorylation	FAGHIANSQEQLSLQ HHHHCCCCCCCEEEE	26.52	25619855
85	Phosphorylation	ANSQEQLSLQFSNDE CCCCCCEEEEECCCC	21.59	-
89	Phosphorylation	EQLSLQFSNDEDDGP CCEEEEECCCCCCCC	30.34	25619855
101	Phosphorylation	DGPQKICTPSSPSES CCCCEEECCCCCCHH	29.67	29233185
103	Phosphorylation	PQKICTPSSPSESKR CCEEECCCCCCHHHC	36.41	26060331
104	Phosphorylation	QKICTPSSPSESKRK CEEECCCCCCHHHCC	33.38	26824392
106	Phosphorylation	ICTPSSPSESKRKVE EECCCCCCHHHCCCC	57.35	26824392
108	Phosphorylation	TPSSPSESKRKVEDD CCCCCCHHHCCCCCC	41.94	26060331
332	Phosphorylation	LSCKWNNSITKAHVE HCCEECCCCEEEEEE	28.55	24719451
408	Phosphorylation	MPTIERVSMTRYFYL CCCEEEEEEEEEEEE	22.21	-
412	Phosphorylation	ERVSMTRYFYLFPGN EEEEEEEEEEECCCC	6.34	-
414	Phosphorylation	VSMTRYFYLFPGN-- EEEEEEEEECCCC--	9.86	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CASPC_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CASPC_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CASPC_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TERA_MOUSE	Vcp	physical	14561754
PDCD6_MOUSE	Pdcd6	physical	14561754

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.